Carotid Revascularization Endarterectomy Versus Stenting Trial
CREST
2 other identifiers
interventional
2,502
2 countries
115
Brief Summary
The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA (transient ischemic attack) or a mild stroke within the past 6 months (symptomatic) and in those patients who have not had any symptoms within the past 6 months (asymptomatic).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Dec 2000
Longer than P75 for not_applicable
115 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 25, 2000
CompletedFirst Posted
Study publicly available on registry
February 28, 2000
CompletedStudy Start
First participant enrolled
December 1, 2000
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2011
CompletedResults Posted
Study results publicly available
December 10, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2016
CompletedMay 17, 2017
April 1, 2017
10.2 years
February 25, 2000
September 26, 2013
April 13, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Any Periprocedural Stroke, Myocardial Infarction, or Death During a 30-day Peri-procedural Period, and Postprocedural Ipsilateral Stroke Thereafter, up to 4-years.
The primary aim of CREST is to assess if the efficacy of CAS differs from that of CEA in preventing stroke, myocardial infarction and death during a 30-day peri-procedural period, or ipsilateral stroke over the follow-up period in patients with symptomatic (\>=50%) or asymptomatic (\>=60%) extracranial carotid stenosis. Four-year follow-up, proportions reflecting the absolute efficacy of carotid-artery stenting (CAS) over that of carotid endarterectomy (CEA) were based on Kaplan-Meier survival estimates at the end of the 4 years.
30 days and 4 years
Secondary Outcomes (1)
Differential Efficacy of CAS and CEA in Male and Female Participants in the Primary Endpoint (Any Periprocedural Stroke, Myocardial Infarction, or Death or Postprocedural Ipsilateral Stroke).
4 years
Study Arms (2)
Carotid Artery Endarterectomy (CEA)
ACTIVE COMPARATORCarotid endarterectomy is surgery to remove plaque buildup that causes narrowing (stenosis) in the carotid artery.
Carotid Artery Stenting (CAS)
ACTIVE COMPARATORCarotid artery stenting (CAS) is a procedure used to open narrowed carotid arteries. During the procedure, a small, expandable wire tube called a stent is permanently inserted into the carotid artery.
Interventions
CEA involves a neck incision and physical removal of the plaque from the inside of the carotid artery.
CAS involves insertion of a catheter or tube into an artery in the groin and then threading the catheter through the arteries of the body to the location of the plaque within the carotid artery in the neck. A stent is then placed to cover the plaque and hold the artery open. Participants randomized to this arm of the trial were treated using the RX Acculink Carotid Stent with or without the RX Accunet Embolic Protection Device.
Eligibility Criteria
You may qualify if:
- Symptomatic patients with recent neurological events (TIA or non-disabling stroke) with an associated carotid stenosis greater than or equal to 50% by angiography or greater than or equal to 70% by ultrasound or greater than or equal to 70% by Computed Tomography Angiography (CTA) or Magnetic Resonance Angiography (MRA) are eligible for randomization.
- Asymptomatic patients with no recent (in the last 6 months) neurological events referable to the study with artery and carotid stenosis (patients with symptoms beyond 180 days are considered asymptomatic) greater than or equal to 60% by angiography or greater than or equal to 70% by ultrasound or greater than or equal to 80% by CTA or MRA are eligible for randomization.
You may not qualify if:
- Conditions that: (1) interfere with the evaluation of endpoints, (2) are known to interfere with the completion of CEA or CAS, or (3) affect the likelihood of survival for the study period (4 years). Chronic atrial fibrillation and/or anti-coagulation or episodic atrial fibrillation within the last 6 months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (115)
The Board of Trustees of the University of Alabama for the University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Dignity Health dba St. Joseph's Hospital & Medical Center
Phoenix, Arizona, 85013, United States
Mayo Clinic Arizona
Scottsdale, Arizona, 85259, United States
The Arizona Board of Regents for the University of Arizona
Tucson, Arizona, 85724, United States
Board of Trustees of the University of Arkansas
Little Rock, Arkansas, 72701, United States
USC University Hospital & LA County Hospital
Los Angeles, California, 90033, United States
The Regents of the University of California
Los Angeles, California, 90095, United States
Kaiser Permanente Medical Center
San Diego, California, 92120, United States
Northern California Institute for Research and Education
San Francisco, California, 94121, United States
Catholic Healthcare West
Stockton, California, 95204, United States
Christiana Care Health Services, Inc.
