NCT00005767

Brief Summary

This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
unknown

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Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 1, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

June 2, 2000

Completed
Last Updated

June 24, 2005

Status Verified

December 1, 2003

First QC Date

June 1, 2000

Last Update Submit

June 23, 2005

Conditions

Kidney Diseases

Keywords

Amino Acid Metabolism

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • normal weight-for-height weight 50-80 kg
  • normal physical activity
  • no significant medical history
  • healthy by medical exam and lab blood testing

You may not qualify if:

  • subjects who exercise vigorously
  • subjects who smoke

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Vermont

Burlington, Vermont, 05401, United States

RECRUITING

MeSH Terms

Conditions

Kidney Diseases

Condition Hierarchy (Ancestors)

Urologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Central Study Contacts

Dwight Matthews, Ph.D.

CONTACT

1-802-646-8114

Study Design

Study Type
observational
Observational Model
NATURAL HISTORY
Time Perspective
CROSS SECTIONAL
Sponsor Type
NIH

Study Record Dates

First Submitted

June 1, 2000

First Posted

June 2, 2000

Last Updated

June 24, 2005

Record last verified: 2003-12

Locations

US(1)