NCT00005209

Brief Summary

To relate observations at the DNA level to the distribution of coronary heart disease in the population at large.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Aug 1987

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 1987

Completed
12.8 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
7.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2007

Completed
Last Updated

July 29, 2016

Status Verified

January 1, 2008

Enrollment Period

19.9 years

First QC Date

May 25, 2000

Last Update Submit

July 28, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary Disease

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (54)

  • Pairitz G, Davignon J, Mailloux H, Sing CF. Sources of interindividual variation in the quantitative levels of apolipoprotein B in pedigrees ascertained through a lipid clinic. Am J Hum Genet. 1988 Sep;43(3):311-21.

    PMID: 3414686BACKGROUND

  • Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988 Jan-Feb;8(1):1-21. doi: 10.1161/01.atv.8.1.1.

    PMID: 3277611BACKGROUND

  • Templeton AR, Sing CF, Kessling A, Humphries S. A cladistic analysis of phenotype associations with haplotypes inferred from restriction endonuclease mapping. II. The analysis of natural populations. Genetics. 1988 Dec;120(4):1145-54. doi: 10.1093/genetics/120.4.1145.

    PMID: 3147219BACKGROUND

  • Kaprio J, Ferrell RE, Kottke BA, Sing CF. Smoking and reverse cholesterol transport: evidence for gene-environment interaction. Clin Genet. 1989 Oct;36(4):266-8. doi: 10.1111/j.1399-0004.1989.tb03201.x. No abstract available.

    PMID: 2509115BACKGROUND

  • Reilly SL, Kottke BA, Sing CF. The effects of generation and gender on the joint distributions of lipid and apolipoprotein phenotypes in the population at large. J Clin Epidemiol. 1990;43(9):921-40. doi: 10.1016/0895-4356(90)90076-2.

    PMID: 2213081BACKGROUND

  • Kottke BA, Friedlaender JS, Zerba KE, Sing CF. Lipid and apolipoprotein levels in six Solomon Island societies differ from those in a U.S. white population. Am J Phys Anthropol. 1990 Apr;81(4):483-91. doi: 10.1002/ajpa.1330810405.

    PMID: 2110417BACKGROUND

  • Sing CF, Haviland MB, Zerba KE, Templeton AR. Application of cladistics to the analysis of genotype-phenotype relationships. Eur J Epidemiol. 1992 May;8 Suppl 1:3-9. doi: 10.1007/BF00145343.

    PMID: 1354623BACKGROUND

  • Sing CF, Haviland MB, Templeton AR, Zerba KE, Reilly SL. Biological complexity and strategies for finding DNA variations responsible for inter-individual variation in risk of a common chronic disease, coronary artery disease. Ann Med. 1992 Dec;24(6):539-47. doi: 10.3109/07853899209167008.

    PMID: 1485951BACKGROUND

  • Reilly SL, Ferrell RE, Kottke BA, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet. 1992 Dec;51(6):1311-24.

    PMID: 1463013BACKGROUND

  • Haviland MB, Kessling AM, Davignon J, Sing CF. Estimation of Hardy-Weinberg and pairwise disequilibrium in the apolipoprotein AI-CIII-AIV gene cluster. Am J Hum Genet. 1991 Aug;49(2):350-65.

    PMID: 1678249BACKGROUND

  • Reilly SL, Ferrell RE, Kottke BA, Kamboh MI, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances. Am J Hum Genet. 1991 Dec;49(6):1155-66.

    PMID: 1842218BACKGROUND

  • Kamboh MI, Ferrell RE, Kottke BA. Expressed hypervariable polymorphism of apolipoprotein (a). Am J Hum Genet. 1991 Nov;49(5):1063-74.

    PMID: 1928089BACKGROUND

  • Crews DE, Kamboh MI, Bindon JR, Ferrell RE. Genetic studies of human apolipoproteins. XVII: Population genetics of apolipoprotein polymorphisms in American Samoa. Am J Phys Anthropol. 1991 Feb;84(2):165-70. doi: 10.1002/ajpa.1330840206.

    PMID: 2021192BACKGROUND

  • Kamboh MI, Weiss KM, Ferrell RE. Genetic studies of human apolipoproteins. XVI. APOE polymorphism and cholesterol levels in the Mayans of the Yucatan Peninsula, Mexico. Clin Genet. 1991 Jan;39(1):26-32. doi: 10.1111/j.1399-0004.1991.tb02981.x.

