NCT00051389

Brief Summary

To determine the effects of an angiotensin converting enzyme inhibitor (ACE inhibitor), fosinopril, on multiple blood markers in 286 adults at high risk for cardiovascular disease.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Feb 2002

Longer than P75 for phase_2 cardiovascular-diseases

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2002

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

January 9, 2003

Completed
4 days until next milestone

First Posted

Study publicly available on registry

January 13, 2003

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2007

Completed
Last Updated

February 18, 2016

Status Verified

January 1, 2008

Enrollment Period

4.9 years

First QC Date

January 9, 2003

Last Update Submit

February 17, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Interventions

FosinoprilDRUG

Eligibility Criteria

Age55 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (1)

  • Cesari M, Kritchevsky SB, Baumgartner RN, Atkinson HH, Penninx BW, Lenchik L, Palla SL, Ambrosius WT, Tracy RP, Pahor M. Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr. 2005 Aug;82(2):428-34. doi: 10.1093/ajcn.82.2.428.

    PMID: 16087989BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Interventions

Fosinopril

Condition Hierarchy (Ancestors)

Vascular Diseases

Intervention Hierarchy (Ancestors)

Phosphinic AcidsOrganophosphorus CompoundsOrganic ChemicalsProlineImino AcidsAmino Acids, CyclicAmino AcidsAmino Acids, Peptides, and Proteins

Study Officials

  • Marco Pahor

    Wake Forest University Health Sciences

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
NIH

Study Record Dates

First Submitted

January 9, 2003

First Posted

January 13, 2003

Study Start

February 1, 2002

Primary Completion

January 1, 2007

Study Completion

January 1, 2007

Last Updated

February 18, 2016

Record last verified: 2008-01