CHD Risk, Behavioral Stress and Reproductive Hormones

NCT00005538 | Completed

• 2 other identifiers: 5075R37HL038712
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine the effects of behavioral stress and reproductive hormones on coronary heart disease (CHD) risk.

Conditions

Cardiovascular Diseases; Coronary Disease; Heart Diseases; Menopause

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (24)

• Raikkonen K, Matthews KA, Flory JD, Owens JF, Gump BB. Effects of optimism, pessimism, and trait anxiety on ambulatory blood pressure and mood during everyday life. J Pers Soc Psychol. 1999 Jan;76(1):104-13. doi: 10.1037//0022-3514.76.1.104.

  PMID: 9972556 BACKGROUND

• Raikkonen K, Matthews KA, Flory JD, Owens JF. Effects of hostility on ambulatory blood pressure and mood during daily living in healthy adults. Health Psychol. 1999 Jan;18(1):44-53. doi: 10.1037//0278-6133.18.1.44.

  PMID: 9925045 BACKGROUND

• Matthews KA, Berga SL, Owens JF, Flory JD. Effects of short-term suppression of ovarian hormones on cardiovascular and neuroendocrine reactivity to stress in women. Psychoneuroendocrinology. 1998 May;23(4):307-22. doi: 10.1016/s0306-4530(98)00013-4.

  PMID: 9695133 BACKGROUND

• Davis MC, Matthews KA. Do gender-relevant characteristics determine cardiovascular reactivity? Match versus mismatch of traits and situation. J Pers Soc Psychol. 1996 Sep;71(3):527-35. doi: 10.1037//0022-3514.71.3.527.

  PMID: 8831160 BACKGROUND

• Matthews KA, Caggiula AR, McAllister CG, Berga SL, Owens JF, Flory JD, Miller AL. Sympathetic reactivity to acute stress and immune response in women. Psychosom Med. 1995 Nov-Dec;57(6):564-71. doi: 10.1097/00006842-199511000-00009.

  PMID: 8600483 BACKGROUND

• Stoney CM, Owens JF, Guzick DS, Matthews KA. A natural experiment on the effects of ovarian hormones on cardiovascular risk factors and stress reactivity: bilateral salpingo oophorectomy versus hysterectomy only. Health Psychol. 1997 Jul;16(4):349-58. doi: 10.1037//0278-6133.16.4.349.

  PMID: 9237087 BACKGROUND

• Patterson SM, Matthews KA, Allen MT, Owens JF. Stress-induced hemoconcentration of blood cells and lipids in healthy women during acute psychological stress. Health Psychol. 1995 Jul;14(4):319-24. doi: 10.1037//0278-6133.14.4.319.

  PMID: 7556035 BACKGROUND

• Caggiula AR, McAllister CG, Matthews KA, Berga SL, Owens JF, Miller AL. Psychological stress and immunological responsiveness in normally cycling, follicular-stage women. J Neuroimmunol. 1995 Jun;59(1-2):103-11. doi: 10.1016/0165-5728(95)00031-v.

  PMID: 7797611 BACKGROUND

• Adler N, Matthews K. Health psychology: why do some people get sick and some stay well? Annu Rev Psychol. 1994;45:229-59. doi: 10.1146/annurev.ps.45.020194.001305. No abstract available.

  PMID: 8135503 BACKGROUND

• Owens JF, Stoney CM, Matthews KA. Menopausal status influences ambulatory blood pressure levels and blood pressure changes during mental stress. Circulation. 1993 Dec;88(6):2794-802. doi: 10.1161/01.cir.88.6.2794.

  PMID: 8252693 BACKGROUND

• Allen MT, Stoney CM, Owens JF, Matthews KA. Hemodynamic adjustments to laboratory stress: the influence of gender and personality. Psychosom Med. 1993 Nov-Dec;55(6):505-17. doi: 10.1097/00006842-199311000-00006.

  PMID: 8310111 BACKGROUND

• Matthews KA, Owens JF, Allen MT, Stoney CM. Do cardiovascular responses to laboratory stress relate to ambulatory blood pressure levels?: Yes, in some of the people, some of the time. Psychosom Med. 1992 Nov-Dec;54(6):686-97. doi: 10.1097/00006842-199211000-00009.