    PMID: 1997212BACKGROUND

  • Kamboh MI, Ferrell RE. Genetic studies of human apolipoproteins. XV. An overview of IEF immunoblotting methods to screen apolipoprotein polymorphisms. Hum Hered. 1990;40(4):193-207. doi: 10.1159/000153931.

    PMID: 2199367BACKGROUND

  • Kwon JM, Boehnke M, Burns TL, Moll PP. Commingling and segregation analyses: comparison of results from a simulation study of a quantitative trait. Genet Epidemiol. 1990;7(1):57-68. doi: 10.1002/gepi.1370070113.

    PMID: 2184092BACKGROUND

  • Ferrell RE, Kamboh MI, Majumder PP, Valdez R, Weiss KM. Genetic studies of human apolipoproteins. XIII. Quantitative polymorphism of apolipoprotein C-III in the Mayans of the Yucatan Peninsula. Hum Hered. 1990;40(3):127-35. doi: 10.1159/000153919.

    PMID: 2365371BACKGROUND

  • Kamboh MI, Kelly LJ, Ferrell RE. Genetic studies of human apolipoproteins: XIV. A simple agarose isoelectric focusing gel method for apolipoprotein E phenotyping. Electrophoresis. 1990 Apr;11(4):314-8. doi: 10.1002/elps.1150110408.

    PMID: 2340826BACKGROUND

  • Zerba KE, Friedlaender JS, Sing CF. Heterogeneity of the blood pressure distribution among Solomon Islands societies with increasing acculturation. Am J Phys Anthropol. 1990 Apr;81(4):493-511. doi: 10.1002/ajpa.1330810406.

    PMID: 2333938BACKGROUND

  • Ferrell RE, Sepehrnia B, Kamboh MI, VandeBerg JL. Highly polymorphic apolipoprotein A-IV locus in the baboon. J Lipid Res. 1990 Jan;31(1):131-5.

    PMID: 2313197BACKGROUND

  • Templeton AR, Crandall KA, Sing CF. A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA sequence data. III. Cladogram estimation. Genetics. 1992 Oct;132(2):619-33. doi: 10.1093/genetics/132.2.619.

    PMID: 1385266BACKGROUND

  • Stengard JH, Zerba KE, Pekkanen J, Ehnholm C, Nissinen A, Sing CF. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation. 1995 Jan 15;91(2):265-9. doi: 10.1161/01.cir.91.2.265.

    PMID: 7805227BACKGROUND

  • Reilly SL, Ferrell RE, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances. Am J Hum Genet. 1994 Nov;55(5):1001-18.

    PMID: 7977338BACKGROUND

  • Rastogi A, Bren ND, Hallaway BJ, Kottke BA. Immunomagnetic separation of subpopulations of apolipoprotein A-I. Mayo Clin Proc. 1994 Feb;69(2):137-43. doi: 10.1016/s0025-6196(12)61040-4.

    PMID: 8309265BACKGROUND

  • Pettitt DJ, Moll PP, Knowler WC, Mott DM, Nelson RG, Saad MF, Bennett PH, Kottke BA. Insulinemia in children at low and high risk of NIDDM. Diabetes Care. 1993 Apr;16(4):608-15. doi: 10.2337/diacare.16.4.608.

    PMID: 8462388BACKGROUND

  • Templeton AR, Sing CF. A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. IV. Nested analyses with cladogram uncertainty and recombination. Genetics. 1993 Jun;134(2):659-69. doi: 10.1093/genetics/134.2.659.

    PMID: 8100789BACKGROUND

  • Reilly SL, Sing CF, Savageau MA, Turner ST. Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory. Integr Physiol Behav Sci. 1994 Jan-Mar;29(1):55-73. doi: 10.1007/BF02691281.

    PMID: 8018552BACKGROUND

  • Zerba KE, Ferrell RE, Sing CF. Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human. Genetics. 1996 May;143(1):463-78. doi: 10.1093/genetics/143.1.463.

