Role of Instructions in Nitrous Oxide Effects and Choice - 10

NCT00000258 | Completed

• 3 other identifiers: NIDA-08391-10R01DA008391R01-08391-10
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.

Conditions

Opioid-Related Disorders; Substance-Related Disorders

Keywords

nitrous oxide; instruction; subjective effects; reinforcer; healthy volunteer

Outcome Measures

Primary Outcomes (1)

• Choice of nitrous oxide vs placebo

  Subjects inhaled placebo and varying per centages of nitrous oxide in sampling pair, then chose for third inhalation. One group was told which of the gases they were inhaling during sampling and one group as well as the technician administering the inhalant was blinded. Psychomotor tests were done at each dose.

  After 30 min inhalation of each

Study Arms (2)

Informed group

ACTIVE COMPARATOR

Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.

Drug: Nitrous oxide 10% & placebo; Drug: Nitrous oxide 20% & placebo; Drug: Nitrous oxide 30% & placebo; Drug: Nitrous oxide 40% and placebo

Non-informed Group

ACTIVE COMPARATOR

Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.

Drug: Nitrous oxide 10% & placebo; Drug: Nitrous oxide 20% & placebo; Drug: Nitrous oxide 30% & placebo; Drug: Nitrous oxide 40% and placebo

Interventions

Nitrous oxide 10% & placebo DRUG

Informed group; Non-informed Group

Nitrous oxide 20% & placebo DRUG

Informed group; Non-informed Group

Nitrous oxide 30% & placebo DRUG

Informed group; Non-informed Group

Nitrous oxide 40% and placebo DRUG

Informed group; Non-informed Group

Eligibility Criteria

• Age: 21 Years - 32 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Please contact site for information.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of Chicago: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Location

Related Publications (1)

• Zacny JP, Cho AM, Toledano AY, Galinkin J, Coalson DW, Klock PA, Klafta JM, Young CJ. Effects of information on the reinforcing, subjective, and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Nov 25;48(2):85-95. doi: 10.1016/s0376-8716(97)00114-2.

  PMID: 9363407 BACKGROUND

MeSH Terms

Conditions

Opioid-Related Disorders; Substance-Related Disorders

Interventions

Nitrous Oxide

Condition Hierarchy (Ancestors)

Narcotic-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Nitrogen Oxides; Gases; Inorganic Chemicals; Nitrogen Compounds; Oxides; Oxygen Compounds

Study Officials

• James Zacny, Ph.D.

  University of Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 20, 1999
• First Posted: September 21, 1999
• Study Start: April 1, 1996
• Primary Completion: November 1, 1997
• Study Completion: November 1, 1997
• Last Updated: May 28, 2015

Record last verified: 2015-05

Locations

US (1)