Non-Invasive Electrical Stimulation of the Human Brain

NCT00001216 | Completed

• 2 other identifiers: 86002086-N-0020
• Study Type: observational
• Target: 175
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders. Transcranial electrical stimulation is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function. Electrical stimulation involves placing electrodes on the scalp or skin and passing an electrical current between them. When this is done, an electrical field is created that activates areas of the brain that control muscles. Muscle activity as a result of the stimulation can be recorded and analyzed.

Conditions

Cerebrovascular Disorders; Healthy; Nervous System Diseases; Spinal Cord Injuries

Keywords

Amputations; Brainstem Stimulation; Cerebellar Stimulation; Cortical Motor Physiology; Electrical Stimulation; Motor Cortex; Plasticity; Spinal Cord Injury; Stroke

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Males and females, ages 18 and over. Diverse racial groups. Amputees and others with whom we will have no patient-care relationship may also be considered to be volunteers. Patients will be recruited from those referred to the Human Motor Control Section, NINDS who have neurological syndromes that are of interest. On rare occasions we may attempt to study children as young as 10 years with TES. Individuals without indwelling cardiac lines and pacemakers. Patients recruited for study would come from those referred to the EMG laboratory and to the Human Motor Control Clinic who would have distinct neurologic syndromes from well defined peripheral and central nervous system lesions including hemiplegia from stroke, trauma, tumor or focal demyelination (most commonly patients would have hemiplegia from stroke), peripheral nerve lesions, amputations, spinal cord injury. Normal volunteers, including NIH employees, would be healthy adults without history of physical examination evidence of neurologic disease and individuals with different types of amputations involving upper and lower extremities. Volunteers may also be participants in the electrophysiological protocol (84-N-0196). No history of epilepsy.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Cohen LG, Meer J, Tarkka I, Bierner S, Leiderman DB, Dubinsky RM, Sanes JN, Jabbari B, Branscum B, Hallett M. Congenital mirror movements. Abnormal organization of motor pathways in two patients. Brain. 1991 Feb;114 ( Pt 1B):381-403. doi: 10.1093/brain/114.1.381.

  PMID: 2004248 BACKGROUND

• Brasil-Neto JP, Pascual-Leone A, Valls-Sole J, Cammarota A, Cohen LG, Hallett M. Postexercise depression of motor evoked potentials: a measure of central nervous system fatigue. Exp Brain Res. 1993;93(1):181-4. doi: 10.1007/BF00227794.

  PMID: 8467889 BACKGROUND

• Brasil-Neto JP, Cohen LG, Pascual-Leone A, Jabir FK, Wall RT, Hallett M. Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm: a study with transcranial magnetic stimulation. Neurology. 1992 Jul;42(7):1302-6. doi: 10.1212/wnl.42.7.1302.

  PMID: 1620338 BACKGROUND

MeSH Terms

Conditions

Cerebrovascular Disorders; Nervous System Diseases; Spinal Cord Injuries; Stroke

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Spinal Cord Diseases; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: December 10, 2002
• Study Start: February 1, 1986
• Study Completion: February 1, 2001
• Last Updated: March 4, 2008

Record last verified: 1999-12

Locations

US (1)