    PMID: 8722796BACKGROUND

  • Haviland MB, Ferrell RE, Sing CF. Association between common alleles of the low-density lipoprotein receptor gene region and interindividual variation in plasma lipid and apolipoprotein levels in a population-based sample from Rochester, Minnesota. Hum Genet. 1997 Jan;99(1):108-14. doi: 10.1007/s004390050322.

    PMID: 9003506BACKGROUND

  • Moore JH, Reilly SL, Ferrell RE, Sing CF. The role of the apolipoprotein E polymorphism in the prediction of coronary artery disease age of onset. Clin Genet. 1997 Jan;51(1):22-5. doi: 10.1111/j.1399-0004.1997.tb02408.x.

    PMID: 9084929BACKGROUND

  • Stengard JH, Zerba KE, Turner ST, Sing CF. A biometrical study of the relationship between sodium-lithium countertransport and triglycerides. Ann Hum Genet. 1997 Mar;61(Pt 2):121-36. doi: 10.1046/j.1469-1809.1997.6120121.x.

    PMID: 9177119BACKGROUND

  • Kardia SL, Sing CF, Turner ST. The response of renal plasma flow to angiotensin II infusion in a population-based sample and its association with the parental history of essential hypertension. J Hypertens. 1997 May;15(5):483-93. doi: 10.1097/00004872-199715050-00003.

    PMID: 9170000BACKGROUND

  • Stengard JH, Pekkanen J, Sulkava R, Ehnholm C, Erkinjuntti T, Nissinen A. Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. Acta Neurol Scand. 1995 Oct;92(4):297-8. doi: 10.1111/j.1600-0404.1995.tb00132.x.

    PMID: 8848934BACKGROUND

  • Kardia SL, Haviland MB, Sing CF. Correlates of family history of coronary artery disease in children. J Clin Epidemiol. 1998 Jun;51(6):473-86. doi: 10.1016/s0895-4356(98)00008-0.

    PMID: 9635996BACKGROUND

  • Nelson MR, Kardia SL, Ferrell RE, Sing CF. Influence of apolipoprotein E genotype variation on the means, variances, and correlations of plasma lipids and apolipoproteins in children. Ann Hum Genet. 1999 Jul;63(Pt 4):311-28. doi: 10.1046/j.1469-1809.1999.6340311.x.

    PMID: 10738543BACKGROUND

  • Schwartz GL, Turner ST, Moore JH, Sing CF. Predictors of interindividual variation in ambulatory blood pressure and their time or activity dependence. Am J Hypertens. 2000 Jan;13(1 Pt 1):52-60. doi: 10.1016/s0895-7061(99)00127-2.

    PMID: 10678271BACKGROUND

  • Kardia SL, Haviland MB, Ferrell RE, Sing CF. The relationship between risk factor levels and presence of coronary artery calcification is dependent on apolipoprotein E genotype. Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):427-35. doi: 10.1161/01.atv.19.2.427.

    PMID: 9974428BACKGROUND

  • Zerba KE, Ferrell RE, Sing CF. Genetic structure of five susceptibility gene regions for coronary artery disease: disequilibria within and among regions. Hum Genet. 1998 Sep;103(3):346-54. doi: 10.1007/s004390050828.

    PMID: 9799092BACKGROUND

  • Clark AG, Weiss KM, Nickerson DA, Taylor SL, Buchanan A, Stengard J, Salomaa V, Vartiainen E, Perola M, Boerwinkle E, Sing CF. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet. 1998 Aug;63(2):595-612. doi: 10.1086/301977.

    PMID: 9683608BACKGROUND

  • Templeton AR, Weiss KM, Nickerson DA, Boerwinkle E, Sing CF. Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies. Genetics. 2000 Nov;156(3):1259-75. doi: 10.1093/genetics/156.3.1259.

    PMID: 11063700BACKGROUND

  • Fullerton SM, Clark AG, Weiss KM, Nickerson DA, Taylor SL, Stengard JH, Salomaa V, Vartiainen E, Perola M, Boerwinkle E, Sing CF. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet. 2000 Oct;67(4):881-900. doi: 10.1086/303070. Epub 2000 Sep 13.

    PMID: 10986041BACKGROUND

  • Nelson MR, Kardia SL, Ferrell RE, Sing CF. A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. Genome Res. 2001 Mar;11(3):458-70. doi: 10.1101/gr.172901.