Newark, Delaware, 19718, United States
Morton Plant Hospital
Clearwater, Florida, 33756, United States
Mayo Clinic
Jacksonville, Florida, 32224, United States
Leesburg Medical Center
Leesburg, Florida, 34748, United States
Miami Cardiac & Vascular Institute of Baptist Hospital of Miami, Inc.
Miami, Florida, 33187, United States
Florida Hospital Neuroscience Institute, a division of Adventist Health System/Sunbelt, Inc.
Orlando, Florida, 32803, United States
Orlando Regional Medical Center
Orlando, Florida, 32828, United States
University of South Florida Board of Trustees
Tampa, Florida, 33606, United States
Piedmont Hospital/Fuqua Heart Center
Atlanta, Georgia, 30309, United States
Emory University
Atlanta, Georgia, 30322, United States
St. Joseph's of Atlanta
Atlanta, Georgia, 30342, United States
St. Joseph's Candler Health System
Savannah, Georgia, 31405, United States
Norwestern Memorial Hospital
Chicago, Illinois, 60611, United States
Alexian Brothers Specialty Group
Elk Grove Village, Illinois, 60007, United States
Loyola University of Chicago
Maywood, Illinois, 60153, United States
Peoria Radiology Research and Education
Peoria, Illinois, 61637, United States
Prarie Cardiology-St. John's Hospital
Springfield, Illinois, 62794, United States
Southern Illinois School of Medicine
Springfield, Illinois, 62794, United States
Central Dupage Hospital
Winfield, Illinois, 60190, United States
Lutheran Medical Group, LLC,
Fort Wayne, Indiana, 46804, United States
Parkview Hospital, Inc.
Fort Wayne, Indiana, 46805, United States
St. Vincent's Hospital
Indianapolis, Indiana, 46260, United States
Catholic Health Initiatives /Mercy Hospital Center
Des Moines, Iowa, 50314, United States
Baptist Healthcare System, Inc.
Lexington, Kentucky, 40504, United States
Vascular Surgery Associates
Baton Rouge, Louisiana, 70809, United States
Ochsner Foundation Hospital
New Orleans, Louisiana, 70121, United States
Anne Arundel Health System Research Institute
Annapolis, Maryland, 21401, United States
Johns Hopkins University
Baltimore, Maryland, 21287, United States
Adventist Healthcare, Inc.
Takoma Park, Maryland, 20912, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Steward St. Elizabeth's Medical Center of Boston, Inc.
Boston, Massachusetts, 02135, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Brigham and Womens Hospital, Inc.
Boston, Massachusetts, 02215, United States
Cape Cod Health Care, Inc.,
Hyannis, Massachusetts, 02601, United States
University of Michigan
Ann Arbor, Michigan, 48109, United States
Henry Ford Health System
Detroit, Michigan, 48202, United States
St. John Hospital and Medical Center
Detroit, Michigan, 48236, United States
Michigan Vascular Research Center
Flint, Michigan, 48507, United States
Spectrum Health Hospital
Grand Rapids, Michigan, 49503, United States
William Beaumont Hospital
Royal Oak, Michigan, 48075, United States
Providence St. John Hopital
Southfield, Michigan, 48075, United States
Michigan Heart & Vascular Institute/St. Joseph's Mercy Hospital
Ypsilanti, Michigan, 48197, United States
North Memorial Health Care
Robbinsdale, Minnesota, 55422, United States
Mayo Clinic Rochester/St. Mary's
Rochester, Minnesota, 55905, United States
Mississippi Baptist Medical Center, Inc.
