Combination Chemotherapy in Treating Children With Neuroblastoma
Treatment for Infants and Children With Intermediate Risk Neuroblastoma: A Phase III Intergroup CCG/POG Study
5 other identifiers
interventional
573
7 countries
235
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Combination chemotherapy plus surgery may be an effective treatment for neuroblastoma. PURPOSE: This phase III trial is studying how well combination chemotherapy followed by surgery works in treating young patients with neuroblastoma.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 1988
Longer than P75 for phase_3
235 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 1988
CompletedFirst Submitted
Initial submission to the registry
November 1, 1999
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2011
CompletedAugust 1, 2014
July 1, 2014
18.5 years
November 1, 1999
July 31, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Event Free Survival
Study Arms (1)
Treatment
EXPERIMENTALSee detailed description.
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- Children's Oncology Grouplead
- National Cancer Institute (NCI)collaborator
Study Sites (235)
Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
University of South Alabama Cancer Research Institute
Mobile, Alabama, 36604, United States
Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, 85724, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Southern California Permanente Medical Group
Downey, California, 90242, United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-3000, United States
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658, United States
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Loma Linda, California, 92354, United States
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
Long Beach, California, 90801-1428, United States
Children's Hospital Los Angeles
Los Angeles, California, 90027-0700, United States
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
Jonsson Comprehensive Cancer Center at UCLA
Los Angeles, California, 90095-1781, United States
Children's Hospital Central California
Madera, California, 93638-8762, United States
Children's Hospital and Research Center - Oakland
Oakland, California, 94609-1809, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
Orange, California, 92868, United States
Children's Hospital of Orange County
Orange, California, 92868, United States
Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
Sutter Cancer Center
Sacramento, California, 95816, United States
University of California Davis Cancer Center
Sacramento, California, 95817, United States
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, 95825, United States
Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego
San Diego, California, 92120, United States
Children's Hospital and Health Center - San Diego
San Diego, California, 92123-4282, United States
UCSF Comprehensive Cancer Center
San Francisco, California, 94143, United States
Santa Barbara Cottage Children's Hospital
Santa Barbara, California, 93102, United States
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
Santa Clara, California, 95051, United States
General Robert Huyser Cancer Center at David Grant Medical Center
Travis Air Force Base, California, 94535, United States
Children's Hospital Cancer Center
Denver, Colorado, 80218, United States
Presbyterian - St. Luke's Medical Center
Denver, Colorado, 80218, United States
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
Farmington, Connecticut, 06360-7106, United States
Yale Comprehensive Cancer Center at Yale University School of Medicine
New Haven, Connecticut, 06520-8064, United States
Alfred I. duPont Hospital for Children
Wilmington, Delaware, 19899, United States
Lombardi Cancer Center at Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
Children's National Medical Center
Washington D.C., District of Columbia, 20010-2970, United States
Broward General Medical Center Cancer Center
Fort Lauderdale, Florida, 33316, United States
Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908, United States
University of Florida Shands Cancer Center
Gainesville, Florida, 32610-0296, United States
Joe DiMaggio Children's Hospital at Memorial
Hollywood, Florida, 33021, United States
Nemours Children's Clinic
Jacksonville, Florida, 32207, United States
Jackson Memorial Hospital
Miami, Florida, 33136, United States
Miami Children's Hospital
Miami, Florida, 33155, United States
Baptist-South Miami Regional Cancer Program
Miami, Florida, 33176-2197, United States
Florida Hospital Cancer Institute
Orlando, Florida, 32804, United States
Nemours Children's Clinic - Orlando
Orlando, Florida, 32806, United States
Sacred Heart Children's Hospital
Pensacola, Florida, 32504, United States
All Children's Hospital
St. Petersburg, Florida, 33701, United States
St. Joseph's Children's Hospital of Tampa
Tampa, Florida, 33677-4227, United States
Kaplan Cancer Center at St. Mary's Medical Center
West Palm Beach, Florida, 33407, United States
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus
