NCT00005562

Brief Summary

To investigate coronary artery calcium (CAC), detected by electron beam computed tomography (EBCT), as a predictor of coronary heart disease (CHD) mortality and morbidity, stroke, and all-cause mortality in a historical cohort epidemiological study.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1999

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1999

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
6.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2006

Completed
Last Updated

March 13, 2014

Status Verified

March 1, 2014

Enrollment Period

6.9 years

First QC Date

May 25, 2000

Last Update Submit

March 12, 2014

Conditions

Cardiovascular DiseasesCoronary DiseaseCerebrovascular DisordersHeart DiseasesCerebrovascular Accident

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (14)

  • Wei M, Schwertner HA, Blair SN. The association between physical activity, physical fitness, and type 2 diabetes mellitus. Compr Ther. 2000 Fall;26(3):176-82. doi: 10.1007/s12019-000-0006-9.

    PMID: 10984822BACKGROUND

  • Wei M, Gibbons LW, Mitchell TL, Kampert JB, Blair SN. Alcohol intake and incidence of type 2 diabetes in men. Diabetes Care. 2000 Jan;23(1):18-22. doi: 10.2337/diacare.23.1.18.

    PMID: 10857962BACKGROUND

  • Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med. 2000 Apr 18;132(8):605-11. doi: 10.7326/0003-4819-132-8-200004180-00002.

    PMID: 10766678BACKGROUND

  • Blair SN, Nichaman MZ. The public health problem of increasing prevalence rates of obesity and what should be done about it. Mayo Clin Proc. 2002 Feb;77(2):109-13. doi: 10.4065/77.2.109. No abstract available.

    PMID: 11838643BACKGROUND

  • Nguyen-Duy TB, Nichaman MZ, Church TS, Blair SN, Ross R. Visceral fat and liver fat are independent predictors of metabolic risk factors in men. Am J Physiol Endocrinol Metab. 2003 Jun;284(6):E1065-71. doi: 10.1152/ajpendo.00442.2002. Epub 2003 Jan 28.

    PMID: 12554597BACKGROUND

  • Cheng YJ, Church TS, Kimball TE, Nichaman MZ, Levine BD, McGuire DK, Blair SN. Comparison of coronary artery calcium detected by electron beam tomography in patients with to those without symptomatic coronary heart disease. Am J Cardiol. 2003 Sep 1;92(5):498-503. doi: 10.1016/s0002-9149(03)00714-8.

    PMID: 12943866BACKGROUND

  • Blair SN, LaMonte MJ, Nichaman MZ. The evolution of physical activity recommendations: how much is enough? Am J Clin Nutr. 2004 May;79(5):913S-920S. doi: 10.1093/ajcn/79.5.913S.

    PMID: 15113739BACKGROUND

  • Wong SL, Katzmarzyk P, Nichaman MZ, Church TS, Blair SN, Ross R. Cardiorespiratory fitness is associated with lower abdominal fat independent of body mass index. Med Sci Sports Exerc. 2004 Feb;36(2):286-91. doi: 10.1249/01.MSS.0000113665.40775.35.

    PMID: 14767252BACKGROUND

  • Kuk JL, Nichaman MZ, Church TS, Blair SN, Ross R. Liver fat is not a marker of metabolic risk in lean premenopausal women. Metabolism. 2004 Aug;53(8):1066-71. doi: 10.1016/j.metabol.2004.02.016.

    PMID: 15281020BACKGROUND

  • Lee S, Janssen I, Ross R. Interindividual variation in abdominal subcutaneous and visceral adipose tissue: influence of measurement site. J Appl Physiol (1985). 2004 Sep;97(3):948-54. doi: 10.1152/japplphysiol.01200.2003. Epub 2004 Apr 30.

    PMID: 15121737BACKGROUND

  • LaMonte MJ, FitzGerald SJ, Church TS, Barlow CE, Radford NB, Levine BD, Pippin JJ, Gibbons LW, Blair SN, Nichaman MZ. Coronary artery calcium score and coronary heart disease events in a large cohort of asymptomatic men and women. Am J Epidemiol. 2005 Sep 1;162(5):421-9. doi: 10.1093/aje/kwi228. Epub 2005 Aug 2.

    PMID: 16076829BACKGROUND

  • Barlow CE, LaMonte MJ, Fitzgerald SJ, Kampert JB, Perrin JL, Blair SN. Cardiorespiratory fitness is an independent predictor of hypertension incidence among initially normotensive healthy women. Am J Epidemiol. 2006 Jan 15;163(2):142-50. doi: 10.1093/aje/kwj019. Epub 2005 Nov 17.

    PMID: 16293717BACKGROUND

  • Jurca R, Lamonte MJ, Barlow CE, Kampert JB, Church TS, Blair SN. Association of muscular strength with incidence of metabolic syndrome in men. Med Sci Sports Exerc. 2005 Nov;37(11):1849-55. doi: 10.1249/01.mss.0000175865.17614.74.

    PMID: 16286852BACKGROUND

  • LaMonte MJ, Barlow CE, Jurca R, Kampert JB, Church TS, Blair SN. Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome: a prospective study of men and women. Circulation. 2005 Jul 26;112(4):505-12. doi: 10.1161/CIRCULATIONAHA.104.503805. Epub 2005 Jul 11.

    PMID: 16009797BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary DiseaseCerebrovascular DisordersHeart DiseasesStroke

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Officials

  • Michael Lamonte

    Cooper Institute for Aerobics Research

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1999

Primary Completion

August 1, 2006

Study Completion

August 1, 2006

Last Updated

March 13, 2014

Record last verified: 2014-03