Key Highlights

Risk & Performance

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

18.9%

7 terminated/withdrawn out of 37 trials

Success Rate

79.4%

-7.1% vs industry average

Late-Stage Pipeline

14%

5 trials in Phase 3/4

Results Transparency

44%

12 of 27 completed trials have results

Key Signals

2 recruiting12 with results

Enrollment Performance

Analytics

Phase 1

10(45.5%)

Phase 4

4(18.2%)

N/A

3(13.6%)

Early Phase 1

2(9.1%)

Phase 2

2(9.1%)

Phase 3

1(4.5%)

22Total

Phase 1(10)

Phase 4(4)

N/A(3)

Early Phase 1(2)

+2 more

Activity Timeline

Global Presence

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Clinical Trials (37)

Showing 20 of 37 trials

NCT07293559Recruiting

Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

Role: lead

NCT07207876Recruiting

Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

Role: lead

NCT05154513Completed

Long-Term Clinical, Immunologic, and Virologic Profiles of Children Who Received Early Treatment for HIV

Role: lead

NCT04518228Completed

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

Role: collaborator

NCT05539989Phase 1Withdrawn

Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa

Role: lead

NCT04024488Not ApplicableActive Not Recruiting

Group-Based Intervention to Improve Mental Health and Adherence Among Youth Living With HIV in Low Resource Settings

Role: lead

NCT00955968Phase 4Completed

IMPAACT 1077HS: Examining Benefits of HAART Continuation in Postpartum Women

Role: lead

NCT03760458Phase 1Completed

The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less Than 12 Years of Age

Role: collaborator

NCT02140944Completed

IMPAACT P1107: Effects of Cord Blood Transplantation With CCR5Δ32 Donor Cells on HIV Persistence

Role: lead

NCT00672412Phase 1Completed

Safety and Pharmacokinetic Study of Fixed Dose Combination of Zidovudine, Lamivudine, and Nevirapine in HIV-Infected Children in Thailand

Role: collaborator

NCT00006604Phase 1Completed

Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents

Role: collaborator

NCT00459316Phase 1Completed

Safety of and Immune Response to a Meningitis Vaccine in HIV-Infected Children and Youth

Role: collaborator

NCT00312091Phase 1Completed

Drug Levels of Tablet and Liquid Forms of Lamivudine, Nevirapine, and Stavudine in HIV Infected Thai Children

Role: collaborator

NCT00614640Phase 1Withdrawn

Safety and Tolerability of a Therapeutic DNA Dendritic Cell Vaccine in HIV-Infected Children, Adolescents, and Young Adults

Role: collaborator

NCT00076791Phase 1Completed

Safety of Tenofovir Disoproxil Fumarate (TDF) and Emtricitabine/TDF in HIV Infected Pregnant Women and Their Infants

Role: collaborator

NCT01818258Phase 4Completed

IMPAACT P1092: Steady State PK in Malnourished HIV Infected Children

Role: lead

NCT02383849Completed

IMPAACT P1106: Pharmacokinetic Characteristics of Antiretrovirals and Tuberculosis Medicines in Low Birth Weight Infants

Role: lead

NCT01232361Completed

IMPAACT P1080: Psychiatric and Antiretroviral Medication Concentrations in HIV-infected and Uninfected Children and Adolescents

Role: lead

NCT02939131Not ApplicableCompleted

IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV

Role: lead

NCT03416790Completed

IMPAACT 2015 - Evaluation of the HIV-1 Reservoir in the Central Nervous System of Perinatally-Infected Youth and Young Adults With Cognitive Impairment

Role: lead