Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

NCT00021528 | Completed Phase 4

• 2 other identifiers: N01MH90003DSIR AT
• Study Type: interventional
• Target: 4,000
• Locations: 1 country
• Sites: 41

Brief Summary

STAR\*D focuses on non-psychotic major depressive disorder in adults who are seen in outpatient settings. The primary purpose of this research study is to determine which treatments work best if the first treatment with medication does not produce an acceptable response. Participants will first receive citalopram, an SSRI medication; if symptoms remain after 8-12 weeks of treatment, up to four other levels of treatment will be offered, including cognitive therapy and other medications. There are no placebo treatments. Some patients may require a combination of two or more treatments to obtain full benefit. Participation could last from 15 to 27 months and involve up to 30 clinic visits. Participants will be interviewed by telephone throughout the study about their symptoms, daily functioning, treatment side effects, use of the health care system, and satisfaction with treatment. There will be a one-year follow up for participants once their depression has been successfully treated

Conditions

Depression

Keywords

Sequential Treatment; Major Depression; Treatment Resistant Depression

Interventions

citalopram DRUG

BuproprionSR DRUG

buspirone DRUG

Lithium DRUG

mirtazapine DRUG

nortriptyline DRUG

sertraline DRUG

tranylcypromine DRUG

VenlafaxineXR DRUG

Cognitive Therapy BEHAVIORAL

T3 (Triiodothyronine) DRUG

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

\- Outpatients aged 18 to 75 years old with nonpsychotic major depressive disorder (HAMD score 14 or greater)

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (41)

Birmingham VA Medical Center

Birmingham, Alabama, 35223, United States

Location

Tuscaloosa VA Mental Health Clinic - Veterans Only

Tuscaloosa, Alabama, 35404, United States

Location

Tuscaloosa VA Primary Care Center

Tuscaloosa, Alabama, 35404, United States

Location

Psychiatric Centers at San Diego

Chula Vista, California, 91910, United States

Location

Harbor UCLA Family Health Care Center

Harbor City, California, 90710, United States

Location

UCLA General Outpatient Psychiatry Clinic

Los Angeles, California, 90024, United States

Location

UCLA Internal Medicine Clinic

Los Angeles, California, 90024, United States

Location

UCSD Outpatient Psychiatric Services

San Diego, California, 92103, United States

Location

Veterans Affairs Medical Center/FIRM Primary Care Clinic

San Diego, California, 92161, United States

Location

Harbor UCLA Medical Center

Torrance, California, 90509, United States

Location

Northwestern Outpatient Treatment Care Center

Chicago, Illinois, 60611, United States

Location

University of Illinois at Chicago Clinic

Chicago, Illinois, 60612, United States

Location

Evanston Outpatient Clinic

Evanston, Illinois, 60201, United States

Location

COMCARE of Sedgwick County

Wichita, Kansas, 67203, United States

Location

Psychiatric Outpatient Clinic

Wichita, Kansas, 67214-2878, United States

Location

Swampscott Family Doctors

Boston, Massachusetts, 01907, United States

Location

Internal Medicine Associates

Boston, Massachusetts, 02114, United States

Location

MGH/Charlestown Clinic

Charlestown, Massachusetts, 02129, United States

Location

MGH/Salem Professional

Salem, Massachusetts, 01970, United States

Location

General Psychiatric Ambulatory Clinic

Ann Arbor, Michigan, 48105-0722, United States

Location

Briarwood Family Practice Clinic

Ann Arbor, Michigan, 48109-0708, United States

Location

LIJ/Zucker Hillside Adult Ambulatory Care Center

Glen Oaks, New York, 11004, United States

Location

LIJ North Shore Medical Group

Lake Success, New York, 11040, United States

Location

UNC Chapel Hill General Medicine Clinic

Chapel Hill, North Carolina, 27599-7110, United States

Location

UNC Chapel Hill Adult Diagnostic & Treatment Clinic

Chapel Hill, North Carolina, 27599-7160, United States

Location

UNC Chapel Hill Family Practice Clinic

Chapel Hill, North Carolina, 27955, United States

Location

Springer Family Medicine

Tulsa, Oklahoma, 74135, United States

Location

Laureate Psychiatric Clinic & Hospital

Tulsa, Oklahoma, 74136, United States

Location

Warren Clinic

Tulsa, Oklahoma, 74136, United States

Location

Diversified Human Services Clinic

Pittsburgh, Pennsylvania, 15062, United States

Location

Latterman Family Health Center

Pittsburgh, Pennsylvania, 15132, United States

Location

Bellefield Clinic of WPIC

Pittsburgh, Pennsylvania, 15213, United States

Location

AMPN Corkery, Heise & Dainesi

Upper Saint Clair, Pennsylvania, 15317, United States

Location

Psychiatric Consultants, P.C.

