NCT00233285

Brief Summary

To investigate gene-environment interactions that may influence susceptibility to respiratory illness in children living in highly polluted areas in California.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1999

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1999

Completed
6.1 years until next milestone

First Submitted

Initial submission to the registry

October 3, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 5, 2005

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2009

Completed
Last Updated

July 12, 2016

Status Verified

April 1, 2009

Enrollment Period

9.5 years

First QC Date

October 3, 2005

Last Update Submit

July 11, 2016

Conditions

Lung DiseasesAsthma

Eligibility Criteria

AgeUp to 100 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (19)

  • Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet. 2004 Jan 10;363(9403):119-25. doi: 10.1016/S0140-6736(03)15262-2.

    PMID: 14726165BACKGROUND

  • Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. Am J Respir Crit Care Med. 2005 Dec 15;172(12):1563-8. doi: 10.1164/rccm.200503-490OC. Epub 2005 Sep 15.

    PMID: 16166621BACKGROUND

  • Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Hum Genet. 2005 Sep;117(5):476-84. doi: 10.1007/s00439-005-1319-7. Epub 2005 Jul 14.

    PMID: 16021473BACKGROUND

  • Li YF, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest. 2005 Apr;127(4):1232-41. doi: 10.1378/chest.127.4.1232.

    PMID: 15821200BACKGROUND

  • Salam MT, Li YF, Langholz B, Gilliland FD; Children's Health Study. Early-life environmental risk factors for asthma: findings from the Children's Health Study. Environ Health Perspect. 2004 May;112(6):760-5. doi: 10.1289/ehp.6662.

    PMID: 15121522BACKGROUND

  • Gilliland FD, Berhane KT, Li YF, Gauderman WJ, McConnell R, Peters J. Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. Am J Epidemiol. 2003 Sep 15;158(6):576-84. doi: 10.1093/aje/kwg181.

    PMID: 12965883BACKGROUND

  • Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, Avol E, Peters JM. Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol. 2003 Sep 1;158(5):406-15. doi: 10.1093/aje/kwg175.

    PMID: 12936895BACKGROUND

  • Gilliland FD, Berhane K, Islam T, Wenten M, Rappaport E, Avol E, Gauderman WJ, McConnell R, Peters JM. Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren. Am J Epidemiol. 2003 May 15;157(10):861-9. doi: 10.1093/aje/kwg037.

    PMID: 12746237BACKGROUND

  • Gilliland FD, Berhane K, Li YF, Rappaport EB, Peters JM. Effects of early onset asthma and in utero exposure to maternal smoking on childhood lung function. Am J Respir Crit Care Med. 2003 Mar 15;167(6):917-24. doi: 10.1164/rccm.200206-616OC. Epub 2002 Dec 12.

    PMID: 12480608BACKGROUND

  • Xie B, Gilliland FD, Li YF, Rockett HR. Effects of ethnicity, family income, and education on dietary intake among adolescents. Prev Med. 2003 Jan;36(1):30-40. doi: 10.1006/pmed.2002.1131.

    PMID: 12473422BACKGROUND

  • Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002 Aug 15;166(4):457-63. doi: 10.1164/rccm.2112064.

    PMID: 12186820BACKGROUND

  • Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 1;166(3):346-51. doi: 10.1164/rccm.2111048.

    PMID: 12153968BACKGROUND

  • Rappaport EB, Gilliland FD, Linn WS, Gauderman WJ. Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic children. Pediatr Pulmonol. 2002 Aug;34(2):112-21. doi: 10.1002/ppul.10142.

    PMID: 12112777BACKGROUND

  • Gilliland FD, Berhane KT, Li YF, Kim DH, Margolis HG. Dietary magnesium, potassium, sodium, and children's lung function. Am J Epidemiol. 2002 Jan 15;155(2):125-31. doi: 10.1093/aje/155.2.125.

    PMID: 11790675BACKGROUND

  • Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2001 Feb;163(2):429-36. doi: 10.1164/ajrccm.163.2.2006009.

    PMID: 11179118BACKGROUND

  • Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology. 2001 Jan;12(1):43-54. doi: 10.1097/00001648-200101000-00009.

    PMID: 11138819BACKGROUND

  • Li YF, Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. Am J Respir Crit Care Med. 2000 Dec;162(6):2097-104. doi: 10.1164/ajrccm.162.6.2004178.

    PMID: 11112121BACKGROUND

  • Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax. 2000 Apr;55(4):271-6. doi: 10.1136/thorax.55.4.271.

    PMID: 10722765BACKGROUND

  • Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environ Health Perspect. 2005 Oct;113(10):1447-54. doi: 10.1289/ehp.7673.

    PMID: 16203261BACKGROUND

MeSH Terms

Conditions

Lung DiseasesAsthma

Condition Hierarchy (Ancestors)

Respiratory Tract DiseasesBronchial DiseasesLung Diseases, ObstructiveRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Frank Gilliland

    University of Southern California

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

October 3, 2005

First Posted

October 5, 2005

Study Start

September 1, 1999

Primary Completion

March 1, 2009

Study Completion

March 1, 2009

Last Updated

July 12, 2016

Record last verified: 2009-04