Comparison of Externally and Self-Initiated Movements

NCT00028197 | Completed

• 2 other identifiers: 02006802-N-0068
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

This study will use magnetic resonance imaging (MRI) to investigate how the brain controls voluntary movements triggered by an external stimulus or self-initiated. Registered HCMS healthy normal volunteers may participate. They will complete a questionnaire and will have a medical history and brief physical examination. The study consists of two parts: 1) body movement training and 2) magnetic resonance imaging, as follows: Part 1 - Body movement training Participants will train to do three different body movements involving the hands and feet. The movements will either be self-initiated or in response to a stimulus, such as a visual or auditory trigger. Part 2 - Magnetic resonance imaging Participants will do one or more of the trained movements, with or without a triggering stimulus, during MRI scanning. MRI is a diagnostic procedure that uses a magnetic field and radio waves to produce images of brain structure and activity. For the procedure, the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet. Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits. Scanning time varies from 20 minutes to 2 hours, with most examinations lasting 1 to 1-1/2 hours. The subject can communicate with the staff person conducting the test at all times during the scan. A device compatible with magnetic resonance will be used to record the participant's body movements. The participant may be asked to push buttons of the device during the tasks.

Conditions

Healthy

Keywords

Voluntary Movement; Functional MRI; Sensorimotor Integration; Superior Parietal Lobe; Supplementary Motor Area; Normal Control; HV; Healthy Volunteer

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Normal volunteers will be included. Normal volunteers will be recruited from people who are registered as HMCS Normal Volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.

You may not qualify if:

• We will not scan pregnant women because safety of high magnetic field to fetus is not established. Therefore, we will administer a urine pregnancy test for any female subjects of childbearing potential prior to functional MRI scan. If the result from a urine pregnancy test is not available for some reason, a medical doctor will judge based on the proper information prior to the scanning.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Alexander GE, Crutcher MD. Neural representations of the target (goal) of visually guided arm movements in three motor areas of the monkey. J Neurophysiol. 1990 Jul;64(1):164-78. doi: 10.1152/jn.1990.64.1.164.

  PMID: 2388063 BACKGROUND

• Brinkman C, Porter R. Supplementary motor area and premotor area of monkey cerebral cortex: functional organization and activities of single neurons during performance of a learned movement. Adv Neurol. 1983;39:393-420.

  PMID: 6419554 BACKGROUND

• Burbaud P, Doegle C, Gross C, Bioulac B. A quantitative study of neuronal discharge in areas 5, 2, and 4 of the monkey during fast arm movements. J Neurophysiol. 1991 Aug;66(2):429-43. doi: 10.1152/jn.1991.66.2.429.

  PMID: 1774580 BACKGROUND

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: December 17, 2001
• First Posted: December 18, 2001
• Study Start: December 1, 2001
• Study Completion: November 1, 2005
• Last Updated: March 4, 2008

Record last verified: 2005-11

Locations

US (1)