Nashville, Tennessee, 37203, United States

Location

Vanderbilt University Medical Center-Mental Health Center

Nashville, Tennessee, 37212, United States

Location

Vine Hill Community Clinic

Nashville, Tennessee, 37212, United States

Location

Centerstone/Luton Mental Health Services

Nashville, Tennessee, 37217, United States

Location

The Holiner Psychiatric Group

Dallas, Texas, 75230, United States

Location

UT Southwestern Family Medicine Clinic

Dallas, Texas, 75390, United States

Location

MCV Primary Care Clinic

Richmond, Virginia, 23220, United States

Location

MCV Family Counseling

Richmond, Virginia, 23298-0268, United States

Location

Related Publications (132)

• Adli M, Rush AJ, Moller HJ, Bauer M. Algorithms for optimizing the treatment of depression: making the right decision at the right time. Pharmacopsychiatry. 2003 Nov;36 Suppl 3:S222-9. doi: 10.1055/s-2003-45134.

  PMID: 14677083 BACKGROUND

• Fava M, Rush AJ, Trivedi MH, Nierenberg AA, Thase ME, Sackeim HA, Quitkin FM, Wisniewski S, Lavori PW, Rosenbaum JF, Kupfer DJ. Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. Psychiatr Clin North Am. 2003 Jun;26(2):457-94, x. doi: 10.1016/s0193-953x(02)00107-7.

  PMID: 12778843 BACKGROUND

• Rush AJ, Trivedi M, Fava M. Depression, IV: STAR*D treatment trial for depression. Am J Psychiatry. 2003 Feb;160(2):237. doi: 10.1176/appi.ajp.160.2.237. No abstract available.

  PMID: 12562566 BACKGROUND

• Lavori PW, Rush AJ, Wisniewski SR, Alpert J, Fava M, Kupfer DJ, Nierenberg A, Quitkin FM, Sackeim HA, Thase ME, Trivedi M. Strengthening clinical effectiveness trials: equipoise-stratified randomization. Biol Psychiatry. 2001 Nov 15;50(10):792-801. doi: 10.1016/s0006-3223(01)01223-9.

  PMID: 11720698 BACKGROUND

• Rush AJ, Fava M, Wisniewski SR, Lavori PW, Trivedi MH, Sackeim HA, Thase ME, Nierenberg AA, Quitkin FM, Kashner TM, Kupfer DJ, Rosenbaum JF, Alpert J, Stewart JW, McGrath PJ, Biggs MM, Shores-Wilson K, Lebowitz BD, Ritz L, Niederehe G; STAR*D Investigators Group. Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design. Control Clin Trials. 2004 Feb;25(1):119-42. doi: 10.1016/s0197-2456(03)00112-0.

  PMID: 15061154 BACKGROUND

• Wisniewski SR, Stegman D, Trivedi M, Husain MM, Eng H, Shores-Wilson K, Luther J, Biggs MM, Burroughs D, Ritz AL, Fava M, Quitkin F, Rush AJ; STAR*D Investigators. Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D). J Psychiatr Res. 2004 May-Jun;38(3):241-8. doi: 10.1016/j.jpsychires.2003.06.001.

  PMID: 15003429 BACKGROUND

• Wisniewski SR, Eng H, Meloro L, Gatt R, Ritz L, Stegman D, Trivedi M, Biggs MM, Friedman E, Shores-Wilson K, Warden D, Bartolowits D, Martin JP, Rush AJ. Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project. Clin Trials. 2004;1(4):387-98. doi: 10.1191/1740774504cn035oa.

  PMID: 16279277 BACKGROUND

• Nierenberg AA, Trivedi MH, Ritz L, Burroughs D, Greist J, Sackeim H, Kornstein S, Schwartz T, Stegman D, Fava M, Wisniewski SR. Suicide risk management for the sequenced treatment alternatives to relieve depression study: applied NIMH guidelines. J Psychiatr Res. 2004 Nov-Dec;38(6):583-9. doi: 10.1016/j.jpsychires.2004.03.004.

