The Effects of Smell on Mood and Physical Responses
Psychoneuroimmunology and Mind-Body Medicine: Olfaction, Mood, and Physiological Responses
1 other identifier
interventional
56
1 country
1
Brief Summary
The purpose of this study is to examine the body's response to relaxing and stimulating fragrances commonly used in aromatherapy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1
Started Aug 2005
Shorter than P25 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 19, 2004
CompletedFirst Posted
Study publicly available on registry
November 22, 2004
CompletedStudy Start
First participant enrolled
August 1, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2006
CompletedResults Posted
Study results publicly available
February 4, 2010
CompletedFebruary 18, 2010
February 1, 2010
7 months
November 19, 2004
April 23, 2009
February 12, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Cortisol and Catecholamine Production
Cortisol, norepinephrine, epinephrine measured before and after physical (cold pressor) stressor, which occurred at 11:00.
3 Visits with at least 2 weeks between each. Average time to complete all visits was 64.46 days (SD 48.4). Cortisol: 9:05, 10:05, 10:55, 11:45, 12:15, 13:00. Nor/Epi: 9:05, 10:05, 10:55, 11:05, 11:45, 12:15
Immune Function
Stimulated Cytokine Production (Interleukin-6 (IL-6), Interleukin-10 (IL-10)) measured before and after cold pressor stressor, which occurred at 11:00.
3 Visits with at least 2 weeks between each. Average time to complete all visits was 64.46 days (SD 48.4). 9:05, 10:05, 11:45
Skin Barrier Repair
TEWL (Transepidermal Water Loss, via tape stripping procedure)measured before and after cold pressor stressor (11:00). After obtaining baseline measurements on volar forearm, cellophane tape(3M Scotch-type; St. Paul, MN) was applied repeatedly (6-50 times) to remove superficial layer of cornified skin cells. Tape stripping stopped when TEWL was elevated from the basal level of 5-7 g/h/m2 to at least 20 g/h/m2. The number of strips required to reach TEWL X20 g/m2/h was the measure of barrier. TEWL was measured with a computerized evaporimetry instrument, the DermaLabs (CyberDERM, Media, PA).
3 Visits with at least 2 weeks between each. Average time to complete all visits was 64.46 days (SD 48.4).10:05, 11:45, 13:15
Immune Function: Delayed Hypersensitivity to Candida(DTH)
DTH memory responses to a common infectious agent provided a measure of T-cell immunity. Nurses inoculated subject's arm with 0.1ml Candida (stock solution diluted 1:20 in saline, Greer Labs, NC) intradermally, after the cold pressor stressor. The wheal diameter (2 dimensions) was self-assessed at 24, 48, and 72 hours by participants given detailed instructions and templates for measurement.
Day 1 11:45, Day 2 (24h) 11:45, Day 3 (48h) 11:45, Day 4 (72h) 11:45.
Study Arms (3)
Lavender
EXPERIMENTALCitrus
EXPERIMENTALWater
PLACEBO COMPARATORInterventions
A yellow-tinted cotton ball containing 100 ml of the essential oil or distilled water was taped between the nose and upper lip on top of a piece of surgical tape; use of the barrier tape avoided percutaneous absorption . This method provided continuous and uniform exposure across subjects that would not have been possible with ambient room inhalation, and helped maintain experimenter blindness.
Eligibility Criteria
You may qualify if:
- Healthy adults with a normal sense of smell
You may not qualify if:
- Treatment with medication that has immunological or endocrinological consequences
- Chronic health problems that affect immune or endocrine systems
- Allergy to perfume or cosmetics
- Problems with sense of smell
- Respiratory problems
- Smoker
- Current active asthma
- Use of psychoactive drugs or mood-altering medication
- History of anxiety disorder, major depression, bipolar disorder, schizophrenia, or other psychotic disorders
- History of chest pain or ventricular fibrillation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ohio State University Institute for Biobehavioral Medicine Research
Columbus, Ohio, 43210, United States
Related Publications (1)
Kiecolt-Glaser JK, Graham JE, Malarkey WB, Porter K, Lemeshow S, Glaser R. Olfactory influences on mood and autonomic, endocrine, and immune function. Psychoneuroendocrinology. 2008 Apr;33(3):328-39. doi: 10.1016/j.psyneuen.2007.11.015.
PMID: 18178322RESULT
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Janice K. Kiecolt-Glaser, PhD
- Organization
- The Ohio State University, Department of Psychiatry
Study Officials
- PRINCIPAL INVESTIGATOR
Janice Kiecolt-Glaser, PhD
Ohio State University Institute for Biobehavioral Medicine Research
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- NIH
Study Record Dates
First Submitted
November 19, 2004
First Posted
November 22, 2004
Study Start
August 1, 2005
Primary Completion
March 1, 2006
Study Completion
March 1, 2006
Last Updated
February 18, 2010
Results First Posted
February 4, 2010
Record last verified: 2010-02