Genetics of Obsessive-Compulsive Disorder

NCT00001548 | Completed

• 2 other identifiers: 96012496-M-0124
• Study Type: observational
• Target: 1,067
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD. OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.

Conditions

Obsessive Compulsive Disorder

Keywords

Genetic; Psychiatric Disorder; Affected Sib Pairs; Obsessions; Compulsions; Family Study; OCD Spectrum Disorders; Trichotillomania; Tourette's Syndrome

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.
• Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.
• Persons with primary behavioral difficulties who do not fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Wendland JR, Moya PR, Timpano KR, Anavitarte AP, Kruse MR, Wheaton MG, Ren-Patterson RF, Murphy DL. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry. 2009 Apr;66(4):408-16. doi: 10.1001/archgenpsychiatry.2009.6.

  PMID: 19349310 BACKGROUND

• Zuchner S, Wendland JR, Ashley-Koch AE, Collins AL, Tran-Viet KN, Quinn K, Timpano KC, Cuccaro ML, Pericak-Vance MA, Steffens DC, Krishnan KR, Feng G, Murphy DL. Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Mol Psychiatry. 2009 Jan;14(1):6-9. doi: 10.1038/mp.2008.83. No abstract available.

  PMID: 19096451 BACKGROUND

• Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet. 2008 Mar 1;17(5):717-23. doi: 10.1093/hmg/ddm343. Epub 2007 Nov 30.

  PMID: 18055562 BACKGROUND

MeSH Terms

Conditions

Obsessive-Compulsive Disorder; Mental Disorders; Obsessive Behavior; Compulsive Behavior; Trichotillomania; Tourette Syndrome

Condition Hierarchy (Ancestors)

Anxiety Disorders; Behavioral Symptoms; Behavior; Impulsive Behavior; Disruptive, Impulse Control, and Conduct Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders

Study Officials

• Francis J McMahon, M.D.

  National Institute of Mental Health (NIMH)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: August 22, 1996
• Study Completion: September 29, 2015
• Last Updated: October 6, 2017

Record last verified: 2015-09-29

Locations

US (1)