  PMID: 15458854 BACKGROUND

• Yates WR, Mitchell J, Rush AJ, Trivedi MH, Wisniewski SR, Warden D, Hauger RB, Fava M, Gaynes BN, Husain MM, Bryan C. Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D. Gen Hosp Psychiatry. 2004 Nov-Dec;26(6):421-9. doi: 10.1016/j.genhosppsych.2004.06.008.

  PMID: 15567207 BACKGROUND

• Fava M, Alpert JE, Carmin CN, Wisniewski SR, Trivedi MH, Biggs MM, Shores-Wilson K, Morgan D, Schwartz T, Balasubramani GK, Rush AJ. Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D. Psychol Med. 2004 Oct;34(7):1299-308. doi: 10.1017/s0033291704002612.

  PMID: 15697056 BACKGROUND

• Friedman EF, Thase ME, Biggs MM, Carmin C, Hollon SD, Kornblith SJ, Petersen T, Veenstra G, Wisniewski SR, and Rush AJ. The implementation of cognitive therapy in STAR*D. Cognitive Therapy and Research, 28:819-833, 2004.

  BACKGROUND

• Zisook S, Rush AJ, Albala A, Alpert J, Balasubramani GK, Fava M, Husain M, Sackeim H, Trivedi M, Wisniewski S. Factors that differentiate early vs. later onset of major depression disorder. Psychiatry Res. 2004 Dec 15;129(2):127-40. doi: 10.1016/j.psychres.2004.07.004.

  PMID: 15590040 BACKGROUND

• Davis LL, Rush JA, Wisniewski SR, Rice K, Cassano P, Jewell ME, Biggs MM, Shores-Wilson K, Balasubramani GK, Husain MM, Quitkin FM, McGrath PJ. Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort. Compr Psychiatry. 2005 Mar-Apr;46(2):81-9. doi: 10.1016/j.comppsych.2004.07.025.

  PMID: 15723023 BACKGROUND

• Perlis RH, Fraguas R, Fava M, Trivedi MH, Luther JF, Wisniewski SR, Rush AJ. Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study. J Clin Psychiatry. 2005 Feb;66(2):159-66; quiz 147, 273-4.

  PMID: 15705000 BACKGROUND

• Warden D, Rush AJ, Trivedi M, Ritz L, Stegman D, Wisniewski SR. Quality improvement methods as applied to a multicenter effectiveness trial--STAR*D. Contemp Clin Trials. 2005 Feb;26(1):95-112. doi: 10.1016/j.cct.2004.11.011. Epub 2005 Jan 27.

  PMID: 15837455 BACKGROUND

• Gaynes BN, Rush AJ, Trivedi M, Wisniewski SR, Balasubramani GK, Spencer DC, Petersen T, Klinkman M, Warden D, Schneider RK, Castro DB, Golden RN. A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trial. Gen Hosp Psychiatry. 2005 Mar-Apr;27(2):87-96. doi: 10.1016/j.genhosppsych.2004.10.003.

  PMID: 15763119 BACKGROUND

• Kornstein SG, Harvey AT, Rush AJ, Wisniewski SR, Trivedi MH, Svikis DS, McKenzie ND, Bryan C, Harley R. Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression. Psychol Med. 2005 May;35(5):683-92. doi: 10.1017/s0033291704004106.

  PMID: 15918345 BACKGROUND

• Rush AJ, Zimmerman M, Wisniewski SR, Fava M, Hollon SD, Warden D, Biggs MM, Shores-Wilson K, Shelton RC, Luther JF, Thomas B, Trivedi MH. Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. J Affect Disord. 2005 Jul;87(1):43-55. doi: 10.1016/j.jad.2005.03.005.

  PMID: 15894381 BACKGROUND

• Marcus SM, Young EA, Kerber KB, Kornstein S, Farabaugh AH, Mitchell J, Wisniewski SR, Balasubramani GK, Trivedi MH, Rush AJ. Gender differences in depression: findings from the STAR*D study. J Affect Disord. 2005 Aug;87(2-3):141-50. doi: 10.1016/j.jad.2004.09.008.

  PMID: 15982748 BACKGROUND

• Lesser IM, Leuchter AF, Trivedi MH, Davis LL, Wisniewski SR, Balasubramani GK, Petersen T, Stegman D, Rush AJ. Characteristics of insured and noninsured outpatients with depression in STAR(*)D. Psychiatr Serv. 2005 Aug;56(8):995-1004. doi: 10.1176/appi.ps.56.8.995.

