A Trial of Tap Water Treatment in the Elderly

NCT00058942 | Completed

• 2 other identifiers: AG00025R01AG016634-03
• Study Type: interventional
• Target: 810
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being conducted in Sonoma County, California. Gastrointestinal illness and diarrhea are recognized as a significant cause of morbidity and mortality in the elderly. One study showed that 51% of deaths caused by diarrhea over a 9-year period occurred in individuals over the age of 74 years. Although many infectious diseases are more problematic in the elderly because of a decline in immune function and a higher incidence of pre-existing malnutrition and dehydration, it is still not known what the principal modes of transmission are and which infectious agents are responsible. The principal objective of this study is to evaluate the ability of in-home treatment of tapwater to reduce gastrointestinal illness in non-institutionalized elderly individuals. The trial will test household-level treatment of drinking water by joint use of ultraviolet light and filtration devices. A secondary objective is an estimate of the incidence of specific bacterial, viral, and protozoan agents in stool specimens collected from elderly individuals with gastrointestinal symptoms that might be related to water consumption.

Conditions

Diarrhea; Gastrointestinal Diseases

Keywords

Drinking Water

Interventions

home drinking water treatment device DEVICE

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years or older
• primary source of drinking water used at home is supplied by Sonoma County Water Agency without use of home filtration device or bottled water
• all individuals living in the home must sign informed consent and agree to have the water treatment device installed
• no known immunocompromising conditions (including HIV/AIDS, active cancer, or transplant recipients).

You may not qualify if:

• persons with immunocompromising condition (including HIV/AIDS, active cancer, or transplant recipients)
• employees and family members of the Sonoma County Water Agency or a Sonoma County Water District

Sponsors & Collaborators

• National Institute on Aging (NIA): lead

Study Sites (1)

University of California Berkeley

Berkeley, California, 94720, United States

Location

Related Publications (2)

• Payment P, Richardson L, Siemiatycki J, Dewar R, Edwardes M, Franco E. A randomized trial to evaluate the risk of gastrointestinal disease due to consumption of drinking water meeting current microbiological standards. Am J Public Health. 1991 Jun;81(6):703-8. doi: 10.2105/ajph.81.6.703.

  PMID: 2029037 BACKGROUND

• Goldstein ST, Juranek DD, Ravenholt O, Hightower AW, Martin DG, Mesnik JL, Griffiths SD, Bryant AJ, Reich RR, Herwaldt BL. Cryptosporidiosis: an outbreak associated with drinking water despite state-of-the-art water treatment. Ann Intern Med. 1996 Mar 1;124(5):459-68. doi: 10.7326/0003-4819-124-5-199603010-00001.

  PMID: 8602703 BACKGROUND

MeSH Terms

Conditions

Diarrhea; Gastrointestinal Diseases

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Digestive System Diseases

Study Officials

• John M. Colford, M.D., Ph.D.

  School of Public Health, University of California at Berkeley

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: NIH

Study Record Dates

• First Submitted: April 15, 2003
• First Posted: April 16, 2003
• Study Start: January 1, 2000
• Primary Completion: November 1, 2006
• Study Completion: November 1, 2006
• Last Updated: December 11, 2009

Record last verified: 2006-11

Locations

US (1)