Jackson, Mississippi, 39202, United States
Heartland Physician Services, LLC
Kansas City, Missouri, 64114, United States
Mercy Hospitals East Communities
St Louis, Missouri, 63141, United States
St. Patrick's Hospital International Heart Institute of MT
Missoula, Montana, 59802, United States
Dartmouth College and the constituent members of DARTMOUTH HITCHCOCK MEDICAL CENTER
Lebanon, New Hampshire, 03756, United States
St. Michael's Medical Center
Newark, New Jersey, 07013, United States
Center for Vascular Awareness, Inc.
Albany, New York, 12208, United States
Millard Fillmore SUNY Buffalo
Buffalo, New York, 14209, United States
NYU School of Medicine
New York, New York, 10016, United States
The Feinstein Institute for Medical Research
New York, New York, 10021, United States
Weill Medical College of Cornell University
New York, New York, 10021, United States
Columbia Presbyterian
New York, New York, 10032, United States
St. Francis Hospital
Port Washington, New York, 11050, United States
University of Rochester
Rochester, New York, 14642, United States
Richmond University Medical Center
Staten Island, New York, 10310, United States
Westchester Medical Center
Valhalla, New York, 10595, United States
UNC at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
The Charlotte-Mecklenburg Hospital Authority
Charlotte, North Carolina, 28203, United States
Duke University Medical Center
Durham, North Carolina, 27710, United States
Forsyth Radiological Associates
Winston-Salem, North Carolina, 27103, United States
Wake Forest University
Winston-Salem, North Carolina, 27157, United States
Christ Hospital
Cincinnati, Ohio, 45219, United States
University of Cincinnati
Cincinnati, Ohio, 45267, United States
The Cleveland Clinic Lerner College Of Medicine of CWRU
Cleveland, Ohio, 44195, United States
Midwest Ohio Health Research Institute
Columbus, Ohio, 43214, United States
The Toledo Hospital
Toledo, Ohio, 43606, United States
University of Toledo
Toledo, Ohio, 43614, United States
Oklahoma Foundation for Cardiovascular Research
Oklahoma City, Oklahoma, 73120, United States
Rogue Valley Medical Center
Medford, Oregon, 97504, United States
Oregon Health Science University
Portland, Oregon, 97201, United States
Lehigh Valley Hospital
Allentown, Pennsylvania, 18105, United States
Heritage Valley Medical Group
Beaver, Pennsylvania, 15009, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
Allegheny Singer Research Institute
Pittsburgh, Pennsylvania, 15212, United States
UPMC Presbyterian Shadyside
Pittsburgh, Pennsylvania, 15232, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
South Carolina Heart Center
Columbia, South Carolina, 29204, United States
Metro Knoxville HMA
Knoxville, Tennessee, 37920, United States
Baptist Memorial Hospital
Memphis, Tennessee, 38120, United States
The University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390, United States
Houston Methodist Hospital
Houston, Texas, 77030, United States
UT Houston Memorial
Houston, Texas, 77030, United States
Scott & White Memorial Hospital
Temple, Texas, 76508, United States
Intermountain Health Services
Salt Lake City, Utah, 84143, United States
University of Virginia
Charlottesville, Virginia, 22908, United States
Swedish Health Services
Seattle, Washington, 98122, United States
Providence Health & Services - Washington
Spokane, Washington, 99204, United States
Charleston Area Medical Center
Charleston, West Virginia, 25304, United States
Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
St. Luke's Medical Center
Milwaukee, Wisconsin, 53215, United States
Governors of the University of Calgary and the Calgary Health Region
Calgary, Alberta, T2N 2T9, Canada
The University of British Columbia and The Vancouver Coastal Health Authority
Vancouver, British Columbia, V5Z 3J5, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, R2H2A6, Canada
The Credit Valley Hospital and Trillium Health Centre
Mississauga, Ontario, L5B 4A2, Canada
Ottawa Hospital Research Institute
Ottawa, Ontario, K1H1A2, Canada
St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
University Health Network
Toronto, Ontario, M5T 2S8, Canada
Lawson Health Research Institute
Toronto, Ontario, N6A5A5, Canada
CHU de Québec
Québec, Quebec, G1J1Z4, Canada
Related Publications (43)
Hopkins LN, Roubin GS, Chakhtoura EY, Gray WA, Ferguson RD, Katzen BT, Rosenfield K, Goldstein J, Cutlip DE, Morrish W, Lal BK, Sheffet AJ, Tom M, Hughes S, Voeks J, Kathir K, Meschia JF, Hobson RW 2nd, Brott TG. The Carotid Revascularization Endarterectomy versus Stenting Trial: credentialing of interventionalists and final results of lead-in phase. J Stroke Cerebrovasc Dis. 2010 Mar;19(2):153-62. doi: 10.1016/j.jstrokecerebrovasdis.2010.01.001.
