Structure of the Herpes Simplex Virus Receptor

NCT00001648 | Completed

• 2 other identifiers: 97016697-I-0166
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the structure of the receptor molecule for the herpes simplex virus (HSV) and determine if the receptor's structure is related to susceptibility to infection with the virus. There are two types of herpes virus-HSV-1 and HSV-2. HSV-1 commonly causes cold sores, and HSV-2 usually causes genital herpes. The herpes virus enters (infects) cells through protein molecules on the cell's surface. This study will explore possible differences between the structure of the HSV receptor molecule in different people to understand better how infection occurs. The study will also look at proteins on white blood cells (Fc receptors, cytokines and mannose binding protein) that may influence the risk of infection with HSV. Information from this study may lead to new treatments to prevent HSV infection. People 18 years of age and older who are infected with HSV and people who are not infected with the virus may be eligible for this study. Participants will have blood drawn to confirm whether or not they have been infected with the virus. The blood sample will also be used to study the genes for the HSV receptor, Fc receptors, cytokines, mannose binding protein and related proteins on the white blood cells. No more than 40 milliliters (8 teaspoons) of blood will be drawn. Participants who are found to have antibodies to HSV-2 will be offered counseling and advice on practicing safe sex techniques to help prevent sexually transmitted diseases, including HSV-2 infection.

Conditions

Encephalitis; Herpes Simplex; Keratitis; Mouth Disease; Skin Disease

Keywords

HVEM Gene; HSV; Herpes Simplex Virus

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• HSV-2 Seronegative Patients:
• Individuals known or likely to be seronegative for HSV-2 will be recruited.
• All racial, gender, and ethnic groups will be considered.
• Adult volunteers at least 18 years of age.
• Volunteers who were seronegative for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot.
• Volunteers are willing to allow investigators to store their blood.
• HSV-2 seropositive patients (with or without symptoms):
• All racial and ethnic groups will be considered.
• Volunteers who were seropositive for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot.
• Volunteers are willing to allow investigators to store their blood.
• Normal Controls:
• To determine the frequency of a genetic polymorphism in a population that has not had prior screening for HSV, blood may be obtained from normal control blood donors.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Montgomery RI, Warner MS, Lum BJ, Spear PG. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell. 1996 Nov 1;87(3):427-36. doi: 10.1016/s0092-8674(00)81363-x.

  PMID: 8898196 BACKGROUND

• Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. J Biol Chem. 1997 May 30;272(22):14029-32. doi: 10.1074/jbc.272.22.14029.

  PMID: 9162022 BACKGROUND

• Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996 May 10;272(5263):872-7. doi: 10.1126/science.272.5263.872.

  PMID: 8629022 BACKGROUND

MeSH Terms

Conditions

Encephalitis; Herpes Simplex; Keratitis; Mouth Diseases; Skin Diseases

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neuroinflammatory Diseases; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Skin Diseases, Viral; Skin Diseases, Infectious; Skin and Connective Tissue Diseases; Corneal Diseases; Eye Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: August 20, 1997
• Study Completion: April 13, 2010
• Last Updated: July 2, 2017

Record last verified: 2010-04-13

Locations

US (1)