  PMID: 16088018 BACKGROUND

• Novick JS, Stewart JW, Wisniewski SR, Cook IA, Manev R, Nierenberg AA, Rosenbaum JF, Shores-Wilson K, Balasubramani GK, Biggs MM, Zisook S, Rush AJ; STAR*D investigators. Clinical and demographic features of atypical depression in outpatients with major depressive disorder: preliminary findings from STAR*D. J Clin Psychiatry. 2005 Aug;66(8):1002-11. doi: 10.4088/jcp.v66n0807.

  PMID: 16086615 BACKGROUND

• Husain MM, Rush AJ, Sackeim HA, Wisniewski SR, McClintock SM, Craven N, Holiner J, Mitchell JR, Balasubramani GK, Hauger R. Age-related characteristics of depression: a preliminary STAR*D report. Am J Geriatr Psychiatry. 2005 Oct;13(10):852-60. doi: 10.1176/appi.ajgp.13.10.852.

  PMID: 16223963 BACKGROUND

• Gaynes, B.N., Davis, L., Rush A.J., Trivedi, M., Fava, M., Wisniewski, S.R. The aims and design of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Primary Psychiatry, 12(2):36-41, 2005.

  BACKGROUND

• Friedman EF, Thase ME, Biggs MM, Carmin C, Hollon SD, Kornblith SJ, Petersen T, Veenstra G, Wisniewski SR, Rush AJ. The implementation of cognitive therapy in STAR*D. Cognit Ther Res 2004;28:819-33.

  BACKGROUND

• Gaynes BN, Davis L, Rush AJ, Trivedi MH, Fava M, Wisniewski SR. The aims and design of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Primary Psychiatry 2005;12(2):36-41. http://www.primarypsychiatry.com/pdf/art_4845.pdf

  BACKGROUND

• Gilmer WS, Trivedi MH, Rush AJ, Wisniewski SR, Luther J, Howland RH, Yohanna D, Khan A, Alpert J. Factors associated with chronic depressive episodes: a preliminary report from the STAR-D project. Acta Psychiatr Scand. 2005 Dec;112(6):425-33. doi: 10.1111/j.1600-0447.2005.00633.x.

  PMID: 16279871 BACKGROUND

• Hollon SD, Shelton RC, Wisniewski S, Warden D, Biggs MM, Friedman ES, Husain M, Kupfer DJ, Nierenberg AA, Petersen TJ, Shores-Wilson K, Rush AJ. Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trial. J Psychiatr Res. 2006 Feb;40(1):59-69. doi: 10.1016/j.jpsychires.2005.07.008. Epub 2005 Oct 21.

  PMID: 16243357 BACKGROUND

• Rush AJ, Bernstein IH, Trivedi MH, Carmody TJ, Wisniewski S, Mundt JC, Shores-Wilson K, Biggs MM, Woo A, Nierenberg AA, Fava M. An evaluation of the quick inventory of depressive symptomatology and the hamilton rating scale for depression: a sequenced treatment alternatives to relieve depression trial report. Biol Psychiatry. 2006 Mar 15;59(6):493-501. doi: 10.1016/j.biopsych.2005.08.022. Epub 2005 Sep 30.

  PMID: 16199008 BACKGROUND

• Davis LL, Frazier E, Husain MM, Warden D, Trivedi M, Fava M, Cassano P, McGrath PJ, Balasubramani GK, Wisniewski SR, Rush AJ. Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort. Am J Addict. 2006 Jul-Aug;15(4):278-85. doi: 10.1080/10550490600754317.

  PMID: 16867922 BACKGROUND

• Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramani GK, Fava M; STAR*D Study Team. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry. 2006 Jan;163(1):28-40. doi: 10.1176/appi.ajp.163.1.28.

  PMID: 16390886 RESULT

• Pilowsky DJ, Wickramaratne PJ, Rush AJ, Hughes CW, Garber J, Malloy E, King CA, Cerda G, Sood AB, Alpert JE, Wisniewski SR, Trivedi MH, Talati A, Carlson MM, Liu HH, Fava M, Weissman MM. Children of currently depressed mothers: a STAR*D ancillary study. J Clin Psychiatry. 2006 Jan;67(1):126-36. doi: 10.4088/jcp.v67n0119.

