Treatment for Post-Stroke Depression
1 other identifier
interventional
188
1 country
4
Brief Summary
The purpose of this study is to evaluate a program of education, medicine, and monitoring for the treatment of depression after a stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4 stroke
Started May 1999
Longer than P75 for phase_4 stroke
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 1999
CompletedFirst Submitted
Initial submission to the registry
January 8, 2002
CompletedFirst Posted
Study publicly available on registry
January 9, 2002
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2005
CompletedResults Posted
Study results publicly available
January 28, 2010
CompletedFebruary 16, 2023
December 1, 2009
January 8, 2002
August 3, 2009
January 19, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Twelve Week Depression Outcomes
Depression remission was defined as HAM-D less than 8 or HAM-D decreased by 50%. The Hamilton Rating Scale for Depression is measured on a scale from no depression - major depression, 0-52 units on a scale.
Twelve week
Study Arms (1)
Nurse Case management
EXPERIMENTALInterventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Study Sites (4)
Indiana University Hospital, 550 N. University Blvd.
Indianapolis, Indiana, 46202, United States
Methodist Hospital of Indiana, 1601 N. Capitol
Indianapolis, Indiana, 46202, United States
Roudebush VA Medical Center, Health Services Research and Development 11H, 1481 W. 10th Street
Indianapolis, Indiana, 46202, United States
Wishard Memorial Hospital, 1001 W. 10th Street
Indianapolis, Indiana, 46202, United States
Related Publications (3)
Williams LS, Brizendine EJ, Plue L, Bakas T, Tu W, Hendrie H, Kroenke K. Performance of the PHQ-9 as a screening tool for depression after stroke. Stroke. 2005 Mar;36(3):635-8. doi: 10.1161/01.STR.0000155688.18207.33. Epub 2005 Jan 27.
PMID: 15677576BACKGROUNDWilliams LS, Bakas T, Brizendine E, Plue L, Tu W, Hendrie H, Kroenke K. How valid are family proxy assessments of stroke patients' health-related quality of life? Stroke. 2006 Aug;37(8):2081-5. doi: 10.1161/01.STR.0000230583.10311.9f. Epub 2006 Jun 29.
PMID: 16809575BACKGROUNDWilliams LS, Kroenke K, Bakas T, Plue LD, Brizendine E, Tu W, Hendrie H. Care management of poststroke depression: a randomized, controlled trial. Stroke. 2007 Mar;38(3):998-1003. doi: 10.1161/01.STR.0000257319.14023.61. Epub 2007 Feb 15.
PMID: 17303771RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Linda Williams
- Organization
- Roudebush VAMC Center of Excellence
Study Officials
- PRINCIPAL INVESTIGATOR
Linda Williams, M.D.
Roudebush VA Medical Center Health Services Research and Development 11H
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 8, 2002
First Posted
January 9, 2002
Study Start
May 1, 1999
Study Completion
December 1, 2005
Last Updated
February 16, 2023
Results First Posted
January 28, 2010
Record last verified: 2009-12