Brain Changes Associated With Learning a Motor Task

NCT00076466 | Completed

• 2 other identifiers: 04010304-N-0103
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This study will determine: 1) whether learning a task with the dominant hand is accompanied by changes in the area of the brain that controls hand movement, and 2) how the brain is able to make these changes. Previous studies have shown that practicing a motor task can change brain excitability, but it is not known how well brain excitabilities are changed during motor learning. This study will measure changes in activity of the part of the brain that controls hand movement before, during, and after exercising the hand on a response pad. Healthy normal volunteers between 18 and 40 years of age may be eligible for this study. Candidates who have not been evaluated at NIH within the past year will be screened with a brief interview about their current state of health and clinical and neurological examinations. Participants will undergo the following procedures: Learning a finger movement/reaction time task For this procedure, participants sit in front of a computer monitor with the index, middle, ring, and little fingers placed flat on four corresponding buttons of a response pad. They are asked to press one of the four buttons as fast as they can in response to an asterisk displayed on the monitor. The position of the asterisk indicates which button to push. Subjects perform nine sets of 120-button pushes with a 15-minute rest between each set. During the rest period, subjects undergo transcranial magnetic stimulation (described below), which causes twitches in the hand muscles. The electrical activity corresponding to the twitches is recorded by attaching electrodes (small metal disks) to the skin over the hand muscles. Transcranial magnetic stimulation For this test, an insulated wire coil is held over the scalp. A brief electrical current passes through the coil, creating a magnetic pulse that electrically stimulates the brain. The subject hears a click and may feel a pulling sensation on the scalp under the coil. The stimulation may also cause twitching in the muscles of the face, arm, or leg. During the stimulation, the subject may be asked to tense certain muscles slightly or perform other simple actions. ...

Conditions

Healthy

Keywords

Brain Excitability; Reaction Time; Plasticity; Motor Evoked Potential; Transcranial Magnetic Stimulation; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Normal volunteers (aged 18 to 40 years) who are willing to participate and who have not participated yet in a protocol using a serial reaction time task (SRRT) and who are not or were not a piano player.

You may not qualify if:

• Subjects with current use or history of alcohol or drug abuse, psychiatric disorder requiring hospitalization or prolonged treatment, head injury with loss of consciousness, epilepsy, and neurological disease. Subjects receiving drugs acting primarily on the central nervous system.
• Subjects with cardiac pacemakers, intracardiac lines, implanted medication pumps.
• Subjects with eye, blood vessel, cochlear, or eye implants, subjects with increased intracranial pressure as evaluated by clinical means, subjects with metal in the cranium except in the mouth, subjects with dental braces, metal fragments from occupational exposure or surgical clips in or near the brain.
• Since this protocol utilizes paired pulse stimulation, there is no reason to exclude pregnant women. However, women in the last trimester of pregnancy will not be studied because they will likely be uncomfortable for three hours training.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Bridgers SL, Delaney RC. Transcranial magnetic stimulation: an assessment of cognitive and other cerebral effects. Neurology. 1989 Mar;39(3):417-9. doi: 10.1212/wnl.39.3.417.

  PMID: 2927652 BACKGROUND

• Butefisch CM, Davis BC, Wise SP, Sawaki L, Kopylev L, Classen J, Cohen LG. Mechanisms of use-dependent plasticity in the human motor cortex. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3661-5. doi: 10.1073/pnas.97.7.3661.

  PMID: 10716702 BACKGROUND

• Classen J, Liepert J, Wise SP, Hallett M, Cohen LG. Rapid plasticity of human cortical movement representation induced by practice. J Neurophysiol. 1998 Feb;79(2):1117-23. doi: 10.1152/jn.1998.79.2.1117.

  PMID: 9463469 BACKGROUND

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: January 22, 2004
• First Posted: January 23, 2004
• Study Start: January 22, 2004
• Study Completion: January 14, 2009
• Last Updated: July 2, 2017

Record last verified: 2009-01-14

Locations

US (1)