  PMID: 16426099 RESULT

• Trivedi MH, Rush AJ, Wisniewski SR, Warden D, McKinney W, Downing M, Berman SR, Farabaugh A, Luther JF, Nierenberg AA, Callan JA, Sackeim HA. Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D report. J Clin Psychiatry. 2006 Feb;67(2):185-95. doi: 10.4088/jcp.v67n0203.

  PMID: 16566612 RESULT

• Rush AJ, Trivedi MH, Wisniewski SR, Stewart JW, Nierenberg AA, Thase ME, Ritz L, Biggs MM, Warden D, Luther JF, Shores-Wilson K, Niederehe G, Fava M; STAR*D Study Team. Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. N Engl J Med. 2006 Mar 23;354(12):1231-42. doi: 10.1056/NEJMoa052963.

  PMID: 16554525 RESULT

• Weissman MM, Pilowsky DJ, Wickramaratne PJ, Talati A, Wisniewski SR, Fava M, Hughes CW, Garber J, Malloy E, King CA, Cerda G, Sood AB, Alpert JE, Trivedi MH, Rush AJ; STAR*D-Child Team. Remissions in maternal depression and child psychopathology: a STAR*D-child report. JAMA. 2006 Mar 22;295(12):1389-98. doi: 10.1001/jama.295.12.1389.

  PMID: 16551710 RESULT

• Trivedi MH, Fava M, Wisniewski SR, Thase ME, Quitkin F, Warden D, Ritz L, Nierenberg AA, Lebowitz BD, Biggs MM, Luther JF, Shores-Wilson K, Rush AJ; STAR*D Study Team. Medication augmentation after the failure of SSRIs for depression. N Engl J Med. 2006 Mar 23;354(12):1243-52. doi: 10.1056/NEJMoa052964.

  PMID: 16554526 RESULT

• Fava M, Rush AJ, Wisniewski SR, Nierenberg AA, Alpert JE, McGrath PJ, Thase ME, Warden D, Biggs M, Luther JF, Niederehe G, Ritz L, Trivedi MH. A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. Am J Psychiatry. 2006 Jul;163(7):1161-72. doi: 10.1176/ajp.2006.163.7.1161.

  PMID: 16816220 RESULT

• McGrath PJ, Stewart JW, Fava M, Trivedi MH, Wisniewski SR, Nierenberg AA, Thase ME, Davis L, Biggs MM, Shores-Wilson K, Luther JF, Niederehe G, Warden D, Rush AJ. Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry. 2006 Sep;163(9):1531-41; quiz 1666. doi: 10.1176/ajp.2006.163.9.1531.

  PMID: 16946177 RESULT

• Nierenberg AA, Fava M, Trivedi MH, Wisniewski SR, Thase ME, McGrath PJ, Alpert JE, Warden D, Luther JF, Niederehe G, Lebowitz B, Shores-Wilson K, Rush AJ. A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. Am J Psychiatry. 2006 Sep;163(9):1519-30; quiz 1665. doi: 10.1176/ajp.2006.163.9.1519.

  PMID: 16946176 RESULT

• Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006 Nov;163(11):1905-17. doi: 10.1176/ajp.2006.163.11.1905.

  PMID: 17074942 RESULT

• McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJM, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet. 2006 May;78(5):804-814. doi: 10.1086/503820. Epub 2006 Mar 20.

  PMID: 16642436 RESULT

• Alpert JE, Biggs MM, Davis L, Shores-Wilson K, Harlan WR, Schneider GW, Ford AL, Farabaugh A, Stegman D, Ritz AL, Husain MM, Macleod L, Wisniewski SR, Rush AJ; STAR*D Investigators. Enrolling research subjects from clinical practice: ethical and procedural issues in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Psychiatry Res. 2006 Feb 28;141(2):193-200. doi: 10.1016/j.psychres.2005.04.007. Epub 2006 Feb 2.

  PMID: 16457894 RESULT

• Khan AY, Carrithers J, Preskorn SH, Lear R, Wisniewski SR, John Rush A, Stegman D, Kelley C, Kreiner K, Nierenberg AA, Fava M. Clinical and demographic factors associated with DSM-IV melancholic depression. Ann Clin Psychiatry. 2006 Apr-Jun;18(2):91-8. doi: 10.1080/10401230600614496.

