Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections

NCT00004996 | Completed

• 2 other identifiers: 00009900-I-0099
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering. This study may provide new information about the interactions between parasites and the immune system that could lead to better treatments for these infections. Normal volunteers and patients with acute helminth (a type of parasite) infections aged 18 years older may be eligible for this study. Following a medical history and physical exam, participants will undergo suction blistering to provide cells needed for study. A suction blister device is attached to the skin of the thigh. A heating element in the device heats the skin to speed blister formation. (This will feel only a slightly warm.) The device is removed after about two hours, when the blisters have formed. The blister tops are removed with sterile scissors. The blistered areas are then treated with special dressings to promote healing and the participant is discharged with further wound care instructions. A small amount of blood (around four tablespoons) may be drawn to compare chemicals in the blood with chemicals in the blister fluid. Participants will be contacted by telephone over the next 72 hours to check on healing. Further follow-up will occur by phone at 6 months and 1 year. Up to 60 blisters may be produced over a one-year period (in three separate sessions every six months) with no more than 20 raised per session....

Conditions

Healthy; Helminthiasis

Keywords

Antigen Presentation; Cytokines; Helminth; Healthy Volunteer; Cross-Over Study; Helminth Infection

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Between the ages of 18 and 65 years inclusive
• Access to a primary medical care provider outside of the NIH
• Able to give informed consent
• Willingness to have history and physical examination annually

You may not qualify if:

• History of malignancy or autoimmune disease such as rheumatoid arthritis, vasculitis, pyoderma gangrenosum
• Use of systemic corticosteroids within the past month
• Use of local corticosteroids at the proposed blistering site within the past month
• Evidence of current acute infection
• Personal or family history of keloid formation
• Use of any investigative drugs within the past month
• History of skin disease within the past one year (e.g. psoriasis, atopic dermatitis)
• History of diabetes

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Kiistala U. Suction blister device for separation of viable epidermis from dermis. J Invest Dermatol. 1968 Feb;50(2):129-37. doi: 10.1038/jid.1968.15. No abstract available.

  PMID: 4868034 BACKGROUND

• Blauvelt A, Katz SI, Udey MC. Human Langerhans cells express E-cadherin. J Invest Dermatol. 1995 Feb;104(2):293-6. doi: 10.1111/1523-1747.ep12612830.

  PMID: 7829887 BACKGROUND

• Dale DC, Wolff SM. Skin window studies of the acute inflammatory responses of neutropenic patients. Blood. 1971 Aug;38(2):138-42. No abstract available.

  PMID: 4933314 BACKGROUND

MeSH Terms

Conditions

Helminthiasis; Trematode Infections

Condition Hierarchy (Ancestors)

Parasitic Diseases; Infections

Study Officials

• Thomas B Nutman, M.D.

  National Institute of Allergy and Infectious Diseases (NIAID)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2000
• First Posted: March 23, 2000
• Study Start: March 20, 2000
• Study Completion: April 22, 2015
• Last Updated: December 12, 2019

Record last verified: 2015-04-22

Locations

US (1)