NCT00005681

Brief Summary

To test the hypothesis that the aggressive treatment of plasma LDL and oxidized LDL will result in improvements in the activity of ischemia in patients with coronary artery disease and will reverse characteristic cell/vessel wall dysfunctions in the arteries of these patients.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Aug 1989

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 1989

Completed
10.8 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2001

Completed
Last Updated

March 16, 2016

Status Verified

October 1, 2005

First QC Date

May 25, 2000

Last Update Submit

March 15, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary Disease

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (7)

  • Anderson TJ, Gerhard MD, Meredith IT, Charbonneau F, Delagrange D, Creager MA, Selwyn AP, Ganz P. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol. 1995 Feb 23;75(6):71B-74B. doi: 10.1016/0002-9149(95)80017-m.

    PMID: 7863979BACKGROUND

  • Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med. 1995 Feb 23;332(8):488-93. doi: 10.1056/NEJM199502233320802.

    PMID: 7830729BACKGROUND

  • Lieberman EH, Gerhard MD, Uehata A, Walsh BW, Selwyn AP, Ganz P, Yeung AC, Creager MA. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med. 1994 Dec 15;121(12):936-41. doi: 10.7326/0003-4819-121-12-199412150-00005.

    PMID: 7978718BACKGROUND

  • Anderson TJ, Meredith IT, Ganz P, Selwyn AP, Yeung AC. Nitric oxide and nitrovasodilators: similarities, differences and potential interactions. J Am Coll Cardiol. 1994 Aug;24(2):555-66. doi: 10.1016/0735-1097(94)90316-6.

    PMID: 8034895BACKGROUND

  • Anderson TJ, Meredith IT, Selwyn AP, Raby KE. Myocardial revascularization before repair of an aortic aneurysm. Mayo Clin Proc. 1993 Jul;68(7):713-5. doi: 10.1016/s0025-6196(12)60612-0. No abstract available.

    PMID: 8350648BACKGROUND

  • Anderson TJ, Meredith IT, Charbonneau F, Yeung AC, Frei B, Selwyn AP, Ganz P. Endothelium-dependent coronary vasomotion relates to the susceptibility of LDL to oxidation in humans. Circulation. 1996 May 1;93(9):1647-50. doi: 10.1161/01.cir.93.9.1647.

    PMID: 8653869BACKGROUND

  • Stone PH, Lloyd-Jones DM, Johnstone M, Carlson W, Rubenstein J, Creager M, Frei B, Sopko G, Clark ME, Maccallum G, Kinlay S, Orav J, Selwyn AP. Vascular basis for the treatment of myocardial ischemia study: trial design and baseline characteristics. Am Heart J. 2004 May;147(5):875-82. doi: 10.1016/j.ahj.2003.10.046.

    PMID: 15131545BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary Disease

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular Diseases

Study Officials

  • Peter Stone

    Brigham and Women's Hospital

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

August 1, 1989

Study Completion

July 1, 2001

Last Updated

March 16, 2016

Record last verified: 2005-10