A Study of the Long-Term Outcomes of HIV-Positive Patients
A Prospective Study of Long-Term Clinical, Virologic, and Immunologic Outcomes in HIV-Infected Individuals
2 other identifiers
observational
3,669
1 country
91
Brief Summary
The purpose of this study is to collect information about life spans and HIV-related illnesses in multiple groups of HIV-positive patients with varying anti-HIV treatment experience, including no treatment at all. Anti-HIV treatment has been successful in slowing disease progression in many patients. However, there are still questions regarding the best way to use anti-HIV drugs. This study is designed to provide long-term monitoring of patients who have already received anti-HIV treatment as well as patients who are just beginning treatment or have decided not to receive treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 1999
Longer than P75 for all trials
91 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 1999
CompletedFirst Submitted
Initial submission to the registry
November 2, 1999
CompletedFirst Posted
Study publicly available on registry
August 31, 2001
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2006
CompletedApril 15, 2014
April 1, 2014
7.5 years
November 2, 1999
April 14, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Clinical disease progression or death
Throughout study
Secondary Outcomes (5)
Survival
Throughout study
Selected metabolic, hepatic, and cardiovascular conditions
Throughout study
Changes in viral load
Throughout study
Changes in CD4 count
Throughout study
Changes in HIV treatment methods
Throughout study
Study Arms (3)
A
Participants currently enrolled in or currently being followed in an ongoing qualifying study. Qualifying studies can be found in the protocol.
B
Participants previously enrolled in but not currently being followed in a qualifying study. Qualifying studies can be found in the protocol.
C
Antiretroviral-naive participants not enrolling in a qualifying study (i.e., patients starting treatment outside the first study or patients deferring treatment)
Eligibility Criteria
HIV infected individuals
You may qualify if:
- Patients may be eligible for this study if they:
- Are 13 years of age or older (consent of parent or guardian required if under the age of 18).
- Are HIV-positive.
- Have either: (1) no previous experience with anti-HIV treatment (defined as no previous protease inhibitor or nonnucleoside reverse transcriptase inhibitor use, 1 week or less of lamivudine use, and 4 weeks or less of cumulative nucleoside reverse transcriptase inhibitor use) or (2) current or previous enrollment in a qualifying CPCRA study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (91)
Dr. M. Estes Med. Practice CRS
Mill Valley, California, 94941-3013, United States
Dr. Robert Scott Med. Practice CRS
Oakland, California, 94609, United States
East Bay AIDS Ctr. CRS
Oakland, California, 94609, United States
Dr. Shawn Hassler Med. Practice CRS
San Francisco, California, 94102, United States
Positive Health Program Clinic (San Francisco Gen. Hosp.) CRS
San Francisco, California, 94110, United States
Dr. Virginia Cafaro Med. Practice CRS
San Francisco, California, 94114-1010, United States
Dr. William Owen Med. Practice CRS
San Francisco, California, 94114-1010, United States
Castro-Mission Health Ctr. CRS
San Francisco, California, 94114, United States
Dr. Martin Mass Med. Practice CRS
San Francisco, California, 94114, United States
St. Mary's Med. Ctr. of San Francisco CRS
San Francisco, California, 94117, United States
San Francisco VAMC, Infectious Diseases Clinic CRS
San Francisco, California, 94121, United States
UCSF PHP, Gen. Internal Medicine Practice CRS
San Francisco, California, 94143, United States
Beacon Clinic at Boulder CRS
Boulder, Colorado, 80501-4507, United States
Denver Infectious Diseases Consultants CRS
Denver, Colorado, 80204-4507, United States
Kaiser Permanente of Denver CRS
Denver, Colorado, 80204-4507, United States
Univ. of Colorado Health Science Ctr. CRS
Denver, Colorado, 80204-4507, United States
Denver Public Health CRS
Denver, Colorado, 80204, United States
Eastside Family Health Ctr. CRS
Denver, Colorado, 80205, United States
APEX Family Medicine CRS
Denver, Colorado, 80206, United States
South Denver Infectious Diseases Specialists, Accord Med. Ctr. CRS
Denver, Colorado, 80218, United States
Denver Public Health CRS - INSIGHT
Denver, Colorado, United States
Western Infectious Disease Consultants CRS
Wheat Ridge, Colorado, 80033, United States
Univ. of Connecticut Health Ctr. CRS
Farmington, Connecticut, 06030, United States
Yale Univ. School of Medicine, NE ProACT - New Haven CRS
New Haven, Connecticut, 06510, United States
Hosp. of St. Raphael CRS
New Haven, Connecticut, 06511, United States
Dotson & Hodge Med. Group, L.L.C. CRS
Washington D.C., District of Columbia, 20003, United States
Dr. Timothy A. Price Med. Practice CRS
Washington D.C., District of Columbia, 20036, United States
Washington DC VAMC, Washington Regional AIDS Program, Infectious Diseases CRS
Washington D.C., District of Columbia, 20422, United States
Klein & Slotten Medical Associates CRS
Chicago, Illinois, 60610, United States
Cook County Hosp. CORE Ctr. INSIGHT CRS
Chicago, Illinois, 60612, United States
Cook County Hosp. CORE Ctr.