PMID: 20189092BACKGROUNDHoward VJ, Voeks JH, Lutsep HL, Mackey A, Milot G, Sam AD 2nd, Tom M, Hughes SE, Sheffet AJ, Longbottom M, Avery JB, Hobson RW 2nd, Brott TG. Does sex matter? Thirty-day stroke and death rates after carotid artery stenting in women versus men: results from the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) lead-in phase. Stroke. 2009 Apr;40(4):1140-7. doi: 10.1161/STROKEAHA.108.541847. Epub 2009 Feb 10.
PMID: 19211486BACKGROUNDSheffet AJ, Roubin G, Howard G, Howard V, Moore W, Meschia JF, Hobson RW 2nd, Brott TG. Design of the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST). Int J Stroke. 2010 Feb;5(1):40-6. doi: 10.1111/j.1747-4949.2009.00405.x.
PMID: 20088993BACKGROUNDLal BK, Brott TG. The Carotid Revascularization Endarterectomy vs. Stenting Trial completes randomization: lessons learned and anticipated results. J Vasc Surg. 2009 Nov;50(5):1224-31. doi: 10.1016/j.jvs.2009.09.003.
PMID: 19878793BACKGROUNDHobson RW 2nd, Brott TG, Roubin GS, Silver FL, Barnett HJ. Carotid artery stenting: meeting the recruitment challenge of a clinical trial. Stroke. 2005 Jun;36(6):1314-5. doi: 10.1161/01.STR.0000165919.26944.05. Epub 2005 Apr 28. No abstract available.
PMID: 15860747BACKGROUNDHobson RW 2nd, Howard VJ, Roubin GS, Brott TG, Ferguson RD, Popma JJ, Graham DL, Howard G; CREST Investigators. Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phase. J Vasc Surg. 2004 Dec;40(6):1106-11. doi: 10.1016/j.jvs.2004.10.022.
PMID: 15622363BACKGROUNDHobson RW 2nd, Howard VJ, Roubin GS, Ferguson RD, Brott TG, Howard G, Sheffet AJ, Roberts J, Hopkins LN, Moore WS; CREST. Credentialing of surgeons as interventionalists for carotid artery stenting: experience from the lead-in phase of CREST. J Vasc Surg. 2004 Nov;40(5):952-7. doi: 10.1016/j.jvs.2004.08.039.
PMID: 15557910BACKGROUNDHobson RW 2nd, Howard VJ, Brott TG, Howard G, Roubin GS, Ferguson RD; For the CREST Executive Committee. Organizing the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): National Institutes of Health, Health Care Financing Administration, and industry funding. Curr Control Trials Cardiovasc Med. 2001 Jul 13;2(4):160-164. doi: 10.1186/cvm-2-4-160.
PMID: 11806790BACKGROUNDHobson RW 2nd, Brott T, Ferguson R, Roubin G, Moore W, Kuntz R, Howard G, Ferguson J. CREST: carotid revascularization endarterectomy versus stent trial. Cardiovasc Surg. 1997 Oct;5(5):457-8. doi: 10.1016/s0967-2109(97)00048-3. No abstract available.
PMID: 9464598BACKGROUNDBrott TG, Hobson RW 2nd, Howard G, Roubin GS, Clark WM, Brooks W, Mackey A, Hill MD, Leimgruber PP, Sheffet AJ, Howard VJ, Moore WS, Voeks JH, Hopkins LN, Cutlip DE, Cohen DJ, Popma JJ, Ferguson RD, Cohen SN, Blackshear JL, Silver FL, Mohr JP, Lal BK, Meschia JF; CREST Investigators. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med. 2010 Jul 1;363(1):11-23. doi: 10.1056/NEJMoa0912321. Epub 2010 May 26.
