Oxaliplatin in Cancer Patients With Impaired Kidney Function

NCT00001835 | Completed Phase 1

• 2 other identifiers: 99017199-C-0171
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Oxaliplatin is an experimental anti-cancer drug that can shrink tumors such as colon cancer. However, because this drug can damage the kidneys, it is necessary to determine what doses of the drug can safely be given to patients with poor kidney function. Patients with advanced cancer, poorly functioning kidneys, and no good standard treatment options are eligible for this study. Candidates will be screened with imaging tests, such as CT and MRI scans, to determine the size and location of the cancer and with blood and urine tests to evaluate kidney and liver function. Study participants will receive oxaliplatin intravenously (through a vein) every 3 weeks for as long as the cancer is under control and there are no serious side effects from the drug. If significant side effects develop, the dosage will be reduced, or the drug will be stopped. Blood tests to measure blood cell counts will be done at least once a week, and CT scans, chest X-rays, and MRIs will be done about once every 6 weeks to assess the tumor's response to the treatment. Additional blood tests will be done at the beginning of the first two treatment cycles to measure the amount of oxaliplatin in the blood, and urine will be collected during the first 24 hours of drug treatment to determine how much drug is eliminated by the body in urine.

Conditions

Kidney Disease; Neoplasm; Neoplasm Metastasis

Keywords

Renal Dysfunction; Pharmacokinetics; Platinum Analogues; Renal Cancer; Kidney Cancer

Interventions

Oxaliplatin DRUG

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Patients must have histologically confirmed malignancy which is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective. Patients with prior chemotherapy, radiation therapy, hormonal therapy and immunotherapy are allowed with the exception that patients cannot have had prior treatment with oxaliplatin. Patients greater than or equal to 18 years of age. Patients must have an ECOG performance status less than or equal to 2 (Karnofsky greater than or equal to 60 percent) and a life expectancy of at least 3 months. Patients must have adequate organ and marrow function which includes: Leukocytes must be greater than or equal to 3,000/microliter. Absolute neutrophil count must be greater than or equal to 1,500/microliter. Platelet count must be greater than or equal to 100,000/microliter. Total bilirubin within normal institutional limits. AST (SGOT)/ALT(SGPT) less than or equal to 1.5 times the upper limit of normal. Patients with no evidence of clinically significant neuropathy. Women of child-bearing potential and men must agree to use adequate contraception. Patients must have the ability to understand and the willingness to sign a written informed consent document. Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study, or within 6 weeks of prior platinum therapy will be excluded. Patients undergoing therapy with other investigational agents will be excluded. Patients with known brain metastaseswill be excluded. Patients with a history of an allergy to platinum compounds will be excluded. Patients with uncontrolled intercurrent illness including but not limited to ongoing or active infection, symptomatic congestive heart failure, or unstable angina pectoris, or cardiac arrhythmia will be excluded. Women must not be pregnant or nursing. Patients must not be HIV-positive or receiving anti-retroviral therapy (HAART). Patients actively receiving renal dialysis treatments while on the study will be excluded.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

National Cancer Institute (NCI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Kraker AJ, Moore CW. Accumulation of cis-diamminedichloroplatinum(II) and platinum analogues by platinum-resistant murine leukemia cells in vitro. Cancer Res. 1988 Jan 1;48(1):9-13.

  PMID: 3335002 BACKGROUND

• Pendyala L, Creaven PJ. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res. 1993 Dec 15;53(24):5970-6.

  PMID: 8261411 BACKGROUND

• Rixe O, Ortuzar W, Alvarez M, Parker R, Reed E, Paull K, Fojo T. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel. Biochem Pharmacol. 1996 Dec 24;52(12):1855-65. doi: 10.1016/s0006-2952(97)81490-6.

  PMID: 8951344 BACKGROUND

MeSH Terms

Conditions

Kidney Diseases; Neoplasms; Neoplasm Metastasis; Renal Insufficiency; Kidney Neoplasms

Interventions

Oxaliplatin

Condition Hierarchy (Ancestors)

Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site

Intervention Hierarchy (Ancestors)

Coordination Complexes; Organic Chemicals

Study Design

• Study Type: interventional
• Phase: phase 1
• Purpose: TREATMENT
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: September 1, 1999
• Study Completion: December 1, 2001
• Last Updated: March 4, 2008

Record last verified: 2001-12

Locations

US (1)