Study of New Magnetic Resonance Methods

NCT00001844 | Terminated

• 2 other identifiers: 99016399-CC-0163
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate new magnetic resonance imaging (MRI ) methods using a MRI machine more powerful than those in most hospitals. MRI is a diagnostic tool that uses a large magnet and radio waves to produce images of the human body. It can also provide information about brain chemistry and physiology. This study will use the new MRI hardware and methods to measure blood flow and metabolism in regions of the brain during simple tasks, such as listening to tones or watching flashing checkerboards. Healthy normal volunteers will undergo MRI scanning. For this procedure, the person lies on a stretcher that is moved into a MRI machine, which produces a strong magnetic field. A special lightweight coil is placed on the person's head to obtain better pictures. The scan time ranges from 20 minutes to 2 hours, with the average scan lasting between 45 and 90 minutes. During the MRI, the person may be asked to perform simple tasks, such as listening to tones or watching a screen, tapping fingers or moving a hand. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons. The images produced in this study will be compared with those produced using standard MRI. The results will be used to develop improved imaging methods for better patient care and research.

Conditions

Healthy

Keywords

MRI/MRS; Functional MRI; Metabolic Imaging; Brain; Healthy Volunteer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age 18 and older
• capable of providing own informed consent
• capable of filling out MRI screening form

You may not qualify if:

• contraindications for MRI including aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body (e.g. metal shavings); or insulin pump, or other metal in the body.
• pregnancy
• Subjects will be excluded if it is deemed that they have a condition that would preclude their participation for technical development (e.g. claustrophobia)
• Subjects will be excluded if they present unnecessary risk (e.g. Brain surgery of uncertain type, etc.).

Sponsors & Collaborators

• National Institutes of Health Clinical Center (CC): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72. doi: 10.1073/pnas.87.24.9868.

  PMID: 2124706 BACKGROUND

• Belliveau JW, Kennedy DN Jr, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR. Functional mapping of the human visual cortex by magnetic resonance imaging. Science. 1991 Nov 1;254(5032):716-9. doi: 10.1126/science.1948051.

  PMID: 1948051 BACKGROUND

• Turner R, Howseman A, Rees GE, Josephs O, Friston K. Functional magnetic resonance imaging of the human brain: data acquisition and analysis. Exp Brain Res. 1998 Nov;123(1-2):5-12. doi: 10.1007/s002210050538.

  PMID: 9835386 BACKGROUND

Study Officials

• Joseph A Frank, M.D.

  National Institutes of Health Clinical Center (CC)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: September 8, 1999
• Study Completion: September 7, 2012
• Last Updated: December 17, 2019

Record last verified: 2012-09-07

Locations

US (1)