Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males With Hemophilia
A Multiclinic, Open Pilot Study to Investigate the Effect of Combination Antiretroviral Therapy Including Indinavir Sulfate on Coagulation Factors, on Platelet Aggregation, and on Factor VIII/IX Half-Life in HIV-1 Seropositive Patients With Hemophilia A or B
2 other identifiers
interventional
55
2 countries
8
Brief Summary
The purpose of this study is to see if indinavir plus two other anti-HIV drugs affect blood clotting in HIV-positive patients with hemophilia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4 hiv-infections
8 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 2, 1999
CompletedFirst Posted
Study publicly available on registry
August 31, 2001
CompletedJune 24, 2005
June 1, 1999
November 2, 1999
June 23, 2005
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- You may be eligible for this study if you:
- Are an HIV-positive male.
- Have been diagnosed with hemophilia.
- Have been taking clotting factors for hemophilia for at least 6 months.
- Have been taking a combination of one protease inhibitor plus two other anti-HIV drugs for at least 6 months, or have never taken a protease inhibitor.
- Are at least 16 years old (consent of parent or guardian required if under 18).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (8)
USCF
San Francisco, California, 94143, United States
Georgetown U Med Ctr / Div of Hematology / Oncology
Washington D.C., District of Columbia, 20007, United States
Emory Univ
Atlanta, Georgia, 30322, United States
Riley Hosp for Children
Indianapolis, Indiana, 462025225, United States
Tulane Univ School of Medicine / Hematology / Oncology
New Orleans, Louisiana, 70112, United States
Univ of North Carolina School of Medicine / Div Hemat / Onco
Chapel Hill, North Carolina, 275997035, United States
Milton Hershey Med Ctr
Hershey, Pennsylvania, 170330850, United States
Montreal Gen Hosp
Montreal, Quebec, Canada