NCT00001753

Brief Summary

This study will examine the role of temperature in changing energy metabolism in human muscle. In order to do this, researchers will use magnetic resonance imaging (MRI) to provide information about how parts of muscle operate during exercise. Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). In this study, MRI will be used to measure the temperature and energy level of specific muscles during rest and exercise. In addition, the muscles being tested will be heated and cooled to see if temperature directly affects levels of energy in muscle.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
17

participants targeted

Target at below P25 for phase_1 healthy

Timeline
Completed

Started Sep 1998

Longer than P75 for phase_1 healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1998

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
12 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2000

Completed
2.1 years until next milestone

First Posted

Study publicly available on registry

December 10, 2002

Completed
Last Updated

March 4, 2008

Status Verified

August 1, 1999

First QC Date

November 3, 1999

Last Update Submit

March 3, 2008

Conditions

Healthy

Keywords

ExerciseMRIMRSNormal VolunteerTibialix Anterior

Interventions

Magnetic resonance imagingPROCEDURE

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Ages 18 to 50. Male and female subjects. Capable of giving informed consent. Healthy normal volunteers. No cardiac pacemaker of implantable defibrillator. No aneurysm clip. No neural stimulator (e.g. TENS-unit). No ear implant of any type. No metal in the eye (e.g. from machining). No implanted device (e.g. insulin pump, drug infusion device). No metallic foreign body, shrapnel, or bullet.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

National Heart, Lung and Blood Institute (NHLBI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

  • Fowler MD, Ryschon TW, Wysong RE, Combs CA, Balaban RS. Normalized metabolic stress for 31P-MR spectroscopy studies of human skeletal muscle: MVC vs. muscle volume. J Appl Physiol (1985). 1997 Sep;83(3):875-83. doi: 10.1152/jappl.1997.83.3.875.

    PMID: 9292476BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Spectrum AnalysisChemistry Techniques, AnalyticalInvestigative Techniques

Study Design

Study Type
interventional
Phase
phase 1
Purpose
TREATMENT
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

December 10, 2002

Study Start

September 1, 1998

Study Completion

November 1, 2000

Last Updated

March 4, 2008

Record last verified: 1999-08

Locations

US(1)