PMID: 20505173RESULTMantese VA, Timaran CH, Chiu D, Begg RJ, Brott TG; CREST Investigators. The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): stenting versus carotid endarterectomy for carotid disease. Stroke. 2010 Oct;41(10 Suppl):S31-4. doi: 10.1161/STROKEAHA.110.595330.
PMID: 20876500RESULTSilver FL, Mackey A, Clark WM, Brooks W, Timaran CH, Chiu D, Goldstein LB, Meschia JF, Ferguson RD, Moore WS, Howard G, Brott TG; CREST Investigators. Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke. 2011 Mar;42(3):675-80. doi: 10.1161/STROKEAHA.110.610212. Epub 2011 Feb 9.
PMID: 21307169RESULTBlackshear JL, Cutlip DE, Roubin GS, Hill MD, Leimgruber PP, Begg RJ, Cohen DJ, Eidt JF, Narins CR, Prineas RJ, Glasser SP, Voeks JH, Brott TG; CREST Investigators. Myocardial infarction after carotid stenting and endarterectomy: results from the carotid revascularization endarterectomy versus stenting trial. Circulation. 2011 Jun 7;123(22):2571-8. doi: 10.1161/CIRCULATIONAHA.110.008250. Epub 2011 May 23.
PMID: 21606394RESULTVilain KR, Magnuson EA, Li H, Clark WM, Begg RJ, Sam AD 2nd, Sternbergh WC 3rd, Weaver FA, Gray WA, Voeks JH, Brott TG, Cohen DJ; CREST Investigators. Costs and cost-effectiveness of carotid stenting versus endarterectomy for patients at standard surgical risk: results from the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke. 2012 Sep;43(9):2408-16. doi: 10.1161/STROKEAHA.112.661355. Epub 2012 Jul 19.
PMID: 22821614RESULTLal BK, Beach KW, Roubin GS, Lutsep HL, Moore WS, Malas MB, Chiu D, Gonzales NR, Burke JL, Rinaldi M, Elmore JR, Weaver FA, Narins CR, Foster M, Hodgson KJ, Shepard AD, Meschia JF, Bergelin RO, Voeks JH, Howard G, Brott TG; CREST Investigators. Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST, a randomised controlled trial. Lancet Neurol. 2012 Sep;11(9):755-63. doi: 10.1016/S1474-4422(12)70159-X. Epub 2012 Aug 2.
PMID: 22857850RESULTHill MD, Brooks W, Mackey A, Clark WM, Meschia JF, Morrish WF, Mohr JP, Rhodes JD, Popma JJ, Lal BK, Longbottom ME, Voeks JH, Howard G, Brott TG; CREST Investigators. Stroke after carotid stenting and endarterectomy in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Circulation. 2012 Dec 18;126(25):3054-61. doi: 10.1161/CIRCULATIONAHA.112.120030. Epub 2012 Nov 16.
PMID: 23159552RESULTTimaran CH, Mantese VA, Malas M, Brown OW, Lal BK, Moore WS, Voeks JH, Brott TG; CREST Investigators. Differential outcomes of carotid stenting and endarterectomy performed exclusively by vascular surgeons in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). J Vasc Surg. 2013 Feb;57(2):303-8. doi: 10.1016/j.jvs.2012.09.014. Epub 2012 Dec 20.
PMID: 23265585RESULTMatsumura JS, Hanlon BM, Rosenfield K, Voeks JH, Howard G, Roubin GS, Brott TG. Treatment of carotid stenosis in asymptomatic, nonoctogenarian, standard risk patients with stenting versus endarterectomy trials. J Vasc Surg. 2022 Apr;75(4):1276-1283.e1. doi: 10.1016/j.jvs.2021.10.020. Epub 2021 Oct 22.