Chicago, Illinois, 60612, United States
Univ. of Illinois Family Ctr. for Infectious Disease CRS
Chicago, Illinois, 60612, United States
Lakeshore Infectious Disease Associates CRS
Chicago, Illinois, 60657, United States
North Side Family Medicine CRS
Chicago, Illinois, 60657, United States
Northwestern Memorial Physicians Group CRS
Chicago, Illinois, 60657, United States
Triad Health Practice/Ill. Masonic Med. Ctr. CRS
Chicago, Illinois, 60657, United States
Earl K. Long Med. Ctr., LSU - Mid City EIC Clinic CRS
Baton Rouge, Louisiana, 70805, United States
James Osterberger, MD (Private Med. Practice) CRS
Baton Rouge, Louisiana, 70808-4390, United States
Med. Ctr. of Louisiana at New Orleans, HIV Outpatient Clinics CRS
New Orleans, Louisiana, 70112, United States
Tulane University Health Sciences Center, Louisiana Community AIDS Research Program(LaCARP) CRS
New Orleans, Louisiana, 70112, United States
Memorial Med. Ctr., Hematology-Oncology Services CRS
New Orleans, Louisiana, 70115, United States
New Orleans VAMC CRS
New Orleans, Louisiana, 70146, United States
CRI-Boston CRS
Boston, Massachusetts, 02115, United States
CRI-Springfield CRS
Springfield, Massachusetts, 01107, United States
Harper Hosp., Detroit CRS
Detroit, Michigan, 48201, United States
Wayne State Univ. INSIGHT CRS
Detroit, Michigan, 48201, United States
Henry Ford Hosp. CRS
Detroit, Michigan, 48202, United States
Detroit Community Health Connection, Inc. CRS
Detroit, Michigan, 48215, United States
Detroit Community Health Connection-2 CRS
Detroit, Michigan, 48215, United States
Cooper Univ. Hosp. CRS
Camden, New Jersey, 08103, United States
ID Care Inc. - Hillsborough CRS
Hillsborough, New Jersey, 08844, United States
Jersey Shore Univ. Med. Ctr. CRS
Neptune City, New Jersey, 07754, United States
Cathedral Healthcare System, St. Michael's Med. Ctr. CRS
Newark, New Jersey, 07103, United States
New Jersey Community Research Initiative, Jeffrey Bomser Clinic CRS
Newark, New Jersey, 07103, United States
St. Joseph's Hosp. & Med. Ctr. of New Jersey CRS
Paterson, New Jersey, 07503, United States
Raritan Bay Med. Ctr., Perth Amboy Division CRS
Perth Amboy, New Jersey, 08861, United States
ID Care - Randolph CRS
Randolph Township, New Jersey, 07869, United States
Infectious Disease Specialists of N.J., North Jersey Community Research Initiative CRS
Union, New Jersey, 07083, United States
The Early Intervention Program at Kennedy Hosp. CRS
Voorhees Township, New Jersey, 08043, United States
St. Vincent Hosp. & Med. Ctr. CRS
New York, New York, 10011, United States
HHC Methadone Maintenance, Treatment Program Unit 1 CRS
New York, New York, 10026, United States
Harlem Hospital Ctr./Columbia University CRS (Gordin CTU)
New York, New York, 10037-1802, United States
Bronx Prevention Center CRS
The Bronx, New York, 10452, United States
Bronx-Lebanon Hosp. Ctr. CRS
The Bronx, New York, 10457, United States
Jacobi Med. Ctr., Ambulatory Care Pavillion CRS
The Bronx, New York, 10461, United States
Jacobi Med. Ctr.
