Prevention of Depression in At-Risk Adolescents
5 other identifiers
interventional
316
1 country
4
Brief Summary
This study examines the impact of a group cognitive behavioral program aimed at preventing depressive disorders and symptoms in adolescents at risk for developing depression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable depression
Started Mar 2003
Longer than P75 for not_applicable depression
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2003
CompletedFirst Submitted
Initial submission to the registry
December 2, 2003
CompletedFirst Posted
Study publicly available on registry
December 3, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2009
CompletedJanuary 31, 2022
January 1, 2022
3 years
December 2, 2003
January 25, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Onset of a probable or definite depressive episodes (i.e., Depression Symptom Rating greater or equal to 4)
a score of 4 or greater is considered an onset
Time to a score of 4 or higher between baseline and 9 months using survival analysis
Secondary Outcomes (1)
Number of depression-free days
Measured continuously through Month 33
Study Arms (2)
1= Cognitive behavioral prevention of depression program
EXPERIMENTALParticipants receive a group cognitive-behavioral prevention program, which involved 8 weekly sessions and 6 monthly sessions of CBT skills such as cognitive restructuring, problem-solving, assertivenss, and behavioral activation. Participants in this arm also were able to seek the same kinds of nonstudy treatments as described in the usual care arm.
2 = Usual care
ACTIVE COMPARATORParticipants receive usual care, which involves any type of treatment (e.g., psychotherapy, counseling, pharmacotherapy).
Interventions
Cognitive-behavioral prevention program includes 8 weekly and 6 monthly group sessions.
Eligibility Criteria
You may qualify if:
- A parent has had a depressive disorder during child's life
- Adolescent has had a past depressive episode or has current subsyndromal depressive symptoms measured on the Center for Epidemiological Studies Depression Scale (CES-D)
You may not qualify if:
- adolescent or parent ever diagnosed with bipolar I or schizophrenia;
- adolescent has a current DSM-IV mood disorder diagnosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Vanderbilt Universitylead
- National Institute of Mental Health (NIMH)collaborator
Study Sites (4)
Harvard University Medical School
Boston, Massachusetts, 02115-5794, United States
Kaiser Permanente Center for Health Research
Portland, Oregon, 97227, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213-2593, United States
Vanderbilt University
Nashville, Tennessee, 37203-5721, United States
Related Publications (5)
Garber J, Clarke GN, Weersing VR, Beardslee WR, Brent DA, Gladstone TR, DeBar LL, Lynch FL, D'Angelo E, Hollon SD, Shamseddeen W, Iyengar S. Prevention of depression in at-risk adolescents: a randomized controlled trial. JAMA. 2009 Jun 3;301(21):2215-24. doi: 10.1001/jama.2009.788.
PMID: 19491183RESULTBeardslee WR, Brent DA, Weersing VR, Clarke GN, Porta G, Hollon SD, Gladstone TR, Gallop R, Lynch FL, Iyengar S, DeBar L, Garber J. Prevention of depression in at-risk adolescents: longer-term effects. JAMA Psychiatry. 2013 Nov;70(11):1161-70. doi: 10.1001/jamapsychiatry.2013.295.
PMID: 24005242RESULTBrent DA, Brunwasser SM, Hollon SD, Weersing VR, Clarke GN, Dickerson JF, Beardslee WR, Gladstone TR, Porta G, Lynch FL, Iyengar S, Garber J. Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559.
PMID: 26421861RESULTLynch FL, Dickerson JF, Clarke GN, Beardslee WR, Weersing VR, Gladstone TRG, Porta G, Brent DA, Mark TL, DeBar LL, Hollon SD, Garber J. Cost-Effectiveness of Preventing Depression Among At-Risk Youths: Postintervention and 2-Year Follow-Up. Psychiatr Serv. 2019 Apr 1;70(4):279-286. doi: 10.1176/appi.ps.201800144. Epub 2019 Jan 3.
PMID: 30929618DERIVEDWeersing VR, Shamseddeen W, Garber J, Hollon SD, Clarke GN, Beardslee WR, Gladstone TR, Lynch FL, Porta G, Iyengar S, Brent DA. Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects. J Am Acad Child Adolesc Psychiatry. 2016 Mar;55(3):219-26. doi: 10.1016/j.jaac.2015.12.015. Epub 2016 Jan 18.
PMID: 26903255DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Judy Garber, PhD
Vanderbilt University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Masking Details
- Outcome assessor were unaware of condition assignment
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
December 2, 2003
First Posted
December 3, 2003
Study Start
March 1, 2003
Primary Completion
March 1, 2006
Study Completion
January 1, 2009
Last Updated
January 31, 2022
Record last verified: 2022-01