Adolescence, Puberty, and Emotion Regulation

NCT00016731 | Completed

• 2 other identifiers: 01015201-M-0152
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to use brain imaging technology to compare how the brains of adolescents and adults are activated during tasks that involve emotional responses. Evidence suggests that adolescents and adults experience activation in similar brain regions when they engage in tasks that involve the processing of emotional stimuli. However, the degree of task-associated activation may differ between adolescents and adults. This study will use functional magnetic resonance imaging (fMRI) to compare brain activation patterns in adolescents and adults. This study will also be used to develop emotion-evoking fMRI tasks to determine whether there are puberty and age-linked components of brain development.

Conditions

Mood Disorder; Neurobehavioral Manifestation; Healthy

Keywords

Depression; Anxiety; CAH; Adults; FMPP; Emotion; Cushing's Syndrome; Adolescence; Magnetic Resonance Imaging; fMRI; Healthy Volunteer; HV; MRI

Eligibility Criteria

• Age: 8 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age: 9-25 (adolescents/young adults); 25-35 (adults).
• Consent: can give consent/assent. Parents will provide consent for all minors.
• IQ: all subjects will have an IQ greater than 70; assessment relies on WASI.
• Psychopathology: all subjects will be free of any current psychiatric disorder as well as lifetime history of psychosis, pervasive developmental disorder, major affective disorder, panic disorder, obsessive compulsive disorder, conduct disorder, ADHD, and anorexia. Assessment relies on comprehensive psychiatric interview.
• Age: 9-25 (adolescents/young adults); 25-35 (adults).
• Consent: can give consent/assent. Parents will provide consent for all minors.
• IQ: all subjects will have an IQ greater than 70. Assessment relies on WASI

You may not qualify if:

• Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye)
• Pregnancy

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lepine JP, Newman SC, Oakley-Browne MA, Rubio-Stipec M, Wells JE, Wickramaratne PJ, Wittchen HU, Yeh EK. The cross-national epidemiology of panic disorder. Arch Gen Psychiatry. 1997 Apr;54(4):305-9. doi: 10.1001/archpsyc.1997.01830160021003.

  PMID: 9107146 BACKGROUND

• Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994 Jan;51(1):8-19. doi: 10.1001/archpsyc.1994.03950010008002.

  PMID: 8279933 BACKGROUND

• Pine DS, Cohen P, Gurley D, Brook J, Ma Y. The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry. 1998 Jan;55(1):56-64. doi: 10.1001/archpsyc.55.1.56.

  PMID: 9435761 BACKGROUND

MeSH Terms

Conditions

Mood Disorders; Neurobehavioral Manifestations; Depression; Anxiety Disorders; Cushing Syndrome

Condition Hierarchy (Ancestors)

Mental Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavioral Symptoms; Behavior; Adrenocortical Hyperfunction; Adrenal Gland Diseases; Endocrine System Diseases

Study Officials

• Monique Ernst, M.D.

  National Institute of Mental Health (NIMH)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 31, 2001
• First Posted: June 1, 2001
• Study Start: May 29, 2001
• Study Completion: October 18, 2017
• Last Updated: December 17, 2019

Record last verified: 2017-10-18

Locations

US (1)