Atlanta, Georgia, 30342, United States
MBCCOP-Medical College of Georgia Cancer Center
Augusta, Georgia, 30912-4000, United States
Medical Center of Central Georgia
Macon, Georgia, 31201, United States
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, 31405, United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813, United States
MBCCOP - Hawaii
Honolulu, Hawaii, 96813, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000, United States
St. Luke's Mountain States Tumor Institute - Boise
Boise, Idaho, 83712, United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60601, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
University of Illinois at Chicago Cancer Center
Chicago, Illinois, 60612, United States
Children's Memorial Hospital - Chicago
Chicago, Illinois, 60614, United States
Advocate Hope Children's Hospital
Oak Lawn, Illinois, 60453, United States
Lutheran General Cancer Care Center
Park Ridge, Illinois, 60068-1174, United States
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637, United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62794-9658, United States
Riley's Children Cancer Center at Riley Hospital for Children
Indianapolis, Indiana, 46202-5225, United States
St. Vincent Indianapolis Hospital
Indianapolis, Indiana, 46260, United States
Blank Children's Hospital
Des Moines, Iowa, 50308, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, 52242-1009, United States
Wesley Medical Center
Wichita, Kansas, 67214, United States
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536-0284, United States
Kosair Children's Hospital
Louisville, Kentucky, 40202-3830, United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Tulane Cancer Center at Tulane University Hospital and Clinic
New Orleans, Louisiana, 70112, United States
Children's Hospital of New Orleans
New Orleans, Louisiana, 70118, United States
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
Pediatric Specialty Clinic at Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Maine Children's Cancer Program
Scarborough, Maine, 04074-9308, United States
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, 21201-1595, United States
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
Baltimore, Maryland, 21215, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231-7223, United States
Walter Reed Army Medical Center
Silver Spring, Maryland, 20910, United States
Floating Hospital for Children
Boston, Massachusetts, 02111, United States
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
Baystate Regional Cancer Program at D'Amour Center for Cancer Care
Springfield, Massachusetts, 01107, United States
UMASS Memorial Cancer Center - University Campus
Worcester, Massachusetts, 01655, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0914, United States
Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
Detroit, Michigan, 48236, United States
Hurley Medical Center
Flint, Michigan, 48503, United States
DeVos Children's Hospital
Grand Rapids, Michigan, 49503, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007-5364, United States
Breslin Cancer Center at Ingham Regional Medical Center
Lansing, Michigan, 48910, United States
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769, United States
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, 48073-6769, United States
St. Mary's - Duluth Clinic Cancer Center
Duluth, Minnesota, 55805, United States
Children's Hospitals and Clinics - Minneapolis/St. Paul
Minneapolis, Minnesota, 55404, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505, United States
University of Missouri - Columbia
Columbia, Missouri, 65203, United States
Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
Cardinal Glennon Children's Hospital
St Louis, Missouri, 63104, United States
St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
Children's Hospital of Omaha
Omaha, Nebraska, 68114, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, 68198-2168, United States
Nevada Cancer Research Foundation
Las Vegas, Nevada, 89109, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08903, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112-2094, United States
St. Joseph's Hospital and Medical Center
Paterson, New Jersey, 07503, United States
Valerie Fund Children's Center at Atlantic Health
Summit, New Jersey, 07901, United States
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, 87131, United States
Children's Hospital at Albany Medical Center
Albany, New York, 12208, United States
Brooklyn Hospital Center
Brooklyn, New York, 11201-5493, United States
SUNY Downstate Medical Center
Brooklyn, New York, 11203, United States
Brookdale University Hospital and Medical Center
Brooklyn, New York, 11212, United States
Maimonides Medical Center
Brooklyn, New York, 11219, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001, United States
Schneider Children's Hospital
New Hyde Park, New York, 11040, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021, United States
New York Weill Cornell Cancer Center at Cornell University
