Study of the Psychological Development of Children of Parents With and Without Affective Disorders

NCT00001170 | Completed

• 2 other identifiers: 79012379-M-0123
• Study Type: observational
• Target: 1,045
• Locations: 1 country
• Sites: 1

Brief Summary

This research study is the continuation of a study started more than 20 years ago. The study was designed to explore the effect that depressed parents have on their children and to better understand the factors that contribute to depression development and maintenance. The study will continue to investigate if children have certain characteristics in early and middle childhood that predict the later development of psychological disorders. In addition, the study will continue looking at the processes responsible for the development of children of parents with and without affective (mood) disorders.

Conditions

Bipolar Disorder; Involutional Depression; Mood Disorder

Keywords

Parental Psychopathology; Child Rearing; Depression; Bipolar Affective Disorders; Manic-Depression; Social-Emotional Development; Cognitive Development; Child Psychopathology; Affective Disorder; Children at Risk

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Patients will be drawn from an ongoing longitudinal study begun in 1979 of offspring of parents with affective illness (unipolar and bipolar) and children of normal control parents.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (5)

• Achenbach TM, Edelbrock CS. The Child Behavior Profile: II. Boys aged 12-16 and girls aged 6-11 and 12-16. J Consult Clin Psychol. 1979 Apr;47(2):223-33. doi: 10.1037//0022-006x.47.2.223. No abstract available.

  PMID: 469068 BACKGROUND

• Beardslee WR, Bemporad J, Keller MB, Klerman GL. Children of parents with major affective disorder: a review. Am J Psychiatry. 1983 Jul;140(7):825-32. doi: 10.1176/ajp.140.7.825.

  PMID: 6344660 BACKGROUND

• Billings AG, Moos RH. Comparisons of children of depressed and nondepressed parents: a social-environmental perspective. J Abnorm Child Psychol. 1983 Dec;11(4):463-85. doi: 10.1007/BF00917076.

  PMID: 6655148 BACKGROUND

• Labella MH, Ruiz SK, Harris SJ, Klimes-Dougan B. Emotion socialization in mothers with mood disorders: Affective modeling and recollected responses to childhood emotion. Dev Psychopathol. 2021 Oct;33(4):1156-1169. doi: 10.1017/S0954579420000395.

  PMID: 32672147 DERIVED

• Klimes-Dougan B, Long JD, Lee CY, Ronsaville DS, Gold PW, Martinez PE. Continuity and cascade in offspring of bipolar parents: a longitudinal study of externalizing, internalizing, and thought problems. Dev Psychopathol. 2010 Nov;22(4):849-66. doi: 10.1017/S0954579410000507.

  PMID: 20883586 DERIVED

MeSH Terms

Conditions

Bipolar Disorder; Depressive Disorder, Major; Mood Disorders; Depression

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mental Disorders; Depressive Disorder; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: October 1, 1979
• Study Completion: February 1, 2005
• Last Updated: March 4, 2008

Record last verified: 2005-02

Locations

US (1)