NCT00069589

Brief Summary

Alopecia areata is the loss of hair in patches that can proceed to loss of all hair (alopecia totalis or universalis). The purpose of the registry is to collect patient information and blood samples from people with alopecia areata.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,100

participants targeted

Target at P75+ for all trials

Timeline
895mo left

Started Nov 2001

Longer than P75 for all trials

Geographic Reach
1 country

5 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress25%
Nov 2001Nov 2099

Study Start

First participant enrolled

November 1, 2001

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

September 29, 2003

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 30, 2003

Completed
96.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2099

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2099

Last Updated

May 14, 2019

Status Verified

May 1, 2019

Enrollment Period

98.1 years

First QC Date

September 29, 2003

Last Update Submit

May 13, 2019

Conditions

Alopecia AreataAlopecia TotalisAlopecia UniversalisAutoimmune Hair LossAlopecia Partialis

Keywords

BaldnessAutoimmunityHairAlopecia AreataAlopecia PartialisAlopecia TotalisAlopecia UniversalisAutoimmune Hair Loss

Outcome Measures

Primary Outcomes (1)

  • Alopecia Areata Registry

    Database registration of participants via collection of participant epidemiology data.

    Registration on-going

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with alopecia areata (AA), both children and adults, who have been diagnosed by a physician with alopecia universalis, alopecia totalis, patchy persistent AA, or transient mild AA. Family members (related by blood) of these patients, preferably sib-pairs plus parents and multiplex families(persons with at least three family members with AA or alopecia universalis and alopecia totalis). Also, healthy individuals who are unaffected, non-blood related individuals and do not live in the same household with alopecia areata patient are needed as controls.

You may qualify if:

  • Diagnosed with alopecia areata by a dermatologist
  • United States resident
  • Accepts Health Volunteers: Non blood-related individuals who are unaffected with alopecia areata and do not live in the same household with alopecia areata patient.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

University of California, San Francisco

San Francisco, California, 94143, United States

Location

University of Colorado - UCHSC - Health Science Center at Fitzsimons

Aurora, Colorado, 80010-7163, United States

Location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Columbia University

New York, New York, 10032, United States

Location

M.D. Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Publications (9)

  • Duvic M, Norris D, Christiano A, Hordinsky M, Price V. Alopecia areata registry: an overview. J Investig Dermatol Symp Proc. 2003 Oct;8(2):219-21. doi: 10.1046/j.1087-0024.2003.00814.x.

    PMID: 14582678RESULT

  • Barahmani N, Yang Y, Lopez A, Duvic M. Atopic alopecia areata patients have increased serum Th1 Cytokine profiles. 66th Annual meeting of Society for Investigative Dermatology. St.Louis, MO, May 2005. JID 124 (4): A100, 2005.

    RESULT

  • Breuer-McHam J, Hunzicker K, Barahmani N, Zhang Q, Babu D, Christiano A, Hordinsky M, Norris D, Price V, Duvic, M. Epidemiologic and disease associations in participants of the national alopecia areata (NAAR) registrants. Accepted by Society for Investigational Dermatology, April 12, 2004. JID 122 (3): A107, 2004.

    RESULT

  • de Andrade M, Barahmani N, Hunzicker K, Zhang Q, Joan Breuer- McHam, Joyce Osei, Daniel Babu, Qingyi Wei, Reveille J, Duvic M. HLA Class II associations confirm alopecia areata phenotypic subsets. 66th Annual meeting of Society for Investigative Dermatology. St. Louis, MO, May 2005.JID 124 (4): A107, 2005.

    RESULT

  • Barahmani N, de Andrade M, Slusser JP, Wei Q, Hordinsky M, Price VH, Christiano A, Norris D, Reveille J, Duvic M. Human leukocyte antigen class II alleles are associated with risk of alopecia areata. J Invest Dermatol. 2008 Jan;128(1):240-3. doi: 10.1038/sj.jid.5700973. Epub 2007 Jul 19. No abstract available.

    PMID: 17637820RESULT

  • Ahmed AM, Barahmani N, Duvic M; National Alopecia Areata Registry. Familial alopecia areata and chronic thrombocytopenia. J Am Acad Dermatol. 2008 May;58(5 Suppl 1):S75-7. doi: 10.1016/j.jaad.2007.05.017.

    PMID: 18489053RESULT

  • Rodriguez TA, Duvic M; National Alopecia Areata Registry. Onset of alopecia areata after Epstein-Barr virus infectious mononucleosis. J Am Acad Dermatol. 2008 Jul;59(1):137-9. doi: 10.1016/j.jaad.2008.02.005. Epub 2008 Mar 7.

    PMID: 18329131RESULT

  • Martinez-Mir A, Zlotogorski A, Gordon D, Petukhova L, Mo J, Gilliam TC, Londono D, Haynes C, Ott J, Hordinsky M, Nanova K, Norris D, Price V, Duvic M, Christiano AM. Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet. 2007 Feb;80(2):316-28. doi: 10.1086/511442. Epub 2007 Jan 5.

    PMID: 17236136RESULT

  • Barahmani N, de Andrade M, Slusser JP, Zhang Q, Duvic M. Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata. J Invest Dermatol. 2006 Jan;126(1):74-8. doi: 10.1038/sj.jid.5700009.

    PMID: 16417220RESULT

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

DNA will be analyzed to learn the link between gene markers of traites of alopecia areata. Sera will be used to analyse cytokins. Lymphocytes will be used for the creation of B-cell lines.

MeSH Terms

Conditions

Alopecia AreataAlopecia universalisAlopeciaAutoimmune Diseases

Condition Hierarchy (Ancestors)

HypotrichosisHair DiseasesSkin DiseasesSkin and Connective Tissue DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsImmune System Diseases

Study Officials

  • Madeleine Duvic, MD

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 29, 2003

First Posted

September 30, 2003

Study Start

November 1, 2001

Primary Completion (Estimated)

November 1, 2099

Study Completion (Estimated)

November 1, 2099

Last Updated

May 14, 2019

Record last verified: 2019-05

Locations

US(5)