Characterizing a 5P-Linked BHR Susceptibility Locus

NCT00006512 | Completed

• 2 other identifiers: 948R01HL066533
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To identify the predisposing genes responsible for asthma and bronchial hyperresponsiveness (BHR) at region 5p13.3 in an inbred Hutterite community.

Conditions

Asthma; Lung Diseases

Eligibility Criteria

• Age: Up to 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of Chicago: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Related Publications (16)

• Ober C. Susceptibility genes in asthma and allergy. Curr Allergy Asthma Rep. 2001 Mar;1(2):174-9. doi: 10.1007/s11882-001-0085-4.

  PMID: 11899300 BACKGROUND

• Newman DL, Hoffjan S, Bourgain C, Abney M, Nicolae RI, Profits ET, Grow MA, Walker K, Steiner L, Parry R, Reynolds R, McPeek MS, Cheng S, Ober C. Are common disease susceptibility alleles the same in outbred and founder populations? Eur J Hum Genet. 2004 Jul;12(7):584-90. doi: 10.1038/sj.ejhg.5201191.

  PMID: 15100713 BACKGROUND

• Zollner S, Wen X, Hanchard NA, Herbert MA, Ober C, Pritchard JK. Evidence for extensive transmission distortion in the human genome. Am J Hum Genet. 2004 Jan;74(1):62-72. doi: 10.1086/381131. Epub 2003 Dec 15.

  PMID: 14681832 BACKGROUND

• Weiss LA, Abney M, Cook EH Jr, Ober C. Sex-specific genetic architecture of whole blood serotonin levels. Am J Hum Genet. 2005 Jan;76(1):33-41. doi: 10.1086/426697. Epub 2004 Nov 3.

  PMID: 15526234 BACKGROUND

• Kurz T, Ober C. The role of environmental tobacco smoke in genetic susceptibility to asthma. Curr Opin Allergy Clin Immunol. 2004 Oct;4(5):335-9. doi: 10.1097/00130832-200410000-00002.

  PMID: 15349030 BACKGROUND

• McPeek MS, Wu X, Ober C. Best linear unbiased allele-frequency estimation in complex pedigrees. Biometrics. 2004 Jun;60(2):359-67. doi: 10.1111/j.0006-341X.2004.00180.x.

  PMID: 15180661 BACKGROUND

• Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res. 2003 Dec 4;4(1):14. doi: 10.1186/1465-9921-4-14. Print 2003.

  PMID: 14748924 BACKGROUND

• Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet. 2005 Feb;76(2):349-57. doi: 10.1086/427763. Epub 2004 Dec 20.

  PMID: 15611928 BACKGROUND

• Donfack J, Schneider DH, Tan Z, Kurz T, Dubchak I, Frazer KA, Ober C. Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy. Respir Res. 2005 Dec 10;6(1):145. doi: 10.1186/1465-9921-6-145.

  PMID: 16336695 BACKGROUND

• Ober C. HLA-G: an asthma gene on chromosome 6p. Immunol Allergy Clin North Am. 2005 Nov;25(4):669-79. doi: 10.1016/j.iac.2005.08.001.

  PMID: 16257632 BACKGROUND

• Ober C, Thompson EE. Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol. 2005 Dec;17(6):670-8. doi: 10.1016/j.coi.2005.09.009. Epub 2005 Oct 7.

  PMID: 16214315 BACKGROUND

• Ober C. Perspectives on the past decade of asthma genetics. J Allergy Clin Immunol. 2005 Aug;116(2):274-8. doi: 10.1016/j.jaci.2005.04.039.

  PMID: 16083779 BACKGROUND

• Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI. Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production. J Immunol. 2005 Aug 15;175(4):2061-5. doi: 10.4049/jimmunol.175.4.2061.

  PMID: 16081771 BACKGROUND

• Zhang J, Schneider D, Ober C, McPeek MS. Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals. Genet Epidemiol. 2005 Sep;29(2):128-40. doi: 10.1002/gepi.20081.

  PMID: 16049966 BACKGROUND

• Kurina LM, Weiss LA, Graves SW, Parry R, Williams GH, Abney M, Ober C. Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women. J Clin Endocrinol Metab. 2005 Aug;90(8):4747-52. doi: 10.1210/jc.2005-0384. Epub 2005 Jun 7.

  PMID: 15941864 BACKGROUND

• Weiss LA, Lester LA, Gern JE, Wolf RL, Parry R, Lemanske RF, Solway J, Ober C. Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. Am J Respir Crit Care Med. 2005 Jul 1;172(1):67-73. doi: 10.1164/rccm.200411-1555OC. Epub 2005 Apr 7.

  PMID: 15817799 BACKGROUND

MeSH Terms

Conditions

Asthma; Lung Diseases

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Carole Ober

  University of Chicago

Study Design

• Study Type: observational
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 20, 2000
• First Posted: November 21, 2000
• Study Start: September 1, 2000
• Primary Completion: August 1, 2005
• Study Completion: August 1, 2005
• Last Updated: January 21, 2016

Record last verified: 2016-01