  PMID: 1454963 BACKGROUND

• Matthews KA, Rodin J. Pregnancy alters blood pressure responses to psychological and physical challenge. Psychophysiology. 1992 Mar;29(2):232-40. doi: 10.1111/j.1469-8986.1992.tb01691.x.

  PMID: 1635966 BACKGROUND

• Matthews KA. Myths and realities of the menopause. Psychosom Med. 1992 Jan-Feb;54(1):1-9. doi: 10.1097/00006842-199201000-00001.

  PMID: 1553395 BACKGROUND

• Matthews KA, Davis MC, Stoney CM, Owens JF, Caggiula AR. Does the gender relevance of the stressor influence sex differences in psychophysiological responses? Health Psychol. 1991;10(2):112-20. doi: 10.1037//0278-6133.10.2.112.

  PMID: 2055209 BACKGROUND

• Caggiula AR, Stoney CM, Matthews KA, Owens JF, Davis MC, Rabin BS. T-lymphocyte reactivity during the menstrual cycle in women. Clin Immunol Immunopathol. 1990 Jul;56(1):130-4. doi: 10.1016/0090-1229(90)90177-r.

  PMID: 2113445 BACKGROUND

• Stoney CM, Owens JF, Matthews KA, Davis MC, Caggiula A. Influences of the normal menstrual cycle on physiologic functioning during behavioral stress. Psychophysiology. 1990 Mar;27(2):125-35. doi: 10.1111/j.1469-8986.1990.tb00364.x.

  PMID: 2247544 BACKGROUND

• Davis MC, Matthews KA. Cigarette smoking and oral contraceptive use influence women's lipid, lipoprotein, and cardiovascular responses during stress. Health Psychol. 1990;9(6):717-36. doi: 10.1037//0278-6133.9.6.717.

  PMID: 2286182 BACKGROUND

• Saab PG, Matthews KA, Stoney CM, McDonald RH. Premenopausal and postmenopausal women differ in their cardiovascular and neuroendocrine responses to behavioral stressors. Psychophysiology. 1989 May;26(3):270-80. doi: 10.1111/j.1469-8986.1989.tb01917.x.

  PMID: 2756076 BACKGROUND

• Matthews KA, Raikkonen K, Everson SA, Flory JD, Marco CA, Owens JF, Lloyd CE. Do the daily experiences of healthy men and women vary according to occupational prestige and work strain? Psychosom Med. 2000 May-Jun;62(3):346-53. doi: 10.1097/00006842-200005000-00008.

  PMID: 10845348 BACKGROUND

• Matthews KA, Gump BB, Owens JF. Chronic stress influences cardiovascular and neuroendocrine responses during acute stress and recovery, especially in men. Health Psychol. 2001 Nov;20(6):403-10.

  PMID: 11714181 BACKGROUND

• Powers RW, Majors AK, Lykins DL, Sims CJ, Lain KY, Roberts JM. Plasma homocysteine and malondialdehyde are correlated in an age- and gender-specific manner. Metabolism. 2002 Nov;51(11):1433-8. doi: 10.1053/meta.2002.35587.

  PMID: 12404194 BACKGROUND

• Flory JD, Matthews KA, Sistilli CG, Caggiula AR, Berga SL, Owens JF. Short-term suppression of ovarian function and immune measures in healthy women. Psychoneuroendocrinology. 2002 Aug;27(6):749-68. doi: 10.1016/s0306-4530(01)00078-6.

  PMID: 12084666 BACKGROUND

• Owens JF, Matthews KA, Everson SA. Cognitive function effects of suppressing ovarian hormones in young women. Menopause. 2002 Jul-Aug;9(4):227-35. doi: 10.1097/00042192-200207000-00003.

  PMID: 12082358 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Coronary Disease; Heart Diseases

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Vascular Diseases

Study Officials

• Karen Matthews

  University of Pittsburgh

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: July 1, 1987
• Study Completion: June 1, 2000
• Last Updated: May 13, 2016

Record last verified: 2004-08