Lead Mobilization & Bone Turnover in Pregnancy/Lactation

NCT00011726 | Completed

• 1 other identifier: 7437-CP-001
• Study Type: observational
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

We are examining the role of maternal bone lead turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and the infant (via breast milk). A cohort, ascertained at entry to care, consists of \>1000 women to be followed through pregnancy. In the postpartum subjects are recruited for a nested case control study to assess the influence of lactation on maternal bone density, maternal blood lead and breast milk lead.

Conditions

Lead Poisoning

Keywords

Pregnancy; Lead Exposure; Lactation; Bone Mineralization; Maternal-Fetal Exchange

Eligibility Criteria

• Age: 12 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

1. Positive pregnancy test, age 12-35 and informed consent; 2. Gestation \<28 weeks at entry to prenatal care; 3. No history of serious chronic or metabolic diseases, which could affect maternal growth or bone density; 4. Not corticosteroid user or diagnosed use of illicit drugs; 5. Eligible for lactation study: Ascertainment during or participation in the pregnancy study and a negative pregnancy test.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Environmental Health Sciences (NIEHS): lead

Related Publications (6)

• Sowers M, Jannausch M, Scholl T, Schall J. The reproducibility of ultrasound bone measures in a triethnic population of pregnant adolescents and adult women. J Bone Miner Res. 1998 Nov;13(11):1768-74. doi: 10.1359/jbmr.1998.13.11.1768.

  PMID: 9797487 BACKGROUND

• Sowers MF, Scholl T, Harris L, Jannausch M. Bone loss in adolescent and adult pregnant women. Obstet Gynecol. 2000 Aug;96(2):189-93. doi: 10.1016/s0029-7844(00)00903-0.

  PMID: 10908761 BACKGROUND

• Scholl TO. High third-trimester ferritin concentration: associations with very preterm delivery, infection, and maternal nutritional status. Obstet Gynecol. 1998 Aug;92(2):161-6. doi: 10.1016/s0029-7844(98)00157-4.

  PMID: 9699743 BACKGROUND

• Goodlin RC. High third-trimester ferritin concentration: associations with very preterm delivery, infection, and maternal nutritional status. Obstet Gynecol. 1999 Jan;93(1):156. doi: 10.1016/s0029-7844(98)00427-x. No abstract available.

  PMID: 9916975 BACKGROUND

• Scholl TO. Teenage pregnancy. In "Cambridge Encyclopedia of Growth and Development", SJ Ulijaszek, FE Johnson, MA Preece (eds), Cambridge Univ Press, 312-13,1998

  BACKGROUND

• Scholl TO, Reilly T. Essential trace elements and mineral nutrition in human pregnancy. In "Clinical nutrition of the essential trace elements and mineral - The Guide for Health Professionals", John R. Bogden, Leslie Klevay (eds), Humana Press, 1999. ( In press)

  BACKGROUND

MeSH Terms

Conditions

Lead Poisoning; Breast Feeding

Condition Hierarchy (Ancestors)

Heavy Metal Poisoning; Poisoning; Chemically-Induced Disorders; Feeding Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: NATURAL HISTORY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 27, 2001
• First Posted: March 1, 2001
• Study Start: August 1, 1996
• Study Completion: December 1, 2002
• Last Updated: March 23, 2006

Record last verified: 2006-03