NCT00072917

Brief Summary

This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Oct 2003

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2003

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

November 12, 2003

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 14, 2003

Completed
4.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

January 18, 2010

Status Verified

January 1, 2010

First QC Date

November 12, 2003

Last Update Submit

January 15, 2010

Conditions

ObesityThinnessWeight Gain

Keywords

obesitythinnessweight gainphysical activitydietfat oxidationhungerfeeding behavioroverfeeding

Eligibility Criteria

Age25 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Subjects have been recruited through advertisements in local news media and on the internet

* Half of the subjects will be women, half will be men, * age 25-35, * a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI\>30. * Subjects should not engage in planned physical activity more than 3 hrs per week. * For the obesity prone group there should be at least 1 1st degree relative with a BMI\>30.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

University of Colorado Health Sciences Center

Denver, Colorado, 80262, United States

Location

Related Publications (2)

  • Rynders CA, Pereira RI, Bergouignan A, Kealey EH, Bessesen DH. Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity-Prone and Resistant Adults. Obesity (Silver Spring). 2018 Nov;26(11):1758-1766. doi: 10.1002/oby.22321.

    PMID: 30358145DERIVED

  • Creasy SA, Rynders CA, Bergouignan A, Kealey EH, Bessesen DH. Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring). 2018 Apr;26(4):696-702. doi: 10.1002/oby.22121.

    PMID: 29570248DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood and urine

MeSH Terms

Conditions

ObesityThinnessWeight GainMotor ActivityFeeding Behavior

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBody Weight ChangesBehaviorBehavior, Animal

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
NIH

Study Record Dates

First Submitted

November 12, 2003

First Posted

November 14, 2003

Study Start

October 1, 2003

Study Completion

June 1, 2008

Last Updated

January 18, 2010

Record last verified: 2010-01

Locations

US(1)