Screening for Childhood-Onset Psychotic Disorders

NCT00049738 | Terminated

• 2 other identifiers: 03003503-M-0035
• Study Type: observational
• Target: 123
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to screen and evaluate children with psychotic disorders to establish or confirm their diagnosis and to collect data about their condition. This study will also recruit individuals for various treatment studies. Childhood psychotic disorders are debilitating conditions in which children have auditory or visual hallucinations and disorganized thoughts. This study will examine psychotic disorders in children in an inpatient setting. Participants in this study will be admitted to the NIH Clinical Center for up to 9 weeks under one or more of the following conditions: current medication, no medication, or tapered medication. Participants will undergo blood, urine, metabolic, and intellectual functioning tests. An electrocardiogram (EKG) and electroencephalogram (EEG) will be performed. A magnetic resonance imaging (MRI) scan of the brain will be taken and infrared oculography will be used to measure eye movements. Participants and their family members may also be asked to participate in a study of genetics in children with psychotic illnesses. Children meeting criteria for childhood onset schizophrenia may be offered participation in a medication comparison protocol.

Conditions

Childhood Onset Psychotic Disorders; Schizophrenia; Psychosis; Psychotic Disorder

Keywords

Psychosis; Childhood Onset Schizophrenia; Schizophrenia; Schizoaffective; Psychotic Disorder; Multidimensionally Impaired Syndrome

Outcome Measures

Primary Outcomes (1)

• Accurate Diagnosis

  On going

Eligibility Criteria

• Age: 5 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Males and females between the ages of 5 and 18
• Onset of psychotic symptoms before 13th birthday and a presumptive diagnosis of either schizophrenia, schizoaffective disorder, MDI syndrome, or psychosis NOS
• Pre-psychotic IQ 70 or above.

You may not qualify if:

• Major neurological or medical condition (e.g. temporal lobe epilepsy for which patient is on active treatment), or other psychiatric diagnosis that is the main focus of treatment (e.g. serious eating disorder).

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (8)

• Cantor S, Evans J, Pearce J, Pezzot-Pearce T. Childhood schizophrenia: present but not accounted for. Am J Psychiatry. 1982 Jun;139(6):758-62. doi: 10.1176/ajp.139.6.758.

  PMID: 7081488 BACKGROUND

• Green WH, Campbell M, Hardesty AS, Grega DM, Padron-Gayol M, Shell J, Erlenmeyer-Kimling L. A comparison of schizophrenic and autistic children. J Am Acad Child Psychiatry. 1984 Jul;23(4):399-409. doi: 10.1016/s0002-7138(09)60317-4. No abstract available.

  PMID: 6747145 BACKGROUND

• Beitchman JH. Childhood schizophrenia. A review and comparison with adult-onset schizophrenia. Psychiatr Clin North Am. 1985 Dec;8(4):793-814.

  PMID: 3878510 BACKGROUND

• Markovic A, Buckley A, Driver DI, Dillard-Broadnax D, Gochman PA, Hoedlmoser K, Rapoport JL, Tarokh L. Sleep spindle activity in childhood onset schizophrenia: Diminished and associated with clinical symptoms. Schizophr Res. 2020 Sep;223:327-336. doi: 10.1016/j.schres.2020.08.022. Epub 2020 Sep 24.

  PMID: 32980206 DERIVED

• Craddock KES, Zhou X, Liu S, Gochman P, Dickinson D, Rapoport JL. Symptom dimensions and subgroups in childhood-onset schizophrenia. Schizophr Res. 2018 Jul;197:71-77. doi: 10.1016/j.schres.2017.10.045. Epub 2017 Nov 13.

  PMID: 29146021 DERIVED

• Kasoff LI, Ahn K, Gochman P, Broadnax DD, Rapoport JL. Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia. J Child Adolesc Psychopharmacol. 2016 Jun;26(5):428-35. doi: 10.1089/cap.2015.0103. Epub 2016 Jan 19.

  PMID: 26784704 DERIVED

• Berman RA, Gotts SJ, McAdams HM, Greenstein D, Lalonde F, Clasen L, Watsky RE, Shora L, Ordonez AE, Raznahan A, Martin A, Gogtay N, Rapoport J. Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia. Brain. 2016 Jan;139(Pt 1):276-91. doi: 10.1093/brain/awv306. Epub 2015 Oct 22.

  PMID: 26493637 DERIVED

• Anvari AA, Friedman LA, Greenstein D, Gochman P, Gogtay N, Rapoport JL. Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia. Psychol Med. 2015;45(12):2667-74. doi: 10.1017/S0033291715000677. Epub 2015 May 4.

  PMID: 25936396 DERIVED

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders; Schizophrenia, Childhood

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Neurodevelopmental Disorders

Study Officials

• Judith L Rapoport, M.D.

  National Institute of Mental Health (NIMH)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 12, 2002
• First Posted: November 13, 2002
• Study Start: October 29, 2002
• Study Completion: October 5, 2017
• Last Updated: October 9, 2017

Record last verified: 2017-10-05

Locations

US (1)