NCT00005304

Brief Summary

To determine the prevalence of hepatitis delta virus (HDV) in a large cohort of hemophiliacs and to elucidate the role of HDV in the development and progression of liver disease in this population.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1986

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1986

Completed
5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 1991

Completed
8.7 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

April 7, 2020

Status Verified

April 1, 2020

First QC Date

May 25, 2000

Last Update Submit

April 3, 2020

Conditions

Blood DiseaseHepatitis, Viral, HumanHemophilia ALiver Diseases

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (6)

  • Garnier G, Ault B, Kramer M, Colten HR. cis and trans elements differ among mouse strains with high and low extrahepatic complement factor B gene expression. J Exp Med. 1992 Feb 1;175(2):471-9. doi: 10.1084/jem.175.2.471.

    PMID: 1370685BACKGROUND

  • Haviland DL, Haviland JC, Fleischer DT, Wetsel RA. Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes. J Biol Chem. 1991 Jun 25;266(18):11818-25.

    PMID: 1711041BACKGROUND

  • Haviland DL, Haviland JC, Fleischer DT, Hunt A, Wetsel RA. Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene. J Immunol. 1991 Jan 1;146(1):362-8.

    PMID: 1984448BACKGROUND

  • Wetsel RA, Fleischer DT, Haviland DL. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem. 1990 Feb 15;265(5):2435-40.

    PMID: 2303408BACKGROUND

  • Haviland DL, Borel AC, Fleischer DT, Haviland JC, Wetsel RA. Structure, 5'-flanking sequence, and chromosome location of the human N-formyl peptide receptor gene. A single-copy gene comprised of two exons on chromosome 19q.13.3 that yields two distinct transcripts by alternative polyadenylation. Biochemistry. 1993 Apr 27;32(16):4168-74. doi: 10.1021/bi00067a003.

    PMID: 7682842BACKGROUND

  • Troisi CL, Hollinger FB, Hoots WK, Contant C, Gill J, Ragni M, Parmley R, Sexauer C, Gomperts E, Buchanan G, et al. A multicenter study of viral hepatitis in a United States hemophilic population. Blood. 1993 Jan 15;81(2):412-8.

    PMID: 7678517BACKGROUND

MeSH Terms

Conditions

Hematologic DiseasesHepatitis, Viral, HumanHemophilia ALiver Diseases

Condition Hierarchy (Ancestors)

Hemic and Lymphatic DiseasesVirus DiseasesInfectionsHepatitisDigestive System DiseasesBlood Coagulation Disorders, InheritedBlood Coagulation DisordersCoagulation Protein DisordersHemorrhagic DisordersGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

Study Type
observational
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, Virology & Microbiology

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1986

Study Completion

September 1, 1991

Last Updated

April 7, 2020

Record last verified: 2020-04