Exercise Training and Plasma Lipoproteins in Man

NCT00000519 | Completed Phase 3

• 2 other identifiers: 38R01HL024462
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine the effects in moderately obese subjects of weight loss by combined dieting and exercise training on risk factors for coronary artery disease including lipoprotein lipids, apoproteins and blood pressure.

Conditions

Cardiovascular Diseases; Coronary Disease; Heart Diseases; Hypertension; Myocardial Ischemia; Obesity

Interventions

diet, reducing BEHAVIORAL

exercise BEHAVIORAL

diet, fat-restricted BEHAVIORAL

Eligibility Criteria

• Age: 25 Years - 49 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

Men and women, ages 25-49. Subjects were overweight with blood pressure less than 160/95 mm Hg and total cholesterol less than 260 mm/dl.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Stanford University: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Related Publications (15)

• Camargo CA Jr, Vranizan KM, Dreon DM, Frey-Hewitt B, Wood PD. Alcohol, calorie intake, and adiposity in overweight men. J Am Coll Nutr. 1987 Jun;6(3):271-8. doi: 10.1080/07315724.1987.10720189.

  PMID: 3598024 BACKGROUND

• Stefanick ML, Frey-Hewitt B, Hoover CA, et al: The Effect of Active Weight Loss Achieved by Dieting Versus Exercise on Postheparin Hepatic and Lipoprotein Lipase Activity. In: Human Obesity. Wurtman RJ and Wurtman JJ, (Eds.), New York, The New York Academy of Sciences, 338-339, 1987.

  BACKGROUND

• Stefanick ML, Terry RB, Haskell WL, et al: Relationships of Changes in Postheparin Hepatic and Lipoprotein Lipase Activity to HDL-Cholesterol Changes Following Weight Loss Achieved by Dieting Versus Exercise. In: Cardiovascular Disease. Molecular and Cellular Mechanisms, Prevention and Treatment. Gallo LL, (Ed), New York, Plenum Press, 61-68, 1987.

  BACKGROUND

• Williams PT, Fortmann SP, Terry RB, Garay SC, Vranizan KM, Ellsworth N, Wood PD. Associations of dietary fat, regional adiposity, and blood pressure in men. JAMA. 1987 Jun 19;257(23):3251-6.

  PMID: 3586249 BACKGROUND

• Dreon DM, Frey-Hewitt B, Ellsworth N, Williams PT, Terry RB, Wood PD. Dietary fat:carbohydrate ratio and obesity in middle-aged men. Am J Clin Nutr. 1988 Jun;47(6):995-1000. doi: 10.1093/ajcn/47.6.995.

  PMID: 3376914 BACKGROUND

• Fortmann SP, Haskell WL, Wood PD. Effects of weight loss on clinic and ambulatory blood pressure in normotensive men. Am J Cardiol. 1988 Jul 1;62(1):89-93. doi: 10.1016/0002-9149(88)91370-7.

  PMID: 3381757 BACKGROUND

• Haskell WL, Stefanick ML, Superko HR: Influence of Exercise on Plasma Lipids and Lipoproteins. In: Exercise, Nutrition, and Energy Metabolism. Horton ES and Terjung RL, (Eds.), New York, Macmillan, 213-227, 1988.

  BACKGROUND

• Krauss RM, Williams PT, Lindgren FT, Wood PD. Coordinate changes in levels of human serum low and high density lipoprotein subclasses in healthy men. Arteriosclerosis. 1988 Mar-Apr;8(2):155-62. doi: 10.1161/01.atv.8.2.155.

  PMID: 3348757 BACKGROUND

• Kris-Etherton PM, Krummel D, Russell ME, Dreon D, Mackey S, Borchers J, Wood PD. The effect of diet on plasma lipids, lipoproteins, and coronary heart disease. J Am Diet Assoc. 1988 Nov;88(11):1373-400.

  PMID: 2846672 BACKGROUND

• Wood PD, Stefanick ML, Dreon DM, Frey-Hewitt B, Garay SC, Williams PT, Superko HR, Fortmann SP, Albers JJ, Vranizan KM, et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med. 1988 Nov 3;319(18):1173-9. doi: 10.1056/NEJM198811033191801.

  PMID: 3173455 BACKGROUND

• Terry RB, Wood PD, Haskell WL, Stefanick ML, Krauss RM. Regional adiposity patterns in relation to lipids, lipoprotein cholesterol, and lipoprotein subfraction mass in men. J Clin Endocrinol Metab. 1989 Jan;68(1):191-9. doi: 10.1210/jcem-68-1-191.

  PMID: 2909551 BACKGROUND

• Wood PD: Effects of Habitual Exercise on Lipoprotein Metabolism. In: Biological Effects of Physical Activity. Williams RS, Wallace AG, (Eds.), Champaign, IL, Human Kinetics Books, 45-54, 1989.

  BACKGROUND

• King AC, Frey-Hewitt B, Dreon DM, Wood PD. Diet vs exercise in weight maintenance. The effects of minimal intervention strategies on long-term outcomes in men. Arch Intern Med. 1989 Dec;149(12):2741-6. doi: 10.1001/archinte.149.12.2741.

  PMID: 2596943 BACKGROUND

• Frey-Hewitt B, Vranizan KM, Dreon DM, Wood PD. The effect of weight loss by dieting or exercise on resting metabolic rate in overweight men. Int J Obes. 1990 Apr;14(4):327-34.

  PMID: 2361810 BACKGROUND

• Wood PD, Stefanick ML, Williams PT, Haskell WL. The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. N Engl J Med. 1991 Aug 15;325(7):461-6. doi: 10.1056/NEJM199108153250703.

  PMID: 1852180 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Coronary Disease; Heart Diseases; Hypertension; Myocardial Ischemia; Obesity

Interventions

Diet, Reducing; Exercise; Diet, Fat-Restricted

Condition Hierarchy (Ancestors)

Vascular Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Purpose: PREVENTION
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 27, 1999
• First Posted: October 28, 1999
• Study Start: July 1, 1982
• Last Updated: June 26, 2013

Record last verified: 2013-06