New York, New York, 10021, United States
Mount Sinai Medical Center
New York, New York, 10029, United States
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, 10032, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
Long Island Cancer Center at Stony Brook University Hospital
Stony Brook, New York, 11794-8174, United States
SUNY Upstate Medical University Hospital
Syracuse, New York, 13210, United States
Albert Einstein Cancer Center at Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
New York Medical College
Valhalla, New York, 10595, United States
Mission Hospitals - Memorial Campus
Asheville, North Carolina, 28801, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599, United States
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, 28232-2861, United States
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, 28233, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710, United States
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
Greenville, North Carolina, 27858-4354, United States
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1081, United States
Dakota Cancer Institute at Innovis Health - Dakota Clinic
Fargo, North Dakota, 58103-4940, United States
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308-1062, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3039, United States
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
Cleveland, Ohio, 44106-5065, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
Columbus Children's Hospital
Columbus, Ohio, 43205-2696, United States
Children's Medical Center - Dayton
Dayton, Ohio, 45404, United States
Toledo Children's Hospital
Toledo, Ohio, 43601, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Tod Children's Hospital - Forum Health
Youngstown, Ohio, 44501, United States
Children's Hospital at Oklahoma University Medical Center
Oklahoma City, Oklahoma, 73104, United States
CCOP - Oklahoma
Tulsa, Oklahoma, 74136, United States
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, 74136, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
Legacy Emanuel Hospital and Health Center & Children's Hospital
Portland, Oregon, 97227, United States
Doernbecher Children's Hospital at Oregon Health & Science University
Portland, Oregon, 97239-3098, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822-1320, United States
Penn State Children's Hospital
Hershey, Pennsylvania, 17033, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
St. Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134-1095, United States
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425-0721, United States
Palmetto Health South Carolina Cancer Center
Columbia, South Carolina, 29203, United States
Children's Hospital of Greenville Hospital System
Greenville, South Carolina, 29605, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105-1080, United States
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, 57117-5039, United States
East Tennessee State University Cancer Center at Johnson City Medical Center
Johnson City, Tennessee, 37614-0622, United States
East Tennessee Children's Hospital
Knoxville, Tennessee, 37901, United States
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
Vanderbilt Children's Hospital
Nashville, Tennessee, 37232-6310, United States
Texas Tech University Health Sciences Center School of Medicine
Amarillo, Texas, 79106, United States
Children's Hospital of Austin
Austin, Texas, 78701, United States
Medical City Dallas Hospital
Dallas, Texas, 75230, United States
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390-9063, United States
Cook Children's Medical Center - Fort Worth
Fort Worth, Texas, 76104, United States
University of Texas Medical Branch
Galveston, Texas, 77555-0209, United States
M.D. Anderson Cancer Center at University of Texas
Houston, Texas, 77030-4009, United States
Cancer Center at Baylor College of Medicine
Houston, Texas, 77030, United States
Wilford Hall Medical Center
Lackland Air Force Base, Texas, 78236-5300, United States
Covenant Children's Hospital
Lubbock, Texas, 79410, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78207, United States
MBCCOP - South Texas Pediatrics
San Antonio, Texas, 78229-3900, United States
Methodist Cancer Center at Methodist Specialty and Transplant Hospital
San Antonio, Texas, 78229-3902, United States
CCOP - Scott and White Hospital
Temple, Texas, 76508, United States
Center for Cancer Prevention and Care at Scott and White Clinic
Temple, Texas, 76508, United States
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112, United States
Vermont Cancer Center at University of Vermont
Burlington, Vermont, 05401-3498, United States
University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
INOVA Fairfax Hospital
Falls Church, Virginia, 22042-3300, United States
Children's Hospital of the King's Daughters
Norfolk, Virginia, 23507, United States
Naval Medical Center - Portsmouth
Portsmouth, Virginia, 23708-5100, United States
Massey Cancer Center at Virginia Commonwealth University
Richmond, Virginia, 23298-0121, United States
