Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions

NCT00004550 | Completed

• 2 other identifiers: 00006700-M-0067
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to better understand the long-term progress of people with obsessive-compulsive disorder (OCD) and related conditions such as anorexia nervosa, Tourette syndrome, and trichotillomania. This study involves the screening and follow-up of individuals with OCD and OCD-related disorders. Participants will be screened with a medical and psychiatric evaluation, questionnaires, and neurological testing. Participants will then have study visits every 4 to 12 weeks to undergo symptom and daily functioning evaluations, personality tests, blood and urine tests, memory tests, brain scans, and other clinical exams. Participants will be assessed with interviews and paper-and-pencil or computer-assisted tests. Participants may have the opportunity to participate in drug studies and to join a monthly OCD support group. At the end of the study, participants will be referred to community or private treatment centers.

Conditions

Anorexia Nervosa; Obsessive Compulsive Disorder; Tourette Syndrome; Trichotillomania

Keywords

Screening; Longitudinal; Transition; Treatment; Comorbidity; Obsessive Compulsive Disorder; Evaluation; Follow-Up; OC Spectrum Disorders; OCD

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals must fulfill DSM IV criteria for OCD or OCD-related disorders as determined by a complete psychiatric diagnostic interview (SCID-I, using DSM IV-TR).
• Individuals must be capable of decision making, and able to comprehend the purpose of the study and to provide informed consent.
• Individuals can be included if they have certain medical conditions that have been described to have a higher incidence of OCD/depression and anxiety disorders: e.g., individuals with underlying neurological or neuropsychiatric conditions (e.g., tic disorders or dystonias, including torticollis and blepharospasm), connective tissue disorders, but must show no other serious or acute medical illnesses as determined by a physical exam and standard laboratory examinations.
• Individuals must be at least 18 years old.

You may not qualify if:

• Alcohol or substance use or dependence of sufficient magnitude to require independent, concurrent treatment intervention (e.g., antabuse or opiate treatment, but not including self-help groups).
• Current history of aggressive behavior or current suicidal ideation with plan and intent.
• Current active psychosis.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Wiggs CL, Martin A, Altemus M, Murphy DL. Hypervigilance in patients with obsessive-compulsive disorder. Anxiety. 1996;2(3):123-9. doi: 10.1002/(SICI)1522-7154(1996)2:33.0.CO;2-Q.

  PMID: 9160613 BACKGROUND

MeSH Terms

Conditions

Anorexia Nervosa; Obsessive-Compulsive Disorder; Tourette Syndrome; Trichotillomania

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders; Anxiety Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Disruptive, Impulse Control, and Conduct Disorders

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 3, 2000
• First Posted: February 4, 2000
• Study Start: January 28, 2000
• Study Completion: April 21, 2008
• Last Updated: July 2, 2017

Record last verified: 2008-04-21

Locations

US (1)