Natural History of Post-transfusion Non-A, Non-B Hepatitis

NCT00005306 | Completed

• 1 other identifier: 3007
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare the clinical, biochemical, and histological status of Non-A, Non-B post-transfusion hepatitis patients with that of patients who did not develop post-transfusion hepatitis.

Conditions

Hepatitis, Viral, Human; Blood Transfusion; Liver Diseases

Eligibility Criteria

• Age: Up to 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (10)

• Seeff LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter HJ, Iber FL, Hollinger FB, Gitnick G, Knodell RG, Perrillo RP, et al. Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. N Engl J Med. 1992 Dec 31;327(27):1906-11. doi: 10.1056/NEJM199212313272703.

  PMID: 1454085 BACKGROUND

• Duffy LF, Kerzner B, Seeff L, Barr SB, Soldin SJ. Preliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver function. Clin Biochem. 1995 Oct;28(5):527-30. doi: 10.1016/0009-9120(95)00036-9.

  PMID: 8582052 BACKGROUND

• Koff RS, Seeff LB. Economic modeling of treatment in chronic hepatitis B and chronic hepatitis C: promises and limitations. Hepatology. 1995 Dec;22(6):1880-2. No abstract available.

  PMID: 7490001 BACKGROUND

• Tedeschi V, Seeff LB. Diagnostic tests for hepatitis C: where are we now? Ann Intern Med. 1995 Sep 1;123(5):383-5. doi: 10.7326/0003-4819-123-5-199509010-00009. No abstract available.

  PMID: 7625627 BACKGROUND

• Seeff LB. Natural history of viral hepatitis, type C. Semin Gastrointest Dis. 1995 Jan;6(1):20-7. No abstract available.

  PMID: 7894963 BACKGROUND

• Seeff LB, Alter HJ. Spousal transmission of the hepatitis C virus? Ann Intern Med. 1994 May 1;120(9):807-9. doi: 10.7326/0003-4819-120-9-199405010-00014. No abstract available.

  PMID: 8147555 BACKGROUND

• Norman JE, Beebe GW, Hoofnagle JH, Seeff LB. Mortality follow-up of the 1942 epidemic of hepatitis B in the U.S. Army. Hepatology. 1993 Oct;18(4):790-7. doi: 10.1002/hep.1840180407.

  PMID: 8406352 BACKGROUND

• Seeff LB, Hollinger FB, Alter HJ, Wright EC, Cain CM, Buskell ZJ, Ishak KG, Iber FL, Toro D, Samanta A, Koretz RL, Perrillo RP, Goodman ZD, Knodell RG, Gitnick G, Morgan TR, Schiff ER, Lasky S, Stevens C, Vlahcevic RZ, Weinshel E, Tanwandee T, Lin HJ, Barbosa L. Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative study. Hepatology. 2001 Feb;33(2):455-63. doi: 10.1053/jhep.2001.21905.

  PMID: 11172349 BACKGROUND

• Lin HJ, Seeff LB, Barbosa L, Hollinger FB. Occurrence of identical hypervariable region 1 sequences of hepatitis C virus in transfusion recipients and their respective blood donors: divergence over time. Hepatology. 2001 Aug;34(2):424-9. doi: 10.1053/jhep.2001.26635.

  PMID: 11481629 BACKGROUND

• Harris DR, Gonin R, Alter HJ, Wright EC, Buskell ZJ, Hollinger FB, Seeff LB; National Heart, Lung, and Blood Institute Study Group. The relationship of acute transfusion-associated hepatitis to the development of cirrhosis in the presence of alcohol abuse. Ann Intern Med. 2001 Jan 16;134(2):120-4. doi: 10.7326/0003-4819-134-2-200101160-00012.

  PMID: 11177315 BACKGROUND

MeSH Terms

Conditions

Hepatitis, Viral, Human; Liver Diseases

Condition Hierarchy (Ancestors)

Virus Diseases; Infections; Hepatitis; Digestive System Diseases

Study Officials

• Leonard Seeff

  Georgetown University

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: March 1, 1988
• Study Completion: September 1, 2001
• Last Updated: April 14, 2016

Record last verified: 2004-08