Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects

NCT00001919 | Completed

• 2 other identifiers: 99015199-M-0151
• Study Type: observational
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

St. John's Wort is a popular dietary supplement that many people take to elevate mood or relieve stress. This study will test in normal volunteers whether this preparation may alter mood and if so, by what means. Animal studies suggest that St. John's Wort may work similarly to some antidepressants that affect levels of the chemical serotonin in the brain. Participants in this study must also be enrolled in NIMH protocol #98-M-0094 (SPECT Imaging of Dopamine and Serotonin Transporters in Neuropsychiatric Patients and Normal Volunteers) and protocol #91-M-014 (MRI Imaging of Neuropsychiatric Patients and Controls). Separate consent forms are required for each study. Candidates will undergo medical and psychiatric evaluations that may include blood and urine tests, electroencephalogram and electrocardiogram. Normal volunteers will have a mood assessment at the beginning of the study. They will then be randomly assigned to take either placebo (a pill with no active ingredient) or St. John's Wort 3 times a day for 2 weeks, and will be told what they are taking. After an 11-week hiatus, they will again start treatment on the same schedule, but will not be told which preparation they are receiving. Each evening during the 2-week treatment periods, subjects will complete a brief self-rating mood assessment questionnaire. At the end of each treatment period, they will undergo SPECT brain imaging (a type of CT scan) to determine dopamine and serotonin distribution and density in the brain. For this procedure, study subjects take three drops of potassium iodide solution within 24 hours before the scan and two drops nightly for 3 days following the procedure. About 10 ml (less than two teaspoons) of blood are drawn before a radioactive tracer is injected. SPECT imaging is done the next day. After about 1 hour of imaging, subjects are given either a placebo or St. John's Wort, and then imaging continues for another 2 hours. During the procedure, up to five blood samples of 6 ml each may be drawn. At some point during the study, a MRI scan of the brain will be done.

Conditions

Healthy; Mood Disorder

Keywords

Mechanism of Action; BCIT-SPECT; St. John's Wort; Hypericum Perforatum; Depression; Serotonin; Dopamine Transporter; SPECT; Brain Disorders

Interventions

Hypericum (LI-160) DRUG

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Free of concomitant medications and must be willing to take hypericum for a period of two weeks and a placebo for two weeks. No subjects with a relevant Axis I or Axis II disorder. No subjects with concomitant medical or neurological disorders which require ongoing medication, or which may affect the central nervous system; or taking medication with which St. John's wort may interact. Must not be pregnant. Must not be breastfeeding. No subjects with a prior reaction to iodine, iodine compounds, or shellfish. No subjects with a history of thyroid disease or dysfunction. No subjects with a history of recent substance abuse. No subjects with metal objects in their bodies. No subjects with a prior adverse reaction to hypericum extracts. No women who taking birth control pills.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (2)

• Bennett DA Jr, Phun L, Polk JF, Voglino SA, Zlotnik V, Raffa RB. Neuropharmacology of St. John's Wort (Hypericum). Ann Pharmacother. 1998 Nov;32(11):1201-8. doi: 10.1345/aph.18026.

  PMID: 9825087 BACKGROUND

• Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Muller WE. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci. 1998;63(6):499-510. doi: 10.1016/s0024-3205(98)00299-9.

  PMID: 9718074 BACKGROUND

MeSH Terms

Conditions

Mood Disorders; Depression; Brain Diseases

Interventions

Hypericum extract LI 160

Condition Hierarchy (Ancestors)

Mental Disorders; Behavioral Symptoms; Behavior; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: September 1, 1999
• Study Completion: June 1, 2002
• Last Updated: March 4, 2008

Record last verified: 2002-06

Locations

US (1)