Reward-Related Processes and Brain Function

NCT00029588 | Completed

• 2 other identifiers: 02009202-M-0092
• Study Type: observational
• Target: 241
• Locations: 1 country
• Sites: 2

Brief Summary

This study will examine and compare brain changes during decision-making in healthy adolescents and adolescents who are anxious or depressed. The findings may provide a better understanding of mechanisms that lead to depression or anxiety. Adolescents between 9 and 17 years of age and adults between 20 and 40 years of age in the following categories will be enrolled in this study:

• Healthy adults
• Healthy adolescents
• Adolescents with major depression
• Adolescents with anxiety disorder (generalized anxiety disorder, social phobia, or/and separation anxiety disorder) The study involves three visits, as follows: Visit 1 Visit 1 consists of three parts for both child and adult participants:
• Part 1: Staff will meet with participants for a standard psychiatric interview, which will include questions about the participants feelings, experiences and behavior both past and present. For adolescent participants, staff will meet with the child alone, the parent alone, and the child and parent together.
• Part 2: Participants will perform a series of simple tasks involving shapes, letters, and numbers. They will have a medical history, physical examination and blood draw. In addition, adolescents will have a urine drug test.
• Part 3: Adults and those adolescents who will undergo magnetic resonance imaging (MRI) in Visit 3 will receive training to familiarize them with the procedure. Visit 2
• Adolescents will again be asked standardized questions regarding their feelings, experiences and behavior, and will then perform a series of simple decision-making tasks on a computer.
• Adults will undergo MRI scanning, as described below in Visit 3 for adolescents. This concludes the participation of adults in the study. Visit 3 Adolescents will have one of the following two procedures: \- Decision-making task using a computer. Small electrodes will be placed on the child s wrists, face and fingers to monitor muscle tone and skin humidity during the task. Or
• MRI, a test that uses a strong magnetic field and radio waves to show changes in brain function. During the scan, the participant lies on a table in a space enclosed by a metal cylinder (the MRI scanner). The procedure takes 60-90 minutes; subjects must lie still for 10-15 minutes at a time. During imaging, the subject will be asked to perform a decision-making task on a computer.

Conditions

Depression

Keywords

fMRI; Adolescents and Adults; Depression; Anxiety; Anxiety Disorder; GAD; Adolescents; Healthy Volunteer; HV; Normal Control

Eligibility Criteria

• Age: 9 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age: Subjects will be males and females, 9-17 and 20-40 years of age.

You may not qualify if:

• Medication status: No history of medication treatment or use of an SSRI \> one month prior to entering the study and fluoxetine \> six months prior to entering the study.
• Severe acute and chronic medical illnesses
• CNS disease: History of brain abnormalities (e.g., neoplasms, subarachnoid cysts), cerebrovascular disease, infectious disease (e.g., abscess), or other neurological disease, or history of head trauma (defined as loss of consciousness \> 3 min).
• IQ lower than 70.
• Metal or electronic objects: Metal plates, certain types of dental braces, cardiac pacemakers, etc., that are sensitive to electromagnetic fields contraindicate MRI scans.
• Claustrophobia: Subjects will be questioned about potential discomfort in being in an enclosed space, such as an MRI scanner.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (2)

Childrens National Medical Center

Washington D.C., District of Columbia, United States

Location

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Rogers RD, Owen AM, Middleton HC, Williams EJ, Pickard JD, Sahakian BJ, Robbins TW. Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J Neurosci. 1999 Oct 15;19(20):9029-38. doi: 10.1523/JNEUROSCI.19-20-09029.1999.

  PMID: 10516320 BACKGROUND

• Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES. Emotional bias and inhibitory control processes in mania and depression. Psychol Med. 1999 Nov;29(6):1307-21. doi: 10.1017/s0033291799001233.

  PMID: 10616937 BACKGROUND

• Elliott R, Sahakian BJ, McKay AP, Herrod JJ, Robbins TW, Paykel ES. Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychol Med. 1996 Sep;26(5):975-89. doi: 10.1017/s0033291700035303.

  PMID: 8878330 BACKGROUND

MeSH Terms

Conditions

Depression; Anxiety Disorders

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mental Disorders

Study Officials

• Monique Ernst, M.D.

  National Institute of Mental Health (NIMH)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 15, 2002
• First Posted: January 16, 2002
• Study Start: January 11, 2002
• Study Completion: July 24, 2017
• Last Updated: October 6, 2017

Record last verified: 2017-07-24

Locations

US (2)