  PMID: 16754414 RESULT

• Wisniewski SR, Leon AC, Otto MW, Trivedi MH. Prevention of missing data in clinical research studies. Biol Psychiatry. 2006 Jun 1;59(11):997-1000. doi: 10.1016/j.biopsych.2006.01.017. Epub 2006 Mar 29.

  PMID: 16566901 RESULT

• Fava M, Rush AJ. Current status of augmentation and combination treatments for major depressive disorder: a literature review and a proposal for a novel approach to improve practice. Psychother Psychosom. 2006;75(3):139-53. doi: 10.1159/000091771.

  PMID: 16636629 RESULT

• Nierenberg AA, Trivedi MH, Fava M, Biggs MM, Shores-Wilson K, Wisniewski SR, Balasubramani GK, Rush AJ. Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study. J Psychiatr Res. 2007 Apr-Jun;41(3-4):214-21. doi: 10.1016/j.jpsychires.2006.02.005. Epub 2006 May 11.

  PMID: 16690084 RESULT

• Claassen CA, Trivedi MH, Rush AJ, Husain MM, Zisook S, Young E, Leuchter A, Wisniewski SR, Balasubramani GK, Alpert J. Clinical differences among depressed patients with and without a history of suicide attempts: findings from the STAR*D trial. J Affect Disord. 2007 Jan;97(1-3):77-84. doi: 10.1016/j.jad.2006.05.026. Epub 2006 Jul 7.

  PMID: 16824617 RESULT

• Gilmer WS, Kemp DE. STAR*D: What Have We Learned Thus Far? International Drug Therapy Newsletter 41:75-82, 2006.

  RESULT

• Fava M, Rush AJ, Alpert JE, Carmin CN, Balasubramani GK, Wisniewski SR, Trivedi MH, Biggs MM, Shores-Wilson K. What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extension. Can J Psychiatry. 2006 Nov;51(13):823-35. doi: 10.1177/070674370605101304.

  PMID: 17195602 RESULT

• Murphy SA, Oslin DW, Rush AJ, Zhu J; MCATS. Methodological challenges in constructing effective treatment sequences for chronic psychiatric disorders. Neuropsychopharmacology. 2007 Feb;32(2):257-62. doi: 10.1038/sj.npp.1301241. Epub 2006 Nov 8.

  PMID: 17091129 RESULT

• Zisook S, Rush AJ, Lesser I, Wisniewski SR, Trivedi M, Husain MM, Balasubramani GK, Alpert JE, Fava M. Preadult onset vs. adult onset of major depressive disorder: a replication study. Acta Psychiatr Scand. 2007 Mar;115(3):196-205. doi: 10.1111/j.1600-0447.2006.00868.x.

  PMID: 17302619 RESULT

• Phaterpekar T, Nunez JJ, Morton E, Liu YS, Cao B, Frey BN, Milev RV, Muller DJ, Rotzinger S, Soares CN, Taylor VH, Uher R, Kennedy SH, Lam RW. Machine Learning Prediction of Quality of Life Improvement During Antidepressant Treatment of Patients With Major Depressive Disorder: A STAR*D and CAN-BIND-1 Report. J Clin Psychiatry. 2023 Nov 15;85(1):23m14864. doi: 10.4088/JCP.23m14864.

  PMID: 37967350 DERIVED

• Shah SB, Peddada TN, Song C, Mensah M, Sung H, Yavi M, Yuan P, Zarate CA Jr, Mickey BJ, Burmeister M, Akula N, McMahon FJ. Exome-wide association study of treatment-resistant depression suggests novel treatment targets. Sci Rep. 2023 Aug 1;13(1):12467. doi: 10.1038/s41598-023-38984-z.

  PMID: 37528149 DERIVED

• Salem H, Huynh T, Topolski N, Mwangi B, Trivedi MH, Soares JC, Rush AJ, Selvaraj S. Temporal multi-step predictive modeling of remission in major depressive disorder using early stage treatment data; STAR*D based machine learning approach. J Affect Disord. 2023 Mar 1;324:286-293. doi: 10.1016/j.jad.2022.12.076. Epub 2022 Dec 28.

  PMID: 36584711 DERIVED

• Oliva V, Fanelli G, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, Kas MJ, De Ronchi D, Fabbri C, Serretti A. Social withdrawal as a trans-diagnostic predictor of short-term remission: a meta-analysis of five clinical cohorts. Int Clin Psychopharmacol. 2022 Mar 1;37(2):38-45. doi: 10.1097/YIC.0000000000000384.

