Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers With 3.0 Tesla MRI and Magnetoencephalography
Sponsor study identifier
Secondary identifiers
observational
3,273
1 country
1
Study Start
February 17, 2000
Actual (reported)Primary Completion
Not reported
Date not reportedStudy Completion
Not reported
Date not reportedThe purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. Schizophrenia is a brain disorder that results from subtle changes and abnormalities in neurons. These deficits likely occur in localized regions of the brain and may result in widespread, devastating consequences. The neuronal abnormalities are inherited through a complex combination of genetic and environmental factors. Brain imaging technologies can be used to better characterize brain changes in individuals with schizophrenia. This study will use magnetic resonance imaging (MRI) scans to identify predictable, quantifiable abnormalities in neurophysiology, neurochemistry and neuroanatomy that characterize schizophrenia and other neurological and neuropsychiatric disorders.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 15, 2000
Actual (reported)February 16, 2000
Actual (reported)February 17, 2000
Actual (reported)regional MRSI measures
GABA and glutamate measurements in schizophrenia and healthy controls.
spectroscopy
magnetic field potentials
Group differences in MEG signal for patients with schizophrenia and healthy subjects.
MEG
fMRI BOLD responses
Group differences between patients with schizophrenia and healthy subjects, also genotyping used to characterize subjects as well.
MRI study completion
DTI anisotropy measures
Compare fractional anisotropy and other measures of white matter connectivity for schizophrenic patients and controls.
DTI
neuropsychological task performance data
NPT
Healthy subjects from the community
Patients with schizophrenia and psychosis
Individuals with copy number variation in the Williams Syndrome Region
Patients with schizophrenia and healthy subjects from the community.
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Ianni AM, Eisenberg DP, Boorman ED, Constantino SM, Hegarty CE, Gregory MD, Masdeu JC, Kohn PD, Behrens TE, Berman KF. PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging. Nat Commun. 2023 Sep 30;14(1):6122. doi: 10.1038/s41467-023-41897-0.
Kippenhan JS, Gregory MD, Nash T, Kohn P, Mervis CB, Eisenberg DP, Garvey MH, Roe K, Morris CA, Kolachana B, Pani AM, Sorcher L, Berman KF. Dorsal visual stream and LIMK1: hemideletion, haplotype, and enduring effects in children with Williams syndrome. J Neurodev Disord. 2023 Aug 26;15(1):29. doi: 10.1186/s11689-023-09493-x.
Karen F Berman, M.D.
National Institute of Mental Health (NIMH)
3,273 participants (actual enrollment reported by the registry).
First Submitted
February 15, 2000
First Posted
February 16, 2000
Study Start
February 17, 2000
Actual (reported)Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings
brain volumetric measures
VBM and cortical parcellation are used in schizophrenia and healthy controls.
VBM
Contact the study team to confirm eligibility.
Rubinstein DY, Eisenberg DP, Carver FW, Holroyd T, Apud JA, Coppola R, Berman KF. Spatiotemporal Alterations in Working Memory-Related Beta Band Neuromagnetic Activity of Patients With Schizophrenia On and Off Antipsychotic Medication: Investigation With MEG. Schizophr Bull. 2023 May 3;49(3):669-678. doi: 10.1093/schbul/sbac178.
Marenco S, Meyer C, van der Veen JW, Zhang Y, Kelly R, Shen J, Weinberger DR, Dickinson D, Berman KF. Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition. Neuropsychopharmacology. 2018 Oct;43(11):2285-2291. doi: 10.1038/s41386-018-0134-5. Epub 2018 Jul 3.
Jabbi M, Cropp B, Nash T, Kohn P, Kippenhan JS, Masdeu JC, Mattay R, Kolachana B, Berman KF. BDNF Val66Met polymorphism tunes frontolimbic circuitry during affective contextual learning. Neuroimage. 2017 Nov 15;162:373-383. doi: 10.1016/j.neuroimage.2017.08.080. Epub 2017 Sep 1.
Wei SM, Baller EB, Kohn PD, Kippenhan JS, Kolachana B, Soldin SJ, Rubinow DR, Schmidt PJ, Berman KF. Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study. Mol Psychiatry. 2018 Apr;23(4):1066-1075. doi: 10.1038/mp.2017.72. Epub 2017 Apr 18.
Jabbi M, Chen Q, Turner N, Kohn P, White M, Kippenhan JS, Dickinson D, Kolachana B, Mattay V, Weinberger DR, Berman KF. Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli. Transl Psychiatry. 2015 Aug 18;5(8):e622. doi: 10.1038/tp.2015.98.
Jabbi M, Kohn PD, Nash T, Ianni A, Coutlee C, Holroyd T, Carver FW, Chen Q, Cropp B, Kippenhan JS, Robinson SE, Coppola R, Berman KF. Convergent BOLD and Beta-Band Activity in Superior Temporal Sulcus and Frontolimbic Circuitry Underpins Human Emotion Cognition. Cereb Cortex. 2015 Jul;25(7):1878-88. doi: 10.1093/cercor/bht427. Epub 2014 Jan 23.
Last Updated
October 13, 2026
Record last verified: 2026-07-22
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