NCT00078611

Brief Summary

The purpose of this trial is to evaluate natalizumab in individuals with moderately to severely active Crohn's Disease.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
462

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Mar 2004

Shorter than P25 for phase_3

Geographic Reach
2 countries

75 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 1, 2004

Completed
Same day until next milestone

Study Start

First participant enrolled

March 1, 2004

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 8, 2004

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2005

Completed
Last Updated

June 16, 2016

Status Verified

March 1, 2012

Enrollment Period

1 year

First QC Date

March 1, 2004

Last Update Submit

June 14, 2016

Conditions

Keywords

Crohn's diseaseInflammatory Bowel DiseaseIBDGastroenterologyRegional EnteritisColitis

Interventions

Also known as: Antegren

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
* Males and females 18 years of age or older * Diagnosis of Crohn's disease for at least 6 months * Females must not be pregnant or breastfeeding * Must not have previously taken natalizumab * Use of some other Crohn's disease medications is permitted, but will be closely supervised

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (75)

Harmony Clinical Research

Oro Valley, Arizona, 85739, United States

Location

Advanced Clinical Therapeutics

Tucson, Arizona, 85712, United States

Location

Advanced Clinical Research Institute

Anaheim, California, 92801, United States

Location

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

Location

Digestive Diseases Foundation

Los Angeles, California, 90067, United States

Location

David Geffen School of Medicine at UCLA, Division of Digestive Diseases

Los Angeles, California, 90092-7019, United States

Location

Community Clinical Trials

Orange, California, 92868, United States

Location

UCSF / Mt. Zion IBD Center

San Francisco, California, 94115, United States

Location

Shared Medical Research Foundation

Tarzana, California, 91356, United States

Location

Lynn Institute of the Rockies

Colorado Springs, Colorado, 80909, United States

Location

Rocky Mountain Gastroenterology

Golden, Colorado, 80215, United States

Location

Arapahoe Gastroenterology

Littleton, Colorado, 80120, United States

Location

Center for Medical Research, LLC

Manchester, Connecticut, 06040, United States

Location

Morowitz, Marion, Laessing, Shocket, Bashir, Steinberg, Salcedo

Washington D.C., District of Columbia, 20010, United States

Location

Malcolm Randall VA Medical Center

Gainesville, Florida, 32608, United States

Location

Borland Groover Clinic

Jacksonville, Florida, 32256, United States

Location

Miami Research Associates, Inc.

Miami, Florida, 33173, United States

Location

Waterside Clinical Research Services, Inc.

West Palm Beach, Florida, 33407, United States

Location

Shafran Gastroenterology Center

Winterpark, Florida, 32789, United States

Location

Atlanta Gastroenterology Associates

Atlanta, Georgia, 30342, United States

Location

University of Chicago Hospitals

Chicago, Illinois, 60637, United States

Location

Outpatient Clinical Research Facility

Indianapolis, Indiana, 46202-5250, United States

Location

Indianapolis Gastroenterology Research Foundation

Indianapolis, Indiana, 46227, United States

Location

University of Kentucky Medical Center

Lexington, Kentucky, 40536, United States

Location

University of Louisville

Louisville, Kentucky, 40202, United States

Location

Drug Research Service, Inc.

Metairie, Louisiana, 70001, United States

Location

Metropolitan Gastroenterology Group, PC / Chevy Chase Clinical Research

Chevy Chase, Maryland, 20815, United States

Location

Minnesota Gastroenterology, P.A.

Plymouth, Minnesota, 55446, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Long Island Clinical Research Associates, LLP

Great Neck, New York, 11021, United States

Location

New York Center for Clinical Research

Lake Success, New York, 11042, United States

Location

Mount Sinai School of Medicine

New York, New York, 10028, United States

Location

Rochester Institute for Digestive Diseases and Sciences, Inc.

Rochester, New York, 14607, United States

Location

Asheville Gastroenterology Associates

Asheville, North Carolina, 28801, United States

Location

University of North Carolina

Chapel Hill, North Carolina, 27599, United States

Location

Charlotte Gastroenterology & Hepatology, PLLC.

Charlotte, North Carolina, 28207, United States

Location

Wake Research Associates

Raleigh, North Carolina, 27612, United States

Location

Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27012, United States

Location

Consultants for Clinical Research, Inc.

Cincinnati, Ohio, 45219, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Oklahoma Foundation for Digestive Research

Oklahoma City, Oklahoma, 73104, United States

Location

Lynn Health Science Institute

Oklahoma City, Oklahoma, 73112, United States

Location

Oklahoma Gastroenterology Associates

Tulsa, Oklahoma, 74104, United States

Location

Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States

Location

Allegheny Center for Digestive Health

Pittsburgh, Pennsylvania, 15212, United States

Location

Gastroenterology Associates

Providence, Rhode Island, 02904, United States

Location

Medical University of South Carolina - Digestive Disease Center

Charleston, South Carolina, 29425, United States

Location

Southeastern Clinical Research

Chattanooga, Tennessee, 37403, United States

Location

Gastroenterology Center of the Midsouth, P.C.

Memphis, Tennessee, 38120, United States

Location

Summit Research Solutions

Memphis, Tennessee, 38120, United States

Location

Nashville Medical Research Institute

Nashville, Tennessee, 37205, United States

Location

Austin Gastroenterology, PA

Austin, Texas, 78745, United States

Location

Atilla Ertan, MD, PA

Houston, Texas, 77030, United States

Location

Gastroenterology Clinic of San Antonio, P.A.

San Antonio, Texas, 78229, United States

Location

Wasatch Clinical Research

Salt Lake City, Utah, 84107, United States

Location

UVA Health System

Charlottesville, Virginia, 22908, United States

Location

Gastroenterology Associates of Tidewater

Chesapeake, Virginia, 23320, United States

Location

Internal Medicine Associates

Danville, Virginia, 24541, United States

Location

McGuire DVAMC GI (111N)

Richmond, Virginia, 23249, United States

Location

Virginia Mason Medical Center

Seattle, Washington, 98101, United States

Location

Tacoma Digestive Disease Research Center

Tacoma, Washington, 98405, United States

Location

Aurora Helath Care

Milwaukee, Wisconsin, 53215, United States

Location

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

University of Calgary

Calgary, Alberta, T2N 4N1, Canada

Location

GI Research

Edmonton, Alberta, T5H 4B9, Canada

Location

University of Alberta

Edmonton, Alberta, T6G 2C8, Canada

Location

Liver and Intestinal Research Centre

Vancouver, British Columbia, V5Z 1H2, Canada

Location

St. Paul's Hospital

Vancouver, British Columbia, V6Z 1Y6, Canada

Location

Health Sciences Center

Winnipeg, Manitoba, R3A 1R9, Canada

Location

Queen Elizabeth II Science Center

Halifax, Nova Scotia, B3H 1V7, Canada

Location

McMaster University Medical Centre

Hamilton, Ontario, L8N 3Z5, Canada

Location

Sunnybrook & Women's College Health Sciences Center

Toronto, Ontario, M4N 3M5, Canada

Location

Mount Sinai Hospital

Toronto, Ontario, M5G 1X5, Canada

Location

Montreal General Hospital

Montreal, Quebec, H3G 1A4, Canada

Location

Chauq Hopital Du St. Sacrement

Québec, Quebec, G1S 4L8, Canada

Location

MeSH Terms

Conditions

Crohn DiseaseInflammatory Bowel DiseasesColitis

Interventions

Natalizumab

Condition Hierarchy (Ancestors)

GastroenteritisGastrointestinal DiseasesDigestive System DiseasesIntestinal DiseasesColonic Diseases

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, HumanizedAntibodies, MonoclonalAntibodiesImmunoglobulinsImmunoproteinsBlood ProteinsProteinsAmino Acids, Peptides, and ProteinsSerum GlobulinsGlobulins

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 1, 2004

First Posted

March 8, 2004

Study Start

March 1, 2004

Primary Completion

March 1, 2005

Study Completion

March 1, 2005

Last Updated

June 16, 2016

Record last verified: 2012-03

Locations