NCT00005181|Completed
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Sponsor study identifier
Secondary identifiers
NIH
observational
N/A
0 countries
N/A
Study Start
July 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2003
Actual (reported)Study Completion
June 2003
Actual (reported)To correlate dietary factors and changes in pressor substances, including aldosterone and norepinephrine, with blood pressure during growth and sexual development from childhood through adolescence.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2003
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 25, 2000
Actual (reported)May 26, 2000
Actual (reported)July 2000
Date type not reportedThis date has not been verified as actual or estimated.
June 2003
Actual (reported)June 2003
Actual (reported)Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Bloem LJ, Foroud TM, Ambrosius WT, Hanna MP, Tewksbury DA, Pratt JH. Association of the angiotensinogen gene to serum angiotensinogen in blacks and whites. Hypertension. 1997 May;29(5):1078-82. doi: 10.1161/01.hyp.29.5.1078.
Pratt JH, Manatunga AK, Hanna MP, Ambrosius WT. Effect of administered potassium on the renin-aldosterone axis in young blacks compared with whites. J Hypertens. 1997 Aug;15(8):877-83. doi: 10.1097/00004872-199715080-00012.
John Pratt
Indiana University Medical Center
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
July 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2003
Actual (reported)Stepped Intervention for Meds Adherence and Blood Pressure Control
Pratt JH, Jones JJ, Miller JZ, Wagner MA, Fineberg NS. Racial differences in aldosterone excretion and plasma aldosterone concentrations in children. N Engl J Med. 1989 Oct 26;321(17):1152-7. doi: 10.1056/NEJM198910263211703.
Pratt JH, Manatunga AK, Wagner MA, Jones JJ, Meaney FJ. Adrenal androgen excretion during adrenarche. Relation to race and blood pressure. Hypertension. 1990 Oct;16(4):462-7. doi: 10.1161/01.hyp.16.4.462.
Pratt JH, Manatunga AK, Bowsher RR, Henry DP. The interaction of norepinephrine excretion with blood pressure and race in children. J Hypertens. 1992 Jan;10(1):93-6. doi: 10.1097/00004872-199201000-00015.
Manatunga AK, Reister TK, Miller JZ, Pratt JH. Genetic influences on the urinary excretion of aldosterone in children. Hypertension. 1992 Feb;19(2):192-7. doi: 10.1161/01.hyp.19.2.192.
Pratt JH, Rothrock JK, Dominguez JH. Inhibition of aldosterone production by pinacidil in vitro. Hypertension. 1991 Oct;18(4):529-34. doi: 10.1161/01.hyp.18.4.529.
Shackleton CH, Kletke C, Wudy S, Pratt JH. Dehydroepiandrosterone sulfate quantification in serum using high-performance liquid chromatography/mass spectrometry and a deuterated internal standard: a technique suitable for routine use or as a reference method. Steroids. 1990 Oct;55(10):472-8. doi: 10.1016/0039-128x(90)90016-5.
Pratt JH, Manatunga AK, Peacock M. A comparison of the urinary excretion of bone resorptive products in white and black children. J Lab Clin Med. 1996 Jan;127(1):67-70. doi: 10.1016/s0022-2143(96)90167-5.
Bloem LJ, Manatunga AK, Pratt JH. Racial difference in the relationship of an angiotensin I-converting enzyme gene polymorphism to serum angiotensin I-converting enzyme activity. Hypertension. 1996 Jan;27(1):62-6. doi: 10.1161/01.hyp.27.1.62.
Bloem LJ, Guo C, Pratt JH. Identification of a splice variant of the rat and human mineralocorticoid receptor genes. J Steroid Biochem Mol Biol. 1995 Nov;55(2):159-62. doi: 10.1016/0960-0760(95)00162-s.
Bloem LJ, Manatunga AK, Tewksbury DA, Pratt JH. The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. J Clin Invest. 1995 Mar;95(3):948-53. doi: 10.1172/JCI117803.
Pratt JH, Manatunga AK, Li W. Familial influences on the adrenal androgen excretion rate during the adrenarche. Metabolism. 1994 Feb;43(2):186-9. doi: 10.1016/0026-0495(94)90243-7.