Carilion Medical Center for Children at Roanoke Community Hospital
Roanoke, Virginia, 24029, United States
Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024, United States
Group Health Central Hospital
Seattle, Washington, 98112, United States
Deaconess Medical Center
Spokane, Washington, 99210-0248, United States
Mary Bridge Children's Hospital and Health Center - Tacoma
Tacoma, Washington, 98415-0299, United States
Madigan Army Medical Center
Tacoma, Washington, 98431-0001, United States
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
Charleston, West Virginia, 25302, United States
Cabell Huntington Hospital
Huntington, West Virginia, 25701, United States
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, 26506-9300, United States
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301, United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54301, United States
St. Vincent Hospital
Green Bay, Wisconsin, 54307-9070, United States
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164, United States
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, 54449-5772, United States
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, 54449, United States
Midwest Children's Cancer Center
Milwaukee, Wisconsin, 53226, United States
Sydney Children's Hospital
Randwick, New South Wales, 2031, Australia
Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
Royal Children's Hospital
Brisbane, Queensland, 4029, Australia
Women's and Children's Hospital
North Adelaide, South Australia, 5006, Australia
Royal Children's Hospital
Parkville, Victoria, 3052, Australia
Princess Margaret Hospital for Children
Perth, Western Australia, 6001, Australia
Alberta Children's Hospital
Calgary, Alberta, T2T 5C7, Canada
Cross Cancer Institute at University of Alberta
Edmonton, Alberta, T6G 1Z2, Canada
Children's & Women's Hospital of British Columbia
Vancouver, British Columbia, V6H 3V4, Canada
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
Janeway Children's Health and Rehabilitation Centre
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
IWK Health Centre
Halifax, Nova Scotia, NS B3J 3G9, Canada
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, L8S 4J9, Canada
Children's Hospital of Western Ontario
London, Ontario, N6C 2V5, Canada
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
Montreal Children's Hospital at McGill University Health Center
Montreal, Quebec, H3H 1P3, Canada
Hopital Sainte Justine
Montreal, Quebec, H3T 1C5, Canada
Centre de Recherche du Centre Hospitalier de l'Universite Laval
Sainte-Foy, Quebec, GIV 4G2, Canada
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, S4T 7T1, Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
University Medical Center Groningen
Groningen, 9700 RB, Netherlands
Starship Children's Health
Auckland, New Zealand
Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus
San Juan, 00936-5067, Puerto Rico
San Jorge Children's Hospital
Santurce, 00912, Puerto Rico
Swiss Pediatric Oncology Group Bern
Bern, CH 3010, Switzerland
Swiss Pediatric Oncology Group Geneva
Geneva, CH 1211, Switzerland
Swiss Pediatric Oncology Group Lausanne
Lausanne, CH 1011, Switzerland
Related Publications (6)
Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Int J Mol Imaging. 2012;2012:250834. doi: 10.1155/2012/250834. Epub 2012 Sep 25.
PMID: 23050139BACKGROUNDMarachelian A, Shimada H, Sano H, Jackson H, Stein J, Sposto R, Matthay KK, Baker D, Villablanca JG. The significance of serial histopathology in a residual mass for outcome of intermediate risk stage 3 neuroblastoma. Pediatr Blood Cancer. 2012 May;58(5):675-81. doi: 10.1002/pbc.23250.
PMID: 22493777BACKGROUNDMeany HJ, Attiyeh EF, Naranjo A, et al.: Outcome analysis of non-high-risk neuroblastoma patients enrolled on Children's Oncology Group trials P9641 and A3961. [Abstract] J Clin Oncol 30 (Suppl 15): A-9533, 2012.
BACKGROUNDAttiyeh EF, Mosse YP, Diskin S, et al.: Identification of genomic DNA signatures predicting relapse in low- and intermediate- risk neuroblastoma using a case control design and high-density SNP genotyping: a Children's Oncology Group (COG) study. [Abstract] J Clin Oncol 25 (Suppl 18): A-9500, 526s, 2007.
BACKGROUNDBaker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, Stram D, Castleberry RP, Shimada H, Sandler A, Shamberger RC, Look AT, Reynolds CP, Seeger RC, Matthay KK; Children's Oncology Group. Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010 Sep 30;363(14):1313-23. doi: 10.1056/NEJMoa1001527.
PMID: 20879880RESULTBaker DL, Schmidt M, Cohn S, et al.: A phase III trial of biologically-based therapy reduction for intermediate risk neuroblastoma. [Abstract] J Clin Oncol 25 (Suppl 18): A-9504, 2007.
RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
David L. Baker, MD, MBBS, FRACP, FRCPA
Princess Margaret Hospital for Children
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 1, 1999
First Posted
January 27, 2003
Study Start
March 1, 1988
Primary Completion
September 1, 2006
Study Completion
January 1, 2011
Last Updated
August 1, 2014
Record last verified: 2014-07