Dietary Patterns and Risk of Cardiovascular Disease
2 other identifiers
observational
120,000
0 countries
N/A
Brief Summary
To study, prospectively, the association between dietary patterns and risk of coronary heart disease (CHD), ischemic stroke, and hemorrhagic stroke in cohort studies of 121,700 women age 30 to 55 years at baseline in 1976 (the Nurses; Health Study; NHS) and 51,529 men aged 40-75 years at baseline in 1986 (the Health Professionals Follow-up Study; HPFS).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 1998
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 1998
CompletedFirst Submitted
Initial submission to the registry
May 25, 2000
CompletedFirst Posted
Study publicly available on registry
May 26, 2000
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2009
CompletedMarch 20, 2013
March 1, 2013
10.4 years
May 25, 2000
March 18, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Incident cardiovascular disease
Myocardial infarction, fatal coronary disease, and stroke documented by medical records
1980-2008
Eligibility Criteria
Nurses' Health Study and Health Professionals' Follow-up Study
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Related Publications (15)
Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr. 2000 Oct;72(4):912-21. doi: 10.1093/ajcn/72.4.912.
PMID: 11010931BACKGROUNDHu FB, Stampfer MJ, Manson JE, Grodstein F, Colditz GA, Speizer FE, Willett WC. Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N Engl J Med. 2000 Aug 24;343(8):530-7. doi: 10.1056/NEJM200008243430802.
PMID: 10954760BACKGROUNDDigranes A, Hardardottir H, Bottolfsen KL. Temafloxacin: in vitro comparison with five other antibacterial agents. Chemotherapy. 1991;37(2):98-105. doi: 10.1159/000238840.
PMID: 2032475BACKGROUNDHu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A, Sampson L, Willett WC. Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr. 1999 Feb;69(2):243-9. doi: 10.1093/ajcn/69.2.243.
PMID: 9989687BACKGROUNDMcCullough ML, Feskanich D, Stampfer MJ, Rosner BA, Hu FB, Hunter DJ, Variyam JN, Colditz GA, Willett WC. Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in women. Am J Clin Nutr. 2000 Nov;72(5):1214-22. doi: 10.1093/ajcn/72.5.1214.
PMID: 11063452BACKGROUNDFung TT, Rimm EB, Spiegelman D, Rifai N, Tofler GH, Willett WC, Hu FB. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am J Clin Nutr. 2001 Jan;73(1):61-7. doi: 10.1093/ajcn/73.1.61.
PMID: 11124751BACKGROUNDFung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB. Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med. 2001 Aug 13-27;161(15):1857-62. doi: 10.1001/archinte.161.15.1857.
PMID: 11493127BACKGROUNDHu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA. 2002 Nov 27;288(20):2569-78. doi: 10.1001/jama.288.20.2569.
PMID: 12444864BACKGROUNDOsganian SK, Stampfer MJ, Rimm E, Spiegelman D, Manson JE, Willett WC. Dietary carotenoids and risk of coronary artery disease in women. Am J Clin Nutr. 2003 Jun;77(6):1390-9. doi: 10.1093/ajcn/77.6.1390.
PMID: 12791615BACKGROUNDHu FB. Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr. 2003 Sep;78(3 Suppl):544S-551S. doi: 10.1093/ajcn/78.3.544S.
PMID: 12936948BACKGROUNDOsganian SK, Stampfer MJ, Rimm E, Spiegelman D, Hu FB, Manson JE, Willett WC. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol. 2003 Jul 16;42(2):246-52. doi: 10.1016/s0735-1097(03)00575-8.
PMID: 12875759BACKGROUNDHalton TL, Hu FB. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr. 2004 Oct;23(5):373-85. doi: 10.1080/07315724.2004.10719381.
PMID: 15466943BACKGROUNDFung TT, Stampfer MJ, Manson JE, Rexrode KM, Willett WC, Hu FB. Prospective study of major dietary patterns and stroke risk in women. Stroke. 2004 Sep;35(9):2014-9. doi: 10.1161/01.STR.0000135762.89154.92. Epub 2004 Jul 1.
PMID: 15232120BACKGROUNDSchulze MB, Hoffmann K, Manson JE, Willett WC, Meigs JB, Weikert C, Heidemann C, Colditz GA, Hu FB. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr. 2005 Sep;82(3):675-84; quiz 714-5. doi: 10.1093/ajcn.82.3.675.
PMID: 16155283BACKGROUNDHu FB. Protein, body weight, and cardiovascular health. Am J Clin Nutr. 2005 Jul;82(1 Suppl):242S-247S. doi: 10.1093/ajcn/82.1.242S.
PMID: 16002829BACKGROUND
Biospecimen
Plasma and buffy coat
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
August 1, 1998
Primary Completion
January 1, 2009
Study Completion
January 1, 2009
Last Updated
March 20, 2013
Record last verified: 2013-03