Pratt JH, Manatunga AK, Bloem LJ, Li W. Racial differences in aldosterone excretion: a longitudinal study in children. J Clin Endocrinol Metab. 1993 Dec;77(6):1512-5. doi: 10.1210/jcem.77.6.8263135.
Manatunga AK, Jones JJ, Pratt JH. Longitudinal assessment of blood pressures in black and white children. Hypertension. 1993 Jul;22(1):84-9. doi: 10.1161/01.hyp.22.1.84.
Pratt JH, Ambrosius WT, Tewksbury DA, Wagner MA, Zhou L, Hanna MP. Serum angiotensinogen concentration in relation to gonadal hormones, body size, and genotype in growing young people. Hypertension. 1998 Nov;32(5):875-9. doi: 10.1161/01.hyp.32.5.875.
Ambrosius WT, Compton JA, Bowsher RR, Pratt JH. Relation of race, age, and sex hormone differences to serum leptin concentrations in children and adolescents. Horm Res. 1998;49(5):240-6. doi: 10.1159/000023178.
Zhou L, Ambrosius WT, Newman SA, Wagner MA, Pratt JH. Heart rate as a predictor of future blood pressure in schoolchildren. Am J Hypertens. 2000 Oct;13(10):1082-7. doi: 10.1016/s0895-7061(00)00295-8.
Jakubowski H, Ambrosius WT, Pratt JH. Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis. FEBS Lett. 2001 Feb 23;491(1-2):35-9. doi: 10.1016/s0014-5793(01)02143-3.
Ambrosius WT, Newman SA, Pratt JH. Rates of change in measures of body size vary by ethnicity and gender. Ethn Dis. 2001 Spring-Summer;11(2):303-10.
Pratt JH, Ambrosius WT, Agarwal R, Eckert GJ, Newman S. Racial difference in the activity of the amiloride-sensitive epithelial sodium channel. Hypertension. 2002 Dec;40(6):903-8. doi: 10.1161/01.hyp.0000039749.75068.f4.
Pratt JH, Eckert GJ, Newman S, Ambrosius WT. Blood pressure responses to small doses of amiloride and spironolactone in normotensive subjects. Hypertension. 2001 Nov;38(5):1124-9. doi: 10.1161/hy1101.095010.
Degawa-Yamauchi M, Dilts JR, Bovenkerk JE, Saha C, Pratt JH, Considine RV. Lower serum adiponectin levels in African-American boys. Obes Res. 2003 Nov;11(11):1384-90. doi: 10.1038/oby.2003.187.
Palacios C, Wigertz K, Martin BR, Jackman L, Pratt JH, Peacock M, McCabe G, Weaver CM. Sodium retention in black and white female adolescents in response to salt intake. J Clin Endocrinol Metab. 2004 Apr;89(4):1858-63. doi: 10.1210/jc.2003-031446.
Chun TY, Pratt JH. Non-genomic effects of aldosterone: new actions and questions. Trends Endocrinol Metab. 2004 Oct;15(8):353-4. doi: 10.1016/j.tem.2004.08.002.
Shankar RR, Ferrari P, Dick B, Ambrosius WT, Eckert GJ, Pratt JH. Activity of 11beta-hydroxysteroid dehydrogenase type 2 in normotensive blacks and whites. Ethn Dis. 2005 Summer;15(3):407-10.
Saha C, Eckert GJ, Pratt JH, Shankar RR. Onset of overweight during childhood and adolescence in relation to race and sex. J Clin Endocrinol Metab. 2005 May;90(5):2648-52. doi: 10.1210/jc.2004-2208. Epub 2005 Feb 22.
Shankar RR, Eckert GJ, Saha C, Tu W, Pratt JH. The change in blood pressure during pubertal growth. J Clin Endocrinol Metab. 2005 Jan;90(1):163-7. doi: 10.1210/jc.2004-0926. Epub 2004 Oct 27.
Study Completion
June 2003
Actual (reported)Last Updated
February 25, 2014
Record last verified: 2014-02
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