The Bronx, New York, 10461, United States
Montefiore Med. Ctr., AIDS Ctr. CRS
The Bronx, New York, 10467, United States
Multnomah County Health Dept., HIV Health Services Ctr. CRS
Portland, Oregon, 97204, United States
Legacy Clinic Good Samaritan CRS
Portland, Oregon, 97210, United States
The Research & Education Group-Portland CRS
Portland, Oregon, 97210, United States
Providence Portland Med. Ctr., Ambulatory Care and Education Ctr. CRS
Portland, Oregon, 97213, United States
Kaiser Immune Deficiency Clinic of Portland CRS
Portland, Oregon, 97227, United States
Legacy Clinic Emanuel CRS
Portland, Oregon, 97227, United States
Oregon Health & Sciences Univ. Internal Medicine (L-475) CRS
Portland, Oregon, 97239, United States
Salem Hosp. CRS
Salem, Oregon, 97301, United States
Kaiser Permanente Lancaster Clinic CRS
Salem, Oregon, 97305, United States
Philadelphia FIGHT - Dr. Jay Kostman CRS
Philadelphia, Pennsylvania, 19107, United States
Temple Univ. School of Medicine CRS
Philadelphia, Pennsylvania, 19140, United States
Legacy Community Health Services, Inc. CRS
Houston, Texas, 77006, United States
Baylor College of Medicine, Thomas St. Clinic CRS
Houston, Texas, 77030, United States
Houston AIDS Research Team CRS
Houston, Texas, 77030, United States
Michael E. DeBakey VAMC CRS
Houston, Texas, 77030, United States
Thomas Street Clinic CRS
Houston, Texas, 77030, United States
Hanover Med. Park (Mechanicsville, VA) CRS
Mechanicsville, Virginia, 23116, United States
Eastern Virginia Med. School, Ctr. for the Comprehensive Care of Immune Deficiency CRS
Norfolk, Virginia, 23507, United States
Petersburg Health Care Alliance CRS
Petersburg, Virginia, 23803, United States
CrossOver Health Ctr. CRS
Richmond, Virginia, 23224, United States
South Richmond Health Care Ctr. CRS
Richmond, Virginia, 23224, United States
Hunter Holmes McGuire VAMC CRS
Richmond, Virginia, 23249, United States
VCU Health Systems, Infectious Disease Clinic CRS
Richmond, Virginia, 23298, United States
Virginia Commonwealth Univ. Medical Ctr. CRS
Richmond, Virginia, 23298, United States
Related Publications (1)
Goetz MB, Leduc R, Kostman JR, Labriola AM, Lie Y, Weidler J, Coakley E, Bates M, Luskin-Hawk R; Long-Term Monitoring Study (CPCRA 060) and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). Relationship between HIV coreceptor tropism and disease progression in persons with untreated chronic HIV infection. J Acquir Immune Defic Syndr. 2009 Mar 1;50(3):259-66. doi: 10.1097/QAI.0b013e3181989a8b.
PMID: 19194318RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Jay Kostman
- STUDY CHAIR
Roberta Luskin-Hawk
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 2, 1999
First Posted
August 31, 2001
Study Start
March 1, 1999
Primary Completion
September 1, 2006
Study Completion
September 1, 2006
Last Updated
April 15, 2014
Record last verified: 2014-04