PMID: 34695552DERIVEDHoward VJ, Algra A, Howard G, Bonati LH, de Borst GJ, Bulbulia R, Calvet D, Eckstein HH, Fraedrich G, Greving JP, Halliday A, Hendrikse J, Jansen O, Brown MM, Mas JL, Ringleb PA, Brott TG; Carotid Stenosis Trialists' Collaboration. Absence of Consistent Sex Differences in Outcomes From Symptomatic Carotid Endarterectomy and Stenting Randomized Trials. Stroke. 2021 Jan;52(2):416-423. doi: 10.1161/STROKEAHA.120.030184. Epub 2021 Jan 25.
PMID: 33493046DERIVEDMuller MD, von Felten S, Algra A, Becquemin JP, Bulbulia R, Calvet D, Eckstein HH, Fraedrich G, Halliday A, Hendrikse J, Howard G, Gregson J, Jansen O, Brown MM, Mas JL, Brott TG, Ringleb PA, Bonati LH. Secular Trends in Procedural Stroke or Death Risks of Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis. Circ Cardiovasc Interv. 2019 Aug;12(8):e007870. doi: 10.1161/CIRCINTERVENTIONS.119.007870. Epub 2019 Aug 5.
PMID: 31378071DERIVEDMoore WS, Voeks JH, Roubin GS, Clark WM, Howard VJ, Jones MR, Brott TG; CREST Investigators. Duration of asymptomatic status and outcomes following carotid endarterectomy and carotid artery stenting in the Carotid Revascularization Endarterectomy vs Stenting Trial. J Vasc Surg. 2019 Jun;69(6):1797-1800. doi: 10.1016/j.jvs.2018.09.054. Epub 2019 Jan 8.
PMID: 30630649DERIVEDJones MR, Howard G, Roubin GS, Blackshear JL, Cohen DJ, Cutlip DE, Leimgruber PP, Rhodes D, Prineas RJ, Glasser SP, Lal BK, Voeks JH, Brott TG; CREST Investigators. Periprocedural Stroke and Myocardial Infarction as Risks for Long-Term Mortality in CREST. Circ Cardiovasc Qual Outcomes. 2018 Nov;11(11):e004663. doi: 10.1161/CIRCOUTCOMES.117.004663.
PMID: 30571337DERIVEDLal BK, Roubin GS, Jones M, Clark W, Mackey A, Hill MD, Voeks JH, Howard G, Hobson RW 2nd, Brott TG. Influence of multiple stents on periprocedural stroke after carotid artery stenting in the Carotid Revascularization Endarterectomy versus Stent Trial (CREST). J Vasc Surg. 2019 Mar;69(3):800-806. doi: 10.1016/j.jvs.2018.06.221. Epub 2018 Dec 4.
PMID: 30527940DERIVEDMuller MD, von Felten S, Algra A, Becquemin JP, Brown M, Bulbulia R, Calvet D, Eckstein HH, Fraedrich G, Halliday A, Hendrikse J, Gregson J, Howard G, Jansen O, Mas JL, Brott TG, Ringleb PA, Bonati LH; Carotid Stenosis Trialists' Collaboration. Immediate and Delayed Procedural Stroke or Death in Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis. Stroke. 2018 Nov;49(11):2715-2722. doi: 10.1161/STROKEAHA.118.020684.
PMID: 30355202DERIVEDSheffet AJ, Howard G, Sam A, Jamil Z, Weaver F, Chiu D, Voeks JH, Howard VJ, Hughes SE, Flaxman L, Longbottom ME, Brott TG; CREST Investigators. Challenge and Yield of Enrolling Racially and Ethnically Diverse Patient Populations in Low Event Rate Clinical Trials. Stroke. 2018 Jan;49(1):84-89. doi: 10.1161/STROKEAHA.117.018063. Epub 2017 Nov 30.
PMID: 29191852DERIVEDRantner B, Kollerits B, Roubin GS, Ringleb PA, Jansen O, Howard G, Hendrikse J, Halliday A, Gregson J, Eckstein HH, Calvet D, Bulbulia R, Bonati LH, Becquemin JP, Algra A, Brown MM, Mas JL, Brott TG, Fraedrich G; Carotid Stenosis Trialists' Collaboration. Early Endarterectomy Carries a Lower Procedural Risk Than Early Stenting in Patients With Symptomatic Stenosis of the Internal Carotid Artery: Results From 4 Randomized Controlled Trials. Stroke. 2017 Jun;48(6):1580-1587. doi: 10.1161/STROKEAHA.116.016233. Epub 2017 Apr 28.
