The Role of Emotion in the Development of Psychopathology

NCT00001654 | Completed

• 2 other identifiers: 97011697-M-0116
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

The dysregulated experience and expression of emotion is implicated in psychiatric disorders associated both with externalizing problems (aggressive, antisocial behaviors) and internalizing problems (anxiety, depression). Adolescence is a critical juncture in the development of these disorders because of the increased incidence and differentiation of clinical problems during this time period. This is a biobehavioral, longitudinal investigation of the role of emotion in the development of psychopathology in adolescence. The focus is on socialization experiences and biological processes that contribute to emotion dysregulation and disorder in male and female youths between 11 and 16 years of age. Groups studied include (1) comorbid externalizers and internalizers, (2) externalizers only, (3) internalizers only, and (4) asymptomatic youth. The adolescents are assessed again two years later, with instruments and paradigms similar to those used at Time 1. One theme pertains to the integration and disconnection of emotions across systems (e.g., physiological and self-report of experience), and how different patterns of emotion relate to psychopathology. A second theme pertains to development changes in how disorders are manifested (e.g., increased differentiation along gender specific pathways). The anticipated number of patient days per year is 240 for adolescents and mothers, and 120 days for fathers.

Conditions

Mood Disorder

Keywords

Adolescence; Comorbid Disorders; Physiology; Socialization; Gender; Conduct Problems; Anxiety; Sadness; Emotion; Psychophysiology

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects and their families will be recruited from the community.
• Individuals meeting entry criteria will be offered entry into the study, and others will be notified.

You may not qualify if:

• A debilitating physical impairment (e.g., seizure disorder, cerebral palsy, head trauma).
• Significant intellectual impairment (i.e., IQ less than 70).
• History of psychosis.
• Any condition that would impair a participant's ability to respond to the study's paradigms will be excluded from this study at the time of screening.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Akil H, Haskett RF, Young EA, Grunhaus L, Kotun J, Weinberg V, Greden J, Watson SJ. Multiple HPA profiles in endogenous depression: effect of age and sex on cortisol and beta-endorphin. Biol Psychiatry. 1993 Jan 15;33(2):73-85. doi: 10.1016/0006-3223(93)90305-w.

  PMID: 8382535 BACKGROUND

• Angold A, Costello EJ. Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues. Am J Psychiatry. 1993 Dec;150(12):1779-91. doi: 10.1176/ajp.150.12.1779.

  PMID: 8238631 BACKGROUND

• Anderson JC, Williams S, McGee R, Silva PA. DSM-III disorders in preadolescent children. Prevalence in a large sample from the general population. Arch Gen Psychiatry. 1987 Jan;44(1):69-76. doi: 10.1001/archpsyc.1987.01800130081010.

  PMID: 2432848 BACKGROUND

MeSH Terms

Conditions

Mood Disorders; Coitus; Anxiety Disorders

Condition Hierarchy (Ancestors)

Mental Disorders; Sexual Behavior; Behavior

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: May 1, 1997
• Study Completion: May 1, 2003
• Last Updated: March 4, 2008

Record last verified: 2003-05

Locations

US (1)