Success Metrics

Clinical Success Rate
92.4%

Based on 171 completed trials

Completion Rate
92%(171/185)
Active Trials
6(3%)
Results Posted
16%(28 trials)
Terminated
14(6%)

Phase Distribution

Ph phase_1
27
12%
Ph early_phase_1
1
0%
Ph phase_3
53
24%
Ph not_applicable
33
15%
Ph phase_2
56
26%
Ph phase_4
44
20%

Phase Distribution

28

Early Stage

56

Mid Stage

97

Late Stage

Phase Distribution214 total trials
Early Phase 1First-in-human
1(0.5%)
Phase 1Safety & dosage
27(12.6%)
Phase 2Efficacy & side effects
56(26.2%)
Phase 3Large-scale testing
53(24.8%)
Phase 4Post-market surveillance
44(20.6%)
N/ANon-phased studies
33(15.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

89.1%

171 of 192 finished

Non-Completion Rate

10.9%

21 ended early

Currently Active

6

trials recruiting

Total Trials

219

all time

Status Distribution
Active(7)
Completed(171)
Terminated(21)
Other(20)

Detailed Status

Completed171
unknown18
Terminated14
Withdrawn7
Active, not recruiting3
Recruiting3

Development Timeline

Analytics

Development Status

Total Trials
219
Active
6
Success Rate
92.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.5%)
Phase 127 (12.6%)
Phase 256 (26.2%)
Phase 353 (24.8%)
Phase 444 (20.6%)
N/A33 (15.4%)

Trials by Status

unknown188%
active_not_recruiting31%
completed17178%
not_yet_recruiting10%
recruiting31%
suspended21%
terminated146%
withdrawn73%

Recent Activity

Clinical Trials (219)

Showing 20 of 219 trialsScroll for more
NCT02369406Phase 2

Early Infant HIV Treatment in Botswana

Active Not Recruiting
NCT06494579Phase 1

Lamivudine for Solid Tumors

Active Not Recruiting
NCT04696575Phase 2

Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer

Recruiting
NCT05979311Phase 3

A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy

Active Not Recruiting
NCT07058974Phase 1

A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation

Recruiting
NCT02470650Phase 4

Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV Naive

Withdrawn
NCT03311945Phase 3

Simplification Study of HIV-1 Infected Patients With Virological Suppression Under the Combination of Lamivudine (150 mg BID) Plus Raltegravir (400 mg BID) Switching to Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) : Roll-over Study of the RALAM

Completed
NCT02652793Not Applicable

Simplification From Tenofovir Plus Lamivudine or Emtricitabine Plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir Plus Lamivudine in Virologically-Suppressed-HIVInfected Adults With Osteopenia

Completed
NCT06428045Phase 1

STARLITE for Unresectable High-Grade Gliomas

Recruiting
NCT03333083Phase 3

Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug Interactions With Their Current Regimen

Terminated
NCT04862975

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana

Completed
NCT06503796Phase 4

Antiviral Therapy in Infants With HBV Infection

Not Yet Recruiting
NCT00799864Phase 2

A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 Years

Completed
NCT03144804Phase 2

A Phase 2 Study of Lamivudine in Patients With p53 Mutant Metastatic Colorectal Cancer

Completed
NCT01620944Phase 3

Open-Label Study Comparing Efficacy and Safety of ATV/RTV+3TC With ATV/RTV+TDF/FTC in HIV-Infected, Treatment Naïve Subjects, Followed by Treatment With ATV/RTV+3TC

Terminated
NCT04022967Phase 3

ANRS 12372 MODERATO Study

Unknown
NCT00350272Phase 2

Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in Human Immunodeficiency Virus (HIV)-1 Infected, Treatment-naive Participants

Completed
NCT00312039Phase 1

Study of Once Daily Elvucitabine Versus Lamivudine in Participants With a Documented M184V Mutation

Completed
NCT00380159Phase 2

Open-Label, 48-Week Extension Study of Elvucitabine in Combination With Background Antiretroviral Therapy (ART) for Participants Who Have Completed Study ACH443-014A

Completed
NCT03272347Phase 2

Islatravir (MK-8591) With Doravirine and Lamivudine in Participants Infected With Human Immunodeficiency Virus Type 1 (MK-8591-011)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
219