PMID: 28455318DERIVEDBrott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA, Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks JH, Hobson RW 2nd; CREST Investigators. Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis. N Engl J Med. 2016 Mar 17;374(11):1021-31. doi: 10.1056/NEJMoa1505215. Epub 2016 Feb 18.
PMID: 26890472DERIVEDMoore WS, Popma JJ, Roubin GS, Voeks JH, Cutlip DE, Jones M, Howard G, Brott TG; CREST Investigators. Carotid angiographic characteristics in the CREST trial were major contributors to periprocedural stroke and death differences between carotid artery stenting and carotid endarterectomy. J Vasc Surg. 2016 Apr;63(4):851-7, 858.e1. doi: 10.1016/j.jvs.2015.08.119. Epub 2015 Nov 21.
PMID: 26610643DERIVEDMeschia JF, Hopkins LN, Altafullah I, Wechsler LR, Stotts G, Gonzales NR, Voeks JH, Howard G, Brott TG. Time From Symptoms to Carotid Endarterectomy or Stenting and Perioperative Risk. Stroke. 2015 Dec;46(12):3540-2. doi: 10.1161/STROKEAHA.115.011123. Epub 2015 Oct 22.
PMID: 26493675DERIVEDVoeks JH, Howard G, Roubin G, Farb R, Heck D, Logan W, Longbottom M, Sheffet A, Meschia JF, Brott TG. Mediators of the Age Effect in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke. 2015 Oct;46(10):2868-73. doi: 10.1161/STROKEAHA.115.009516. Epub 2015 Sep 8.
PMID: 26351359DERIVEDHoward G, Hopkins LN, Moore WS, Katzen BT, Chakhtoura E, Morrish WF, Ferguson RD, Hye RJ, Shawl FA, Harrigan MR, Voeks JH, Howard VJ, Lal BK, Meschia JF, Brott TG. Temporal Changes in Periprocedural Events in the Carotid Revascularization Endarterectomy Versus Stenting Trial. Stroke. 2015 Aug;46(8):2183-9. doi: 10.1161/STROKEAHA.115.008898. Epub 2015 Jul 14.
PMID: 26173731DERIVEDSheffet AJ, Voeks JH, Mackey A, Brooks W, Clark WM, Hill MD, Howard VJ, Hughes SE, Tom M, Longbottom ME, Brott TG; CREST Investigators. Characteristics of participants consenting versus declining follow-up for up to 10 years in a randomized clinical trial. Clin Trials. 2015 Dec;12(6):657-63. doi: 10.1177/1740774515590807. Epub 2015 Jun 29.
PMID: 26122922DERIVEDMalas M, Glebova NO, Hughes SE, Voeks JH, Qazi U, Moore WS, Lal BK, Howard G, Llinas R, Brott TG. Effect of patching on reducing restenosis in the carotid revascularization endarterectomy versus stenting trial. Stroke. 2015 Mar;46(3):757-61. doi: 10.1161/STROKEAHA.114.007634. Epub 2015 Jan 22.
PMID: 25613307DERIVEDMeschia JF, Voeks JH, Leimgruber PP, Mantese VA, Timaran CH, Chiu D, Demaerschalk BM, Howard VJ, Hughes SE, Longbottom M, Howard AG, Brott TG. Management of vascular risk factors in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). J Am Heart Assoc. 2014 Nov 26;3(6):e001180. doi: 10.1161/JAHA.114.001180.
PMID: 25428209DERIVEDGonzales NR, Demaerschalk BM, Voeks JH, Tom M, Howard G, Sheffet AJ, Garcia L, Clair DG, Barr J, Orlow S, Brott TG; CREST Investigators. Complication rates and center enrollment volume in the carotid revascularization endarterectomy versus stenting trial. Stroke. 2014 Nov;45(11):3320-4. doi: 10.1161/STROKEAHA.114.006228. Epub 2014 Sep 25.
