NCT00043576

Brief Summary

The purposes of this study are to determine if DN-101 plus Taxotere lowers PSA levels, delays or limits disease progression and is safe with minimal side effects.

Trial Health

47
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
250

participants targeted

Target at P75+ for phase_2 prostate-cancer

Timeline
Completed

Started Aug 2002

Geographic Reach
2 countries

62 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2002

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

August 9, 2002

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 13, 2002

Completed
3.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2005

Completed
Last Updated

March 12, 2009

Status Verified

February 1, 2005

First QC Date

August 9, 2002

Last Update Submit

March 10, 2009

Conditions

Keywords

Prostate CancerAndrogen Independent Prostate Cancer

Interventions

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
* Three rising PSA measurements OR a new metastatic lesion * Adequate liver and kidney function * Ongoing hormonal therapy * No hospitalization for angina, heart attack or congestive heart failure within the last 12 months * No kidney stones in the last 5 years

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (62)

Montgomery Cancer Center

Montgomery, Alabama, 36106, United States

Location

Arizona Cancer Center- Scottsdale

Scottsdale, Arizona, 85258, United States

Location

Arizona Cancer Center/Southern Arizona VA HCS

Tucson, Arizona, 85723, United States

Location

Arizona Cancer Center- Tucson

Tucson, Arizona, 85724, United States

Location

University of Arkansas for Medical Sciences / Central AR VA

Little Rock, Arkansas, 72205, United States

Location

Alta Bates Comprehensive Cancer Center

Berkeley, California, 94704, United States

Location

California Cancer Care

Greenbrae, California, 94904, United States

Location

Tower Hematology Oncology Medical Group

Los Angeles, California, 90048, United States

Location

Prostate Oncology Specialist/Pacific Clinical Research

Marina del Rey, California, 90292, United States

Location

UC Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

Location

Southern California Permanente Medical Group

San Diego, California, 92120, United States

Location

Sharp Healthcare

San Diego, California, 92121, United States

Location

Pacific Hematology Oncology Associates

San Francisco, California, 94115, United States

Location

Kaiser- Northern California

Vallejo, California, 94589, United States

Location

San Diego Cancer Center

Vista, California, 92083, United States

Location

Oncology Hematology Associates, Paudre Calley Cancer Ctr.

Fort Collins, Colorado, 80528, United States

Location

University of Miami-Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States

Location

Oncology Hematology Consultants

Sarasota, Florida, 34239, United States

Location

Georgia Urology, P.A.

Atlanta, Georgia, 30342, United States

Location

Georgia Cancer Specialists

Tucker, Georgia, 30084, United States

Location

Loyola University Medical

Maywood, Illinois, 60153, United States

Location

Midwest Cancer Research Group

Skokie, Illinois, 60077, United States

Location

Urologic Associates- P.C.

Davenport, Iowa, 52807, United States

Location

Oncology Hematology Care

Crestview Hills, Kentucky, 41017, United States

Location

Tulane University Hospital and Clinic

New Orleans, Louisiana, 70112, United States

Location

Johns Hopkins University

Baltimore, Maryland, 21232, United States

Location

Associates in Oncology Hematology P.C.

Rockville, Maryland, 20850, United States

Location

Metro Minnesota CCOP

Saint Louis Park, Minnesota, 55416, United States

Location

Missouri Cancer Associates

Columbia, Missouri, 65201, United States

Location

Univ. of Nebraska Medical Center/VA Hospital

Omaha, Nebraska, 68198, United States

Location

New Mexico Cancer Care Associates

Santa Fe, New Mexico, 87505, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

Location

Columbia Presbyterian Medical Center

New York, New York, 10032, United States

Location

Union State Bank Cancer Center

Nyack, New York, 10960, United States

Location

Lincoln Medical & Mental Health Center

The Bronx, New York, 10459, United States

Location

Raleigh Hematology Oncology Clinic

Cary, North Carolina, 27511, United States

Location

The Cleveland Clinic Foundation, Taussig Cancer Center

Cleveland, Ohio, 44195, United States

Location

Mid Ohio Oncology Hematology, Inc.

Columbus, Ohio, 43222, United States

Location

Oregon Health & Sciences University

Portland, Oregon, 97201, United States

Location

NW Kaiser Permanente Portland

Portland, Oregon, 97227, United States

Location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15232, United States

Location

Charleston Hematology Oncology

Charleston, South Carolina, 29403, United States

Location

Medical University of South Carolina - Hollings Cancer Center

Charleston, South Carolina, 29425, United States

Location

University Oncology/ Hematology Associates

Chattanooga, Tennessee, 37403, United States

Location

Boston Baskin Cancer Group

Memphis, Tennessee, 38104, United States

Location

Professional Quality Research

Austin, Texas, 78756, United States

Location

Texas Oncology, P.A.

Dallas, Texas, 75246, United States

Location

Texas Cancer Care

Fort Worth, Texas, 76104, United States

Location

Urology Associates of North Texas

Fort Worth, Texas, 76104, United States

Location

North Texas Regional Cancer Center

Plano, Texas, 75075, United States

Location

Tyler Cancer Center

Tyler, Texas, 75702, United States

Location

University of Washington Cancer Care

Seattle, Washington, 98109, United States

Location

Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada

Location

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Location

Vancouver Cancer Center

Vancouver, British Columbia, V5Z 4E6, Canada

Location

CancerCare Manitoba

Winnipeg, Manitoba, R3E OV9, Canada

Location

London Regional Cancer Centre

London, Ontario, N6A 4L6, Canada

Location

Ottawa Regional Cancer Centre

Ottawa, Ontario, K1H 1C4, Canada

Location

Toronto-Sunnybrook Regional Cancer Center

Toronto, Ontario, M4N 3M5, Canada

Location

Princess Margaret Hospital, University Health Network

Toronto, Ontario, M5G 2M9, Canada

Location

CHUM / Notre-Dame Hospital

Montreal, Quebec, H2L 4M1, Canada

Location

Centre hospitalier universitaire de Quebec, Hotel-Dieu de Quebec

Québec, Quebec, G1R 2J6, Canada

Location

Related Publications (2)

  • Beer TM, Munar M, Henner WD. A Phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalation. Cancer. 2001 Jun 15;91(12):2431-9.

    PMID: 11413535BACKGROUND
  • Beer TM, Eilers KM, Garzotto M, Egorin MJ, Lowe BA, Henner WD. Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer. J Clin Oncol. 2003 Jan 1;21(1):123-8. doi: 10.1200/jco.2003.05.117.

    PMID: 12506180BACKGROUND

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

CalcitriolDocetaxel

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

DihydroxycholecalciferolsHydroxycholecalciferolsCholecalciferolCholestenesCholestanesSteroidsFused-Ring CompoundsPolycyclic CompoundsSterolsVitamin DSecosteroidsMembrane LipidsLipidsTaxoidsCyclodecanesCycloparaffinsHydrocarbons, AlicyclicHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsDiterpenesTerpenes

Study Officials

  • Tomasz Beer, MD

    Oregon Health and Science University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

August 9, 2002

First Posted

August 13, 2002

Study Start

August 1, 2002

Study Completion

December 1, 2005

Last Updated

March 12, 2009

Record last verified: 2005-02

Locations