Study of Arthritis and Related Conditions

NCT00006333 | Completed

• 2 other identifiers: 00022200-AR-0222
• Study Type: observational
• Target: 697
• Locations: 1 country
• Sites: 1

Brief Summary

This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.

Conditions

Rheumatoid Arthritis

Keywords

Pathogenesis

Outcome Measures

Primary Outcomes (1)

• Determine patterns of arthritis

  Evaluate natural history and disease trajectories in rheumatoid arthritis

  End of the study

Secondary Outcomes (8)

• Confirmatory Studies In RA and related diseases

  End of the study

• Co-culture experiments using synovial tissue and surgical cartilage specimens

  End of the study

• MRI Imaging in RA and related diseases

  End of the study

• Collection of DNA in RA and related diseases

  End of the study

• Evaluation of early disability in RA and related diseases

  End of the study

Study Arms (1)

Subjects with known or suspected arthritis

Subjects with known or suspected arthritis will be evaluated longitudinally

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects with known or suspected arthritis

You may qualify if:

• No age limits.
• History of inflammatory synovitis of at least one or more swollen joints.
• Patient's ability and willingness to give informed consent or in the pediatric patients, the parent's willingness to give informed consent and the patient's willingness to assent to the protocol whenever possible.

Sponsors & Collaborators

• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Links

• NIH Clinical Center Detailed Web Page

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• James D Katz, M.D.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 4, 2000
• First Posted: October 5, 2000
• Study Start: October 3, 2000
• Primary Completion: March 10, 2021
• Study Completion: March 10, 2021
• Last Updated: March 12, 2021

Record last verified: 2021-03

Locations

US (1)