PMID: 25256180DERIVEDHoward G, Voeks JH, Meschia JF, Howard VJ, Brott TG. Picking the good apples: statistics versus good judgment in choosing stent operators for a multicenter clinical trial. Stroke. 2014 Nov;45(11):3325-9. doi: 10.1161/STROKEAHA.114.006807. Epub 2014 Sep 11.
PMID: 25213339DERIVEDSheffet AJ, Flaxman L, Tom M, Hughes SE, Longbottom ME, Howard VJ, Marler JR, Brott TG; CREST Investigators. Financial management of a large multisite randomized clinical trial. Int J Stroke. 2014 Aug;9(6):811-3. doi: 10.1111/ijs.12259. Epub 2014 Mar 24.
PMID: 24661748DERIVEDZierler RE, Beach KW, Bergelin RO, Lal BK, Moore WS, Roubin GS, Voeks JH, Brott TG; CREST Investigators. Agreement between site-reported and ultrasound core laboratory results for duplex ultrasound velocity measurements in the Carotid Revascularization Endarterectomy versus Stenting Trial. J Vasc Surg. 2014 Jan;59(1):2-7. doi: 10.1016/j.jvs.2013.06.071. Epub 2013 Sep 19.
PMID: 24055515DERIVEDHabersberger J, Brott TG, Roubin GS. Carotid artery stenting: a clinical update. Curr Opin Cardiol. 2012 Nov;27(6):565-71. doi: 10.1097/HCO.0b013e3283587506.
PMID: 22941123DERIVEDVoeks JH, Howard G, Roubin GS, Malas MB, Cohen DJ, Sternbergh WC 3rd, Aronow HD, Eskandari MK, Sheffet AJ, Lal BK, Meschia JF, Brott TG; CREST Investigators. Age and outcomes after carotid stenting and endarterectomy: the carotid revascularization endarterectomy versus stenting trial. Stroke. 2011 Dec;42(12):3484-90. doi: 10.1161/STROKEAHA.111.624155. Epub 2011 Oct 6.
PMID: 21980205DERIVEDCohen DJ, Stolker JM, Wang K, Magnuson EA, Clark WM, Demaerschalk BM, Sam AD Jr, Elmore JR, Weaver FA, Aronow HD, Goldstein LB, Roubin GS, Howard G, Brott TG; CREST Investigators. Health-related quality of life after carotid stenting versus carotid endarterectomy: results from CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial). J Am Coll Cardiol. 2011 Oct 4;58(15):1557-65. doi: 10.1016/j.jacc.2011.05.054.
PMID: 21958882DERIVEDChimowitz MI, Lynn MJ, Derdeyn CP, Turan TN, Fiorella D, Lane BF, Janis LS, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Torbey MT, Zaidat OO, Rumboldt Z, Cloft HJ; SAMMPRIS Trial Investigators. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011 Sep 15;365(11):993-1003. doi: 10.1056/NEJMoa1105335. Epub 2011 Sep 7.
PMID: 21899409DERIVEDHoward VJ, Lutsep HL, Mackey A, Demaerschalk BM, Sam AD 2nd, Gonzales NR, Sheffet AJ, Voeks JH, Meschia JF, Brott TG; CREST investigators. Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Lancet Neurol. 2011 Jun;10(6):530-7. doi: 10.1016/S1474-4422(11)70080-1. Epub 2011 May 5.
PMID: 21550314DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Thomas G. Brott, MD - Principal Investigator
- Organization
- Mayo Clinic
Study Officials
- PRINCIPAL INVESTIGATOR
Thomas G. Brott, M.D.
Mayo Clinic and Rutgers University
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 25, 2000
First Posted
February 28, 2000
Study Start
December 1, 2000
Primary Completion
February 1, 2011
Study Completion
December 1, 2016
Last Updated
May 17, 2017
Results First Posted
December 10, 2013
Record last verified: 2017-04
Data Sharing
- IPD Sharing
- Will not share