  PMID: 34855649 DERIVED

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• Stewart JW, McGrath PJ, Fava M, Wisniewski SR, Zisook S, Cook I, Nierenberg AA, Trivedi MH, Balasubramani GK, Warden D, Lesser I, John Rush A. Do atypical features affect outcome in depressed outpatients treated with citalopram? Int J Neuropsychopharmacol. 2010 Feb;13(1):15-30. doi: 10.1017/S1461145709000182. Epub 2009 Apr 3.

  PMID: 19341509 DERIVED

• Wisniewski SR, Rush AJ, Nierenberg AA, Gaynes BN, Warden D, Luther JF, McGrath PJ, Lavori PW, Thase ME, Fava M, Trivedi MH. Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report. Am J Psychiatry. 2009 May;166(5):599-607. doi: 10.1176/appi.ajp.2008.08071027. Epub 2009 Apr 1.

  PMID: 19339358 DERIVED

• Husain MM, Rush AJ, Wisniewski SR, McClintock SM, Fava M, Nierenberg AA, Davis L, Balasubramani GK, Young E, Albala AA, Trivedi MH. Family history of depression and therapeutic outcome: findings from STAR*D. J Clin Psychiatry. 2009 Feb;70(2):185-95. doi: 10.4088/jcp.07m03571. Epub 2008 Dec 2.

  PMID: 19192454 DERIVED

• McGrath PJ, Khan AY, Trivedi MH, Stewart JW, Morris DW, Wisniewski SR, Miyahara S, Nierenberg AA, Fava M, Rush AJ. Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report. J Clin Psychiatry. 2008 Dec;69(12):1847-55. doi: 10.4088/jcp.v69n1201. Epub 2008 Nov 18.

  PMID: 19026268 DERIVED

• Gilmer WS, Gollan JK, Wisniewski SR, Howland RH, Trivedi MH, Miyahara S, Fleck J, Thase ME, Alpert JE, Nierenberg AA, Warden D, Fava M, Rush AJ. Does the duration of index episode affect the treatment outcome of major depressive disorder? A STAR*D report. J Clin Psychiatry. 2008 Aug;69(8):1246-56. doi: 10.4088/jcp.v69n0807.

  PMID: 18681756 DERIVED

• Rush AJ, Wisniewski SR, Warden D, Luther JF, Davis LL, Fava M, Nierenberg AA, Trivedi MH. Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features. Arch Gen Psychiatry. 2008 Aug;65(8):870-80. doi: 10.1001/archpsyc.65.8.870.

  PMID: 18678792 DERIVED

• Davis LL, Frazier EC, Gaynes BN, Trivedi MH, Wisniewski SR, Fava M, Barkin J, Kashner TM, Shelton RC, Alpert JE, Rush AJ. Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort. J Clin Psychiatry. 2007 Dec;68(12):1931-8. doi: 10.4088/jcp.v68n1214.

  PMID: 18162025 DERIVED

Related Links

• More information on depression

MeSH Terms

Conditions

Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant

Interventions

Citalopram; Buspirone; Lithium; Mirtazapine; Nortriptyline; Sertraline; Tranylcypromine; Cognitive Behavioral Therapy; Triiodothyronine

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Propylamines; Amines; Organic Chemicals; Nitriles; Benzofurans; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Spiro Compounds; Hydrocarbons, Cyclic; Hydrocarbons; Piperazines; Heterocyclic Compounds, 1-Ring; Pyrimidines; Polycyclic Compounds; Metals, Alkali; Elements; Inorganic Chemicals; Metals, Light; Metals; Dibenzazepines; Heterocyclic Compounds, 3-Ring; Dibenzocycloheptenes; Benzocycloheptenes; Polycyclic Aromatic Hydrocarbons; Hydrocarbons, Aromatic; 1-Naphthylamine; Naphthalenes; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities; Thyronines; Thyroid Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Thyroxine; Amino Acids, Aromatic; Amino Acids, Cyclic; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• A. John Rush, MD

  University of Texas Southwestern Medical Center Department of Psychiatry

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: NIH

Study Record Dates

• First Submitted: July 20, 2001
• First Posted: July 23, 2001
• Study Start: July 1, 2001
• Study Completion: September 1, 2006
• Last Updated: September 25, 2009

Record last verified: 2006-09

Locations

US (41)