    PMID: 11230170BACKGROUND

  • Fullerton SM, Clark AG, Weiss KM, Taylor SL, Stengard JH, Salomaa V, Boerwinkle E, Nickerson DA. Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sample. Hum Genet. 2002 Jul;111(1):75-87. doi: 10.1007/s00439-002-0763-x. Epub 2002 Jun 14.

    PMID: 12136239BACKGROUND

  • Wilund KR, Ferrell RE, Phares DA, Goldberg AP, Hagberg JM. Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotype. Metabolism. 2002 Jun;51(6):774-8. doi: 10.1053/meta.2002.32730.

    PMID: 12037734BACKGROUND

  • Hagberg JM, Zmuda JM, McCole SD, Rodgers KS, Ferrell RE, Wilund KR, Moore GE. Moderate physical activity is associated with higher bone mineral density in postmenopausal women. J Am Geriatr Soc. 2001 Nov;49(11):1411-7. doi: 10.1046/j.1532-5415.2001.4911231.x.

    PMID: 11890577BACKGROUND

  • Stengard JH, Clark AG, Weiss KM, Kardia S, Nickerson DA, Salomaa V, Ehnholm C, Boerwinkle E, Sing CF. Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Am J Hum Genet. 2002 Sep;71(3):501-17. doi: 10.1086/342217. Epub 2002 Aug 5.

    PMID: 12165926BACKGROUND

  • Sing CF, Stengard JH, Kardia SL. Genes, environment, and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1190-6. doi: 10.1161/01.ATV.0000075081.51227.86. Epub 2003 May 1.

    PMID: 12730090BACKGROUND

  • Fullerton SM, Buchanan AV, Sonpar VA, Taylor SL, Smith JD, Carlson CS, Salomaa V, Stengard JH, Boerwinkle E, Clark AG, Nickerson DA, Weiss KM. The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. Hum Genet. 2004 Jun;115(1):36-56. doi: 10.1007/s00439-004-1106-x. Epub 2004 Apr 24.

    PMID: 15108119BACKGROUND

  • Klos KL, Kardia SL, Hixson JE, Turner ST, Hanis C, Boerwinkle E, Sing CF. Linkage analysis of plasma ApoE in three ethnic groups: multiple genes with context-dependent effects. Ann Hum Genet. 2005 Mar;69(Pt 2):157-67. doi: 10.1046/j.1529-8817.2004.00148.x.

    PMID: 15720297BACKGROUND

  • Klos KL, Hamon S, Clark AG, Boerwinkle E, Liu K, Sing CF. APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study. J Lipid Res. 2005 Mar;46(3):564-71. doi: 10.1194/jlr.M400437-JLR200. Epub 2004 Dec 16.

    PMID: 15604515BACKGROUND

  • Kardia SL, Turner ST, Schwartz GL, Moore JH. Linear dynamic features of ambulatory blood pressure in a population-based study. Blood Press Monit. 2004 Oct;9(5):259-67. doi: 10.1097/00126097-200410000-00006.

    PMID: 15472499BACKGROUND

  • Templeton AR, Maxwell T, Posada D, Stengard JH, Boerwinkle E, Sing CF. Tree scanning: a method for using haplotype trees in phenotype/genotype association studies. Genetics. 2005 Jan;169(1):441-53. doi: 10.1534/genetics.104.030080. Epub 2004 Sep 15.

    PMID: 15371364BACKGROUND

  • Neel JV, Julius S, Weder A, Yamada M, Kardia SL, Haviland MB. Syndrome X: is it for real? Genet Epidemiol. 1998;15(1):19-32. doi: 10.1002/(SICI)1098-2272(1998)15:13.0.CO;2-#.

    PMID: 9523208BACKGROUND

  • Sing CF, Moll PP. Genetics of atherosclerosis. Annu Rev Genet. 1990;24:171-87. doi: 10.1146/annurev.ge.24.120190.001131. No abstract available.

    PMID: 2088166BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary Disease

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular Diseases

Study Officials

  • Charles Sing

    University of Michigan

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

August 1, 1987

Primary Completion

July 1, 2007

Study Completion

July 1, 2007

Last Updated

July 29, 2016

Record last verified: 2008-01