Combination Chemotherapy and Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer

NCT00073866 | Completed Phase 1 DMC

• 3 other identifiers: NU 01L2NU-01L2PHARMACIA-NU-01L2
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 3

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib may stop the growth of tumor cells by stopping blood flow to the tumor. Combining celecoxib with combination chemotherapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of irinotecan and docetaxel when given together with celecoxib and to see how well they work in treating patients with advanced non-small cell lung cancer.

Conditions

Lung Cancer

Keywords

recurrent non-small cell lung cancer; stage IIIB non-small cell lung cancer; stage IV non-small cell lung cancer

Interventions

celecoxib DRUG

docetaxel DRUG

irinotecan hydrochloride DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Diagnosis of non-small cell lung cancer (NSCLC) meeting 1 of the following criteria: * Stage IV * Stage IIIB with a malignant pleural effusion * Locally recurrent and/or persistent disease after locoregional therapy with or without systemic chemotherapy * Unidimensionally measurable disease * If the only site of measurable disease is in a previously irradiated area must have documented progression of disease in that area * No CNS metastases PATIENT CHARACTERISTICS: Age * 18 and over Performance status * ECOG 0-2 Life expectancy * Not specified Hematopoietic * Absolute neutrophil count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic * Bilirubin normal * AST and ALT less than 2.5 times upper limit of normal (ULN) (if alkaline phosphatase is normal) * Alkaline phosphatase less than 4 times ULN (if AST and ALT are normal) Renal * Creatinine less than 2.0 mg/dL Other * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception during and for 3 months after study treatment * No other malignancy within the past 5 years except curatively treated squamous cell or basal cell skin cancer or carcinoma in situ of the cervix * No diagnosis of peptic ulcer disease or gastritis/esophagitis within the past 60 days * No prior hypersensitivity to cyclooxygenase-2 (COX-2) inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, sulfonamides, or drugs formulated with polysorbate 80 * No pre-existing grade 2 or greater peripheral neuropathy * No concurrent medical condition that would preclude study compliance PRIOR CONCURRENT THERAPY: Biologic therapy * At least 1 week since prior biologic therapy * Phase I patients: * Any number of prior biologic therapies allowed (e.g., chimeric antibodies or kinase inhibitors) * Phase II patients: * No prior biologic therapy for recurrent/metastatic disease * No concurrent filgrastim (G-CSF) Chemotherapy * See Disease Characteristics * At least 4 weeks since prior chemotherapy * No prior irinotecan or docetaxel * Phase I patients: * Up to 2 prior chemotherapy regimens for recurrent/metastatic disease allowed (chemonaïve patients are also eligible) * Phase II patients: * At least 1 year since prior adjuvant or neoadjuvant chemotherapy for stage I-IIIA disease * No prior chemotherapy for recurrent/metastatic disease Endocrine therapy * Less than 2 weeks of cumulative oral/IV corticosteroid use within the past 3 months Radiotherapy * See Disease Characteristics * Recovered from prior radiotherapy * At least 3 weeks since prior extensive-field radiotherapy for recurrent/metastatic disease Surgery * Recovered from prior surgery Other * More than 60 days since prior treatment for peptic ulcer disease or gastritis/esophagitis * No prior NSAIDs at a frequency of more than 3 times per week for a cumulative period of more than 2 weeks within the past 30 days * No concurrent antiepileptics, cyclosporine, aspirin, or fluconazole * No concurrent NSAIDs * No other concurrent COX-2 inhibitors

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Northwestern University: lead
• National Cancer Institute (NCI): collaborator

Study Sites (3)

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Chicago, Illinois, 60611-3013, United States

Location

Evanston Northwestern Health Care - Evanston Hospital

Evanston, Illinois, 60201, United States

Location

Silver Cross Hospital

Joliet, Illinois, 60432, United States

Location

Related Publications (1)

• Argiris A, Kut V, Luong L, Avram MJ. Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer. Invest New Drugs. 2006 May;24(3):203-12. doi: 10.1007/s10637-005-3259-4.

  PMID: 16096702 RESULT

MeSH Terms

Conditions

Lung Neoplasms; Carcinoma, Non-Small-Cell Lung

Interventions

Celecoxib; Docetaxel; Irinotecan

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms

Intervention Hierarchy (Ancestors)

Benzenesulfonamides; Sulfonamides; Amides; Organic Chemicals; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Sulfones; Sulfur Compounds; Pyrazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Taxoids; Cyclodecanes; Cycloparaffins; Hydrocarbons, Alicyclic; Diterpenes; Terpenes; Camptothecin; Alkaloids

Study Officials

• Athanassios Argiris, MD

  Robert H. Lurie Cancer Center

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 1
• Purpose: TREATMENT
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 10, 2003
• First Posted: December 11, 2003
• Study Start: June 1, 2003
• Primary Completion: December 1, 2004
• Study Completion: December 1, 2004
• Last Updated: July 19, 2012

Record last verified: 2012-07

Locations

US (3)