Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8
3 other identifiers
interventional
11
1 country
1
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine reinforcing effects of brief exposures to nitrous oxide in healthy volunteers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 1995
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 1995
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 1996
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 1996
CompletedFirst Submitted
Initial submission to the registry
September 20, 1999
CompletedFirst Posted
Study publicly available on registry
September 21, 1999
CompletedMay 28, 2015
May 1, 2015
1.3 years
September 20, 1999
May 26, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Choice of nitrous oxide vs placebo
Subjects underwent 4 sessions consisting of 2 sample tests (inhaling placebo and inhaling varying doses of N2O), then choosing which inhalant they wanted for a choice test. The subject \& the technician administering the inhalant were blinded. During each intervention and each session, subjects underwent psychomotor testing.
After 1.5 min of inhalation each of nitrous oxide then placebo
Study Arms (4)
Placebo + 20% N2O
ACTIVE COMPARATOR0% N2O inhaled during psychomotor testing, 20% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Placebo + 40% N2O
ACTIVE COMPARATOR0% N2O inhaled during psychomotor testing, 40% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Placebo + 60% N2O
ACTIVE COMPARATOR0% N2O inhaled during psychomotor testing, 60% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Placebo + 80% N2O
ACTIVE COMPARATOR0% N2O inhaled during psychomotor testing, 80% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- University of Chicagolead
- National Institute on Drug Abuse (NIDA)collaborator
Study Sites (1)
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, 60637, United States
Related Publications (1)
Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Klock PA, Toledano AY, Jordan N, Apfelbaum JL. The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1996 Nov;42(3):197-200. doi: 10.1016/s0376-8716(96)01281-1.
PMID: 8912802BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James Zacny, Ph.D.
University of Chicago
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 20, 1999
First Posted
September 21, 1999
Study Start
August 1, 1995
Primary Completion
November 1, 1996
Study Completion
November 1, 1996
Last Updated
May